Alien Registration- Webb, Stella V. (Monroe, Waldo County)

https://digitalmaine.com/alien_docs/5191/thumbnail.jp

The framing and fashioning of therapeutic citizenship among people living with HIV taking Antiretroviral Therapy in Uganda

In this article, we examine how people living with HIV (PLWH) were able to reconceptualize or “reframe” their understanding of HIV and enhance their capacity to self-manage the condition. Two in-depth interviews were held with 38 PLWH (20 women, 18 men) selected from three government and nongovernment antiretroviral therapy (ART) delivery sites in Wakiso District, and the narratives analyzed. ART providers played an important role in shaping participants’ HIV self-management processes. Health workers helped PLWH realize that they could control their condition, provided useful concepts and language for emotional coping, and gave advice about practical self-management tasks, although this could not always be put into practice. ART providers in this setting were spaces for the development of a collective identity and a particular form of therapeutic citizenship that encouraged self-management, including adherence to ART. Positive framing institutions are important for many PLWH in resource-limited settings and the success of ART programs

Smallanthus sonchifolius (Yacon) leaves: an emerging source of compounds for diabetes management

Diabetes mellitus is a chronic metabolic disease that develops mainly due to insulin deficiency or resistance to insulin action. All forms of diabetes are characterized by chronic hyperglycemia, which has an important role in the pathogenesis of diabetic complications. Leaves of Smallanthus sonchifolius (Poepp.&Endl.) H. Robinson (yacon) have been used since ancient times to prepare medicinal herbal tea with beneficial health properties. This review aims to discuss some key aspects related to the potential use of S. sonchifolius leaves and their natural biomolecules for the prophylaxis and treatment of diabetes as well as the potential mechanisms of action.Fil: Honore, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Genta, Susana Beatriz de Fátima. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentin

Analysis of X-ray flares in GRBs

We present a detailed study of the spectral and temporal properties of the X-ray flares emission of several GRBs. We select a sample of GRBs which X-ray light curve exhibits large amplitude variations with several rebrightenings superposed on the underlying three-segment broken powerlaw that is often seen in Swift GRBs. We try to understand the origin of these fluctuations giving some diagnostic in order to discriminate between refreshed shocks and late internal shocks. For some bursts our time-resolved spectral analysis supports the interpretation of a long-lived central engine, with rebrightenings consistent with energy injection in refreshed shocks as slower shells generated in the central engine prompt phase catch up with the afterglow shock at later times.Comment: 9 pages, 3 figures. Invited talk at the Swift-Venice 2006 meeting to be published by "Il Nuovo Cimento

Extracellular matrix remodeling and TGF-β1/Smad signaling in diabetic colon mucosa

Diabetes is associated with metabolic and functional alterations in the gut. Using an experimental model of streptozotocin (STZ)-induced diabetes in rodents, we analyzed the extracellular matrix (ECM) and TGF-β/Smad signaling in the colon mucosa. Male rats were divided into normal control, diabetic and insulin treated diabetic groups during 4 and 9 weeks. Sirius red staining showed marked increase in the extracellular matrix deposition in diabetic mucosa. High levels of fibrillar collagen (I and III) and fibronectin mRNAs were also detected with an imbalance between MMPs/TIMPs activities. Moreover, an increased mesenchymal cell proliferation together with an enhanced expression of myofibroblasts markers vimentin and α-SMA were observed. TGF-β/Smad signaling-related genes were determined using RT-PCR, Western blotting, and immunohistochemistry. Diabetic rats showed a significant up-regulation of TGF-β1, TGF-β receptors and the effectors p-Smad2/3 in the mucosa compared with control rats. Insulin treatment attenuated the stimulating effect of diabetes on colon ECM deposition and TGF-β/Smad signaling. In conclusion, the overall results showed a deregulation of the TGFβ1 pathway associated with the appearance of myofibroblasts and the accumulation of ECM in the mucosa of diabetic colon. These data provide the first in vivo evidence that TGF-β1/Smad is a key component of intestinal tissue remodeling in diabetes.Fil: D'arpino, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Fuchs, Alicia Graciela. Universidad Abierta Interamericana. Facultad de Medicina. Centro de Altos Estudios en Ciencias de la Salud; ArgentinaFil: Sanchez, Sara Serafina del V.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Honore, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia; Argentin

Pancytopenia in a patient with cryptococcus meningitis

No Abstract

The transitional millisecond pulsar IGR J18245-2452 during its 2013 outburst at X-rays and soft gamma-rays

IGR~J18245--2452/PSR J1824--2452I is one of the rare transitional accreting millisecond X-ray pulsars, showing direct evidence of switches between states of rotation powered radio pulsations and accretion powered X-ray pulsations, dubbed transitional pulsars. IGR~J18245--2452 is the only transitional pulsar so far to have shown a full accretion episode, reaching an X-ray luminosity of $\sim10^{37}$~erg~s$^{-1}$ permitting its discovery with INTEGRAL in 2013. In this paper, we report on a detailed analysis of the data collected with the IBIS/ISGRI and the two JEM-X monitors on-board INTEGRAL at the time of the 2013 outburst. We make use of some complementary data obtained with the instruments on-board XMM-Newton and Swift in order to perform the averaged broad-band spectral analysis of the source in the energy range 0.4 -- 250~keV. We have found that this spectrum is the hardest among the accreting millisecond X-ray pulsars. We improved the ephemeris, now valid across its full outburst, and report the detection of pulsed emission up to $\sim60$ keV in both the ISGRI ($10.9 \sigma$) and Fermi/GBM ($5.9 \sigma$) bandpass. The alignment of the ISGRI and Fermi GBM 20 -- 60 keV pulse profiles are consistent at a $\sim25\ \mu$s level. We compared the pulse profiles obtained at soft X-rays with \xmm\ with the soft \gr-ray ones, and derived the pulsed fractions of the fundamental and first harmonic, as well as the time lag of the fundamental harmonic, up to $150\ \mu$s, as a function of energy. We report on a thermonuclear X-ray burst detected with \Integ, and using the properties of the previously type-I X-ray burst, we show that all these events are powered primarily by helium ignited at a depth of $y_{\rm ign} \approx 2.7\times10^8$ g cm${}^{-2}$. For such a helium burst the estimated recurrence time of $\Delta t_{\rm rec}\approx5.6$ d is in agreement with the observations.Comment: 10 pages, 6 Figures, 3 Tables Astronomy and Astrophysics Journal, accepted for publication on the 13th of April 201