Raising the Higgs mass with Yukawa couplings for isotriplets in vector-like extensions of minimal supersymmetry

Extra vector-like matter with both electroweak-singlet masses and large Yukawa couplings can significantly raise the lightest Higgs boson mass in supersymmetry through radiative corrections. I consider models of this type that involve a large Yukawa coupling between weak isotriplet and isodoublet chiral supermultiplets. The particle content can be completed to provide perturbative gauge coupling unification, in several different ways. The impact on precision electroweak observables is shown to be acceptably small, even if the new particles are as light as the current experimental bounds of order 100 GeV. I study the corrections to the lightest Higgs boson mass, and discuss the general features of the collider signatures for the new fermions in these models.Comment: 30 page

Cluster Probes of Dark Energy Clustering

Cluster abundances are oddly insensitive to canonical early dark energy. Early dark energy with sound speed equal to the speed of light cannot be distinguished from a quintessence model with the equivalent expansion history for $z<2$ but negligible early dark energy density, despite the different early growth rate. However, cold early dark energy, with a sound speed much smaller than the speed of light, can give a detectable signature. Combining cluster abundances with cosmic microwave background power spectra can determine the early dark energy fraction to 0.3 % and distinguish a true sound speed of 0.1 from 1 at 99 % confidence. We project constraints on early dark energy from the Euclid cluster survey, as well as the Dark Energy Survey, using both current and projected Planck CMB data, and assess the impact of cluster mass systematics. We also quantify the importance of dark energy perturbations, and the role of sound speed during a crossing of $w=-1$

Three-loop corrections to the lightest Higgs scalar boson mass in supersymmetry

I evaluate the largest three-loop corrections to the mass of the lightest Higgs scalar boson in the Minimal Supersymmetric Standard Model in a mass-independent renormalization scheme, using effective field theory and renormalization group methods. The contributions found here are those that depend only on strong and Yukawa interactions and on the leading and next-to-leading logarithms of the ratio of a typical superpartner mass scale to the top quark mass. The approximation assumes that all superpartners and the other Higgs bosons can be treated as much heavier than the top quark, but does not assume their degeneracy. I also discuss the consistent addition of the three-loop corrections to a complete two-loop calculation.Comment: 9 page

The transition of ground-based space environmental effects testing to the space environment

The goal of the space flight program at the Center for Commercial Development of Space (CCDS)--Materials for Space Structures is to provide environmentally stable structural materials to support the continued humanization and commercialization of the space frontier. Information on environmental stability will be obtained through space exposure, evaluation, documentation, and subsequent return to the supplier of the candidate material for internal investigation. This program provides engineering and scientific service to space systems development firms and also exposes CCDS development candidate materials to space environments representative of in-flight conditions. The maintenance of a technological edge in space for NASA suggests the immediate search for space materials that maintain their structural integrity and remain environmentally stable. The materials being considered for long-lived space structures are complex, high strength/weight ratio composites. In order for these new candidate materials to qualify for use in space structures, they must undergo strenuous testing to determine their reliability and stability when subjected to the space environment. Ultraviolet radiation, atomic oxygen, debris/micrometeoroids, charged particles radiation, and thermal fatigue all influence the design of space structural materials. The investigation of these environmental interactions is the key purpose of this center. Some of the topics discussed with respect to the above information include: the Space Transportation System, mission planning, spaceborne experiments, and space flight payloads

The Arecibo Dual-Beam Survey: Arecibo and VLA Observations

The Arecibo Dual-Beam Survey is a "blind" 21 cm search for galaxies covering \~430 deg^2 of sky. We present the data from the detection survey as well as from the follow-up observations to confirm detections and improve positions and flux measurements. We find 265 galaxies, many of which are extremely low surface brightness. Some of these previously uncataloged galaxies lie within the zone of avoidance where they are obscured by the gas and dust in our Galaxy. 81 of these sources are not previously cataloged optically and there are 11 galaxies that have no associated optical counterpart or are only tentatively associated with faint wisps of nebulosity on the Digitized Sky Survey images. We discuss the properties of the survey and in particular we make direct determinations of the completeness and reliability of the sample. The behavior of the completeness and its dependencies is essential for determining the HI mass function. We leave the discussion of the mass function for a later paper, but do note that we find many low surface brightness galaxies and 7 sources with M_HI < 10^8 Msolar.Comment: 23 pages, 20 figures, accepted ApJS. For tables 2 and 3 only the first page has been included. ASCII tables are provided separatel

MicroRNA-330-5p as a putative modulator of neoadjuvant chemoradiotherapy sensitivity in oesophageal adenocarcinoma

Oesophageal adenocarcinoma (OAC) is the sixth most common cause of cancer deaths worldwide, and the 5-year survival rate for patients diagnosed with the disease is approximately 17%. The standard of care for locally advanced disease is neoadjuvant chemotherapy or, more commonly, combined neoadjuvant chemoradiation therapy (neo-CRT) prior to surgery. Unfortunately, ~60-70% of patients will fail to respond to neo-CRT. Therefore, the identification of biomarkers indicative of patient response to treatment has significant clinical implications in the stratification of patient treatment. Furthermore, understanding the molecular mechanisms underpinning tumour response and resistance to neo-CRT will contribute towards the identification of novel therapeutic targets for enhancing OAC sensitivity to CRT. MicroRNAs (miRNA/miR) function to regulate gene and protein expression and play a causal role in cancer development and progression. MiRNAs have also been identified as modulators of key cellular pathways associated with resistance to CRT. Here, to identify miRNAs associated with resistance to CRT, pre-treatment diagnostic biopsy specimens from patients with OAC were analysed using miRNA-profiling arrays. In pre-treatment biopsies miR-330-5p was the most downregulated miRNA in patients who subsequently failed to respond to neo-CRT. The role of miR-330 as a potential modulator of tumour response and sensitivity to CRT in OAC was further investigated in vitro. Through vector-based overexpression the E2F1/p-AKT survival pathway, as previously described, was confirmed as a target of miR-330 regulation. However, miR-330-mediated alterations to the E2F1/p-AKT pathway were insufficient to significantly alter cellular sensitivity to chemotherapy (cisplatin and 5-flurouracil). In contrast, silencing of miR-330-5p enhanced, albeit subtly, cellular resistance to clinically relevant doses of radiation. This study highlights the need for further investigation into the potential of miR-330-5p as a predictive biomarker of patient sensitivity to neo-CRT and as a novel therapeutic target for manipulating cellular sensitivity to neo-CRT in patients with OAC

Minimal Universal Two-qubit Quantum Circuits

We give quantum circuits that simulate an arbitrary two-qubit unitary operator up to global phase. For several quantum gate libraries we prove that gate counts are optimal in worst and average cases. Our lower and upper bounds compare favorably to previously published results. Temporary storage is not used because it tends to be expensive in physical implementations. For each gate library, best gate counts can be achieved by a single universal circuit. To compute gate parameters in universal circuits, we only use closed-form algebraic expressions, and in particular do not rely on matrix exponentials. Our algorithm has been coded in C++.Comment: 8 pages, 2 tables and 4 figures. v3 adds a discussion of asymetry between Rx, Ry and Rz gates and describes a subtle circuit design problem arising when Ry gates are not available. v2 sharpens one of the loose bounds in v1. Proof techniques in v2 are noticeably revamped: they now rely less on circuit identities and more on directly-computed invariants of two-qubit operators. This makes proofs more constructive and easier to interpret as algorithm