Professionsbezogenes Physiklernen im Lehramtsstudium: Entwicklung und Evaluation kumulativer Fachveranstaltungen

Eine physikalisch-fachliche Professionalisierung gilt in der Physik-Lehramtsausbildung als notwendig. Physik-Lehramtsstudierende sollten dabei gezielt auf die inhaltlichen Anforderungen der Schule vorbereitet werden, was jedoch selten erreicht wird (vgl. DPG 2014). Für unsere Studie wurden drei Physikveranstaltungen für Lehramtsstudierende anhand eines zuvor entwickelten Modells zum kumulativen Physiklehren und -lernen konzipiert, die den fachlichen Professionsbezug gewährleisten sollen. Der Beitrag stellt die Entwicklung der Lehrveranstaltungen und deren Evaluation vor. Die Kurse wurden bei zwei Kohorten mit  angehenden Physiklehrkräften an der Pädagogischen Hochschule Ludwigsburg eingesetzt. Für die Evaluation wurden Daten zum physikalischen Fachwissen erhoben und in einer vergleichenden Längsschnittstudie explorativ ausgewertet. Die Ergebnisse deuten darauf hin, dass der Erwerb von schulrelevantem physikalischem Wissen in der Intervention effizient erfolgt. Somit kann die kumulative Physiklehre als Modell für die Entwicklung von professionsorientierten Physikkursen in der Lehramtsausbildung dienen

The selection function of the RAVE survey

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The Decision Support System for improved Tsunami Early Warning in Indonesia: Approach and Implementation

In recent years numerous tsunami events in the Indian Ocean have shown how vulnerable human society and the environment is to this sudden-onset type of disaster. Especially the December 2004 tsunami demonstrated the need for an effective tsunami early warning system for the Indian Ocean. The German-Indonesian Early Warning System (GITEWS) project uses the best sensor technologies available today to detect indicators or evidence for a tsunami, combining those information with up-to-date modelling techniques and integrating them in a newly developed Decision Support System. Combining a-priori knowledge, simulation runs and analysis results with real-time information from different types of sensors, the newly developed Decision Support System (DSS) serve as a back-bone to allow an assessment for the tsunami threat at the earliest time possible and support the decision maker whether to issue a tsunami warning or not. GITEWS therefore adds additional components in order to achieve the best situation awareness possible by compiling a huge scenario-based repository of a-priori knowledge: A tsunami simulation system generates a large number of pre-calculated tsunami scenarios; in case of a potential tsunami, sensor observations can be compared and matched with these scenarios in order to find the most likely tsunami scenario descriptions, and a risk and vulnerability analysis component that helps to assess probable consequences and impacts on coastal communities exposed to tsunamis. Once the decision to disseminate a warning has been made, the DSS is able to generate regionalized warning messages, which are then transmitted to different dissemination systems using the standardized Common Alerting Protocol (CAP)

Patient Characteristics and Outcomes of Relapsed/ Refractory Multiple Myeloma in Patients Treated with Proteasome Inhibitors in Germany

Introduction: Real-world data reflects treatments and outcomes in clinical practice in contrast with controlled clinical trials. This study evaluates real-life multiple myeloma (MM) patients receiving proteasome inhibitor (PI)-based treatments in the second or third therapy line in 2017 in Germany. Methods: This is a retrospective chart review on adult relapsed/refractory MM patients treated with ≥1 dose of a PI-based regimen in either the second or the third line of therapy. Participating physicians had ≥3 years of clinical experience in treating symptomatic MM patients and used PI according to the label. Results: Distinct patient profiles for each PI-based regimen emerged. Younger, fitter, transplant eligible patients received novel PI triplets such as carfilzomib in combination with lenalidomide and dexamethasone (KRd) or IRd. Patients receiving lenalidomide in first-line therapy mostly received lenalidomide-free regimens in secondline therapy. In high-risk patients, no clear treatment patterns could be ascertained. The complete response rates were highest with KRd (13.0%), followed by carfilzomib in combination with dexamethasone (Kd) (5.7%) and bortezomib (4.8%). The very good partial response rates were highest with IRd (76.9%), followed by KRd (53.7%), Kd (25.7%), and bortezomib (20.5%). None of the KRd- or IRd-treated patients responded below a partial response. Discussion/Conclusion: Clear patient profiles for each PI type were observed. In second-line therapy, younger, fitter, transplant-eligible patients received novel-PI-based triplets, e.g., KRd or IRd. Patients treated with lenalidomide in first-line therapy mostly received lenalidomide-sparing regimens in second-line therapy. In high-risk patients no clear treatment patterns could be ascertained due to the limited sample siz