Tapas and the Hero(ine)’s Journey: The Inner Fire of Transformation

This thesis offers an expository examination of the intersection of yoga’s modern tapas (austerity) practice and the framework of storytelling, contrasting and comparing these two ideals, by exploring the evolution of the term tapas and uncovering how it is mirrored by the hero(ine)’s journey identified by Joseph Campbell and other scholars. For humanity to evolve into a higher state of self-awareness and create a world where peaceful co-existence is possible, individuals must embark on an inner journey. Through this journey, our inner world evolves, which in turn can lead to more enlightened behavior and contribute to a more harmonious global community. To address humanity’s broader issues, a possible construct to guide the individual journey is at the intersection between yoga’s modern tapas and the framework for storytelling, as I explore through developing a tapas experience framework, to offer a compelling transformational journey and path forward for the practitioner

Caffeine used as a Tracer of Wastewater Contamination in South Florida

In this study, a method was developed to analyze caffeine levels of water samples collected in Miami, Florida. The method was used to determine caffeine concentrations in reclaimed water samples and environmental water samples using on-line solid phase extraction (SPE) high pressure liquid chromatography (HPLC) high resolution mass spectrometry (HRMS). The rising use and disposal of pharmaceuticals and personal care products are becoming a concern as contaminants increasingly enter lakes, streams, and rivers without proper removal by traditional wastewater treatment processes. Caffeine may be used as a chemical tracer to indicate the presence of contamination in water samples and to distinguish between wastewater and water from environmental sources, such as lakes and rivers. In this investigation, caffeine concentration was quantified using SPE-HPLC-HRMS. In addition, dissolved organic matter in samples, which includes caffeine, was qualitatively characterized using fluorescence excitation emission matrices (EEM). After analysis, reclaimed water samples were found to have a caffeine concentration ranging from 76.2 to 1041.21 ng/L with an average of 590.23 ng/L, and samples from the Miami Beach area were found to have a concentration ranging from 10.3 to 2061.61 ng/L with an average of 355.40 ng/L. Additional environmental samples were found to have caffeine concentrations ranging from 6.18 to 190 ng/L. With an elevated concentration in reclaimed water, caffeine can be used to distinguish sources of water based on influences from wastewater. Fluorescent EEMs showed similar fluorescent profiles for reclaimed waters and environmental water samples differing only in intensity. For each sample, intensity was found to correlate with caffeine concentration, suggesting that fluorescent data can be complementary to mass spectral data. The purpose of this study is to understand the occurrence of caffeine at trace concentrations in reclaimed and environmental waters for the ultimate purpose of improving wastewater treatment facilities. Overall, results indicate that caffeine shows potential as an environmental tracer of wastewater contamination in this region

Bisphosphonate-induced periprosthetic fracture: a cause of painful total hip arthroplasty

Background. Cases have been reported in the literature of periprosthetic fractures associated with the use of bisphosphonates occurring in the long term following a Total Hip Replacement (THR). We report an interesting case of periprosthetic fracture secondary to bisphosphonate use only a few months after a THR. Case Report. A 72-year-old lady (on bisphosphonates for 10 years) underwent a THR for osteoarthritis. She was pain-free in the first four months postoperatively. Thereafter, she developed spontaneous onset of pain in the lateral aspect of her thigh and groin and found it difficult to weight-bear. X-rays and blood tests were unremarkable. An ultrasound and MRI scan showed no evidence of effusion/collection or periprosthetic fracture. A radionuclide bone scan showed an abnormal appearance of the right femoral shaft. A subsequent CT scan showed an oblique vertical split on the anterior surface of the upper right femoral shaft. This stress fracture was managed nonoperatively with protected weight bearing. She has progressed well with good clinical and radiological signs of fracture healing. Conclusion. This case is an important addition to our knowledge that bisphosphonate-induced periprosthetic stress fractures can be a cause of hip pain only a few months following a THR.</p

Communiqué No. 16: Escalating Pension Benefit Costs -- Another Threat to Nonprofit Survival?

Provides findings from a national survey of nonprofits that examines the benefits of nonprofit retirement programs, explores the financial stress the plans are under, and describes the coping strategies developed by organizations

Communiqué No. 15: Health Care and Nonprofits: The Hidden Dimension of America's Health Care Crisis

Providings findings from a national survey that examines how nonprofits and their employees are affected by rising health care costs

Pragmatic engagement in a low trust supply chain: Beef farmers’ perceptions of power, trust and agency

The academic discussion of power in supply chains has changed from a discussion of the use of coercive power to one which emphasizes the role of trust in embedding co-operation and disincentivizing opportunism. Whilst a number of empirical studies have suggested the former is alive and well, this paper argues that power relations may also be constituted by the self-perceptions of weaker actors as much as by the explicit actions of more powerful ones. This study explores the role of power through the perceptions of subjugated actors, which set the ‘rules of the game’. Our case centres on perceptions of Northern Irish beef farmers and their reflections on their ‘powerlessness’ in relation to the larger, more consolidated processors that they sell to. We find that the way farmers make sense of the power relations they encounter is influenced by the individuating character of the power relations exercised by the processors, which debilitates their ability to collaborate and resist collectively. What emerges is a story about the process of accommodation whereby farmers pragmatically resign themselves to play by ‘the rules of the game’ to remain ‘part of the game’

