Neglect matters: a multi-agency guide for professionals working together on behalf of teenagers

Neglect matters: a multi-agency guide for professionals working together on behalf of teenager

Cost Effective Legal Research

This article discusses free and low-cost legal research resources that can help reduce the cost of litigation. A lawyer using such resources must appreciate not only the advantages of such resources, but also the disadvantages

The 2011 February superoutburst of the dwarf nova SDSS J112003.40+663632.4

We report unfiltered photometry of SDSS J112003.40+663632.4 during the 2011 February outburst which revealed the presence of superhumps with peak-to-peak amplitude of up to 0.22 magnitudes showing this to be an SU UMa type dwarf nova. The outburst amplitude was 5.4 magnitudes above mean quiescence and it lasted at least 12 days. The mean superhump period during the plateau phase was Psh = 0.07057(19) d.Comment: Accepted for publication in the Journal of the British Astronomical Association. 12 pages, 5 figure

The transition to adulthood for young people leaving public care: international comparisons and perspectives.

Background A growing body of international research findings had revealed the poor outcomes for looked after children, in comparison to children who had not been in care, especially in relation to their education, health and wellbeing. These findings had also shown the high risk of social exclusion of young people making the transition from care to adulthood. They were far more likely than young people who had not been in care to have poorer educational qualifications, be younger parents, be homeless, and have higher levels of unemployment, offending behaviour and mental health problems. In 2003 a seminar held in Brussels brought together, for the first time, researchers from Europe, the Middle East, Canada and the United States, to begin to explore in depth the issues underpinning these research findings

A Platform for the Analysis of Qualitative and Quantitative Data about the Built Environment and its Users

There are many scenarios in which it is necessary to collect data from multiple sources in order to evaluate a system, including the collection of both quantitative data - from sensors and smart devices - and qualitative data - such as observations and interview results. However, there are currently very few systems that enable both of these data types to be combined in such a way that they can be analysed side-by-side. This paper describes an end-to-end system for the collection, analysis, storage and visualisation of qualitative and quantitative data, developed using the e-Science Central cloud analytics platform. We describe the experience of developing the system, based on a case study that involved collecting data about the built environment and its users. In this case study, data is collected from older adults living in residential care. Sensors were placed throughout the care home and smart devices were issued to the residents. This sensor data is uploaded to the analytics platform and the processed results are stored in a data warehouse, where it is integrated with qualitative data collected by healthcare and architecture researchers. Visualisations are also presented which were intended to allow the data to be explored and for potential correlations between the quantitative and qualitative data to be investigated

Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year followup in the West of Scotland Cancer Network

Clinically and biologically, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has much more in common with germinal-center derived B-cell non-Hodgkin lymphoma (NHL) than with classical Hodgkin lymphoma (cHL). Management of NLPHL remains controversial. In a 14-year multicenter series, 69 cases were analyzed, and the median follow-up was 53 months (range 11–165.) B-symptoms were present in only 4.3% of patients, and 81.1% of patients had stage I/II disease. Treatment was with radiotherapy (53.6%), chemotherapy (21.7%), combined modality (17.4%), and observation (7.2%). In all, 10.1% of patients relapsed and 2.9% of patients developed high-grade transformation to DLBCL. All relapses and transformations were salvageable. No patient died of their disease. The 5-year relapse-free survival was 92%, transformation-free survival 98.4%, and overall survival 100%. We conclude that NLPHL behaves as a distinct clinical entity, often presenting at an early stage without risk factors. It has an excellent outcome. It may be possible, in early-stage disease, to reduce the intensity of therapy in NLPHL, to single-modality radiotherapy, without affecting OS

Leaving care in Scotland : the residential experience

Each year over a thousand young people aged sixteen and over leave care in Scotland. What does leaving care mean for these young people and what happens to them in the early stages of post-care living? What has helped them to prepare for leaving care and how best can they be supported to achieve positive outcomes as they continue their transition to independent living? These questions formed the basis of a recent survey of young people who had moved on from the care of three Scottish local authorities (Dixon and Stein, 2002a; 2002b

Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells

A major obstacle to efficacious T cell-based cancer immunotherapy is the tolerizing-tumor microenvironment that rapidly inactivates tumor-infiltrating lymphocytes. In an autochthonous model of prostate cancer, we have previously shown that intratumoral injection of Ag-loaded dendritic cells (DCs) delays T cell tolerance induction as well as refunctionalizes already tolerized T cells in the tumor tissue. In this study, we have defined molecular interactions that mediate the effects of DCs. We show that pretreating Ag-loaded DCs with anti-CD70 Ab abolishes the ability of DCs to delay tumor-mediated T cell tolerance induction, whereas interfering with 4-1BBL, CD80, CD86, or both CD80 and CD86 had no significant effect. In contrast, CD80[superscript −/−] or CD80[superscript −/−]CD86[superscript −/−] DCs failed to reactivate already tolerized T cells in the tumor tissue, whereas interfering with CD70 and 4-1BBL had no effect. Furthermore, despite a high level of programmed death 1 expression by tumor-infiltrating T cells and programmed death ligand 1 expression in the prostate, disrupting programmed death 1/programmed death ligand 1 interaction did not enhance T cell function in this model. These findings reveal dynamic requirements for costimulatory signals to overcome tumor-induced tolerance and have significant implications for developing more effective cancer immunotherapies.American Cancer Society (Postdoctoral Fellowship 12109-PF-11-025-01-LIB)John D. Proctor Foundation (Margaret A. Cunningham Immune Mechanisms in Cancer Research Fellowship)United States. Army Medical Research and Materiel Command. Prostate Cancer Research Program (Grant

Focal And Aberrant Prefrontal Engagement During Emotion Regulation In Veterans With Posttraumatic Stress Disorder

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109312/1/da22243.pd