The Energetics of Southern Ocean Upwelling

The ocean’s meridional overturning circulation is closed by the upwelling of dense, carbon-rich waters to the surface of the Southern Ocean. It has been proposed that upwelling in this region is driven by strong westerly winds, implying that the intensification of Southern Ocean winds in recent decades may have enhanced the rate of upwelling, potentially affecting the global overturning circulation. However, there is no consensus on the sensitivity of upwelling to winds or on the nature of the connection between Southern Ocean processes and the global overturning circulation. In this study, the sensitivity of the overturning circulation to changes in Southern Ocean westerly wind stress is investigated using an eddy-permitting ocean–sea ice model. In addition to a suite of standard circulation metrics, an energy analysis is used to aid dynamical interpretation of the model response. Increased Southern Ocean wind stress enhances the upper cell of the overturning circulation through creation of available potential energy in the Southern Hemisphere, associated with stronger upwelling of deep water. Poleward shifts in the Southern Ocean westerlies lead to a complicated transient response, with the formation of bottom water induced by increased polynya activity in the Weddell Sea and a weakening of the upper overturning cell in the Northern Hemisphere. The energetic consequences of the upper overturning cell response indicate an interhemispheric connection to the input of available potential energy in the Northern Hemisphere

Gene Catchr—Gene Cloning And Tagging for Caenorhabditis elegans using yeast Homologous Recombination: a novel approach for the analysis of gene expression

Expression patterns of gene products provide important insights into gene function. Reporter constructs are frequently used to analyze gene expression in Caenorhabditis elegans, but the sequence context of a given gene is inevitably altered in such constructs. As a result, these transgenes may lack regulatory elements required for proper gene expression. We developed Gene Catchr, a novel method of generating reporter constructs that exploits yeast homologous recombination (YHR) to subclone and tag worm genes while preserving their local sequence context. YHR facilitates the cloning of large genomic regions, allowing the isolation of regulatory sequences in promoters, introns, untranslated regions and flanking DNA. The endogenous regulatory context of a given gene is thus preserved, producing expression patterns that are as accurate as possible. Gene Catchr is flexible: any tag can be inserted at any position without introducing extra sequence. Each step is simple and can be adapted to process multiple genes in parallel. We show that expression patterns derived from Gene Catchr transgenes are consistent with previous reports and also describe novel expression data. Mutant rescue assays demonstrate that Gene Catchr-generated transgenes are functional. Our results validate the use of Gene Catchr as a valuable tool to study spatiotemporal gene expression

Diabetes, intracranial stenosis and microemboli in asymptomatic carotid stenosis

Background: The risk of stroke in patients with asymptomatic carotid stenosis (ACS) is now so low that it is important to have methods to identify those patients most likely to benefit from intervention, or who may require special consideration in choice of medical therapy. We studied the prediction of stroke, death or transient ischemic attacks (stroke/death/TIA) in patients with ACS by intracranial arterial stenosis, and microemboli on transcranial Doppler (TCD), and the effect of diabetes mellitus on microemboli, intracranial stenosis and risk of events. Methods: Patients with ACS \u3e 60% by Doppler ultrasound were recruited from the Stroke Prevention Clinic of University Hospital, London, Canada. All 339 participants underwent TCD for detection of intracranial stenosis and detection of microemboli, and carotid ultrasound to measure extracranial stenosis and total carotid plaque area. Participants were followed for three years, to determine the risk of stroke/death/TIA. Results: Stroke/death/TIA occurred in 38% of patients with microemboli versus 10% without (p=0.0001), and in 18% of patients with intracranial stenosis, versus 10% without (p=0.042). Diabetics were significantly more likely to have intracranial stenosis (45% vs. 29%, p =0.014), microemboli (38% vs. 10%, p \u3c0.0001), and had significantly higher risk of stroke/death/TIA over three years (21% vs. 11% without; p=0.024). Survival free of stroke, TIA or death was significantly better without microemboli or intracranial stenosis (p\u3c0.0001). Conclusions: Diabetes, microemboli and intracranial stenosis predicted higher risk of stroke, death or TIA than did extracranial stenosis or total plaque area; diabetics may need more intensive therapy

Use of computed tomography imaging during long-term follow-up of nine feline tuberculosis cases

Case series summary: Feline tuberculosis is an increasingly recognised potential zoonosis of cats. Treatment is challenging and prognosis can vary greatly between cases. Pulmonary infection requires extended courses of antibiotics, but methodologies for sensitively monitoring response to treatment are currently lacking. In this case series, we retrospectively examined the serial computed tomography (CT) findings in nine cats that had been diagnosed with tuberculosis. Changes in pathology (where applicable to tuberculosis) were correlated with the clinical presentation of each of the cats, the treatment protocol, and previous and contemporary diagnostic investigations. This study found that changes in CT findings during the medium- to long-term management of feline tuberculosis were highly variable between cats. The majority of cats had reduced pathology at re-examination during anti-tuberculous therapy, but pathology only resolved in a minority of cases. In some cases recurrence of pathology detected by CT imaging preceded clinical deterioration, allowing for rapid therapeutic intervention. Relevance and novel information: When considered in combination with clinical findings, CT studies can aid in decision making regarding tapering of antibiotic protocols, or reintroduction of therapy in cases of recurrence or reinfection. This series also highlights that, in some cases, persistent abnormalities can be detected by CT, so complete resolution of CT pathology should not always be a goal in the management of feline tuberculosis