Analytical studies on commercial artists’ colour charts from Das Deutsche Farbenbuch (1925)—identification of synthetic and natural organic colourants by Raman microscopy, surface-enhanced Raman spectroscopy and metal underlayer ATR-FTIR spectroscopy

Historical colour charts provide a rich and often well-dated reference materials source for studying the chemical composition of all kinds of commercial brands of artists' paints. This article presents the results of an extensive analytical study of more than 80 paint hues from 11 colour charts that are included in the German standard book Das Deutsche Farbenbuch by H. Trillich (1925, Part II). Our research focused on the identification of synthetic organic pigments, whose quickly increasing significance for artists' paints in the early twentieth century is impossible to evaluate by documentary source research alone. A stepwise procedure combining different non- or minimally invasive vibrational spectroscopy techniques-Normal Raman and Surface-Enhanced Raman spectroscopy as well as Metal Underlayer Attenuated Total Reflection Fourier-transform Infrared Spectroscopy-allowed the identification of 18 different organic colourants in artists' watercolours, tempera and oil colours from six German manufacturers. In addition, micro-X-Ray Fluorescence spectroscopy was applied to determine the elemental pattern of substrates, fillers, and admixed inorganic pigments. In addition to a few traditional natural organic colourants (dark and rose madder lake, cochineal lake), most of the identified compounds comprised synthetic organic pigments or synthetic dyes from various chemical classes (indigo, anthraquinone, monoazo, ss-naphthol, xanthene, triarylcarbonium, nitroso, and azine compounds). Some of these have not or only rarely been reported in artists' paints so far. Since the identified organic colourants have mainly poor to fair (only sometimes good) fastness to light according to modern standards and partially also to solvents typically used in conservation treatments, it is evident that works of art from this period should be treated keeping in mind the possible presence of such colourants, when planning both interventive treatments and preventive measures

Subclinical salmonella infection in Danish finishing herds - prevalence of S. enterica measured by bacteriological and serological examination

Subclinically salmonella infected herds may represent a contamination risk for pork products although no clinical signs are present. In the nation-wide Salmonella enterica surveillance and control programme in Danish slaughter pig herds (Mousing et al. 1997) the salmonella prevalence in Danish pig herds is being monitored. The monitoring is based on serological examination of meat juice (Nielsen et al. 1997). Serological examination of blood samples and bacteriological examination of pen samples is used as follow-up

eHealth Literacy in German Skin Cancer Patients

The global incidence of skin cancer has steadily increased in recent years, and malignant melanoma still has one of the fastest-growing incidence rates among all malignant tumors in the western world. Thus, newly diagnosed patients have an increased need for health information concerning their disease. Using a standardized questionnaire, our study aims to investigate our patients’ primary sources of health-related information as well as their self-proclaimed eHealth literacy. We received 714 questionnaires. Regardless of age, the primary source of information was the treating dermato-oncologist, followed by the treating general practitioner and the Internet. However, with increasing age, the usage of the Internet decreased. Hence, younger participants were better equipped to find health-related information while using the Internet. Additionally, comprehending health-related information and gaining medical knowledge was significantly increased in better-educated participants. Overall, our study shows that with increased use of eHealth services, accessing web-based information increased, correlating with a better eHealth literacy of our patients. eHealth technologies are increasingly becoming more prevalent as a primary source of information in our modern health care system. Thus, it is crucial to educate cancer patients in eHealth literacy to make autonomous, informed decisions and gain more confidence in dealing with their disease

Subclinical salmonella infection in Danish finishing herds - association between serological and bacteriological testing

As part of the salmonella surveillance programme in Danish slaughter pig herds (Mousing et a!. 1997), the occurrence of subclinical salmonella infection in pigs is monitored serologically at slaughter by examination of meat juice samples, using a mix-ELISA (Nielsen eta!. 1997). Subsequently blood samples and pen (faecal) samples are used as diagnostic tests in infected herds. The association between the serological and the bacteriological testing therefore needs assessment. The objective of the present study was to assess the association between serological and bacteriological testing

Guidance on the Selection of Appropriate Indicators for Quantification of Antimicrobial Usage in Humans and Animals

An increasing variety of indicators of antimicrobial usage has become available in human and veterinary medicine, with no consensus on the most appropriate indicators to be used. The objective of this review is therefore to provide guidance on the selection of indicators, intended for those aiming to quantify antimicrobial usage based on sales, deliveries or reimbursement data. Depending on the study objective, different requirements apply to antimicrobial usage quantification in terms of resolution, comprehensiveness, stability over time, ability to assess exposure and comparability. If the aim is to monitor antimicrobial usage trends, it is crucial to use a robust quantification system that allows stability over time in terms of required data and provided output; to compare usage between different species or countries, comparability must be ensured between the different populations. If data are used for benchmarking, the system comprehensiveness is particularly crucial, while data collected to study the association between usage and resistance should express the exposure level and duration as a measurement of the exerted selection pressure. Antimicrobial usage is generally described as the number of technical units consumed normalized by the population at risk of being treated in a defined period. The technical units vary from number of packages to number of individuals treated daily by adding different levels of complexity such as daily dose or weight at treatment. These technical units are then related to a description of the population at risk, based either on biomass or number of individuals. Conventions and assumptions are needed for all of these calculation steps. However, there is a clear lack of standardization, resulting in poor transparency and comparability. By combining study requirements with available approaches to quantify antimicrobial usage, we provide suggestions on the most appropriate indicators and data sources to be used for a given study objective

Faster fixed-parameter tractable algorithms for matching and packing problems. In:

Abstract We obtain faster algorithms for problems such as r-dimensional matching and r-set packing when the size k of the solution is considered a parameter. We first establish a general framework for finding and exploiting small problem kernels (of size polynomial in k). This technique lets us combine Alon, Yuster and Zwick's colorcoding technique with dynamic programming to obtain faster fixed-parameter algo- rithms for these problems. Our algorithms run in time O(n + 2 O(k) ), an improvement over previous algorithms for some of these problems running in time O(n + k O(k) ). The flexibility of our approach allows tuning of algorithms to obtain smaller constants in the exponent

Evaluation of a nursing aftercare intervention for patients with head and neck cancer treated with chemoradiation

Head and neck cancer (HNC) patients treated with chemoradiation have to rediscover their life after recovering from severe side-effects and build-up self-confidence. To assist patients in this, an aftercare intervention to support patients’ self-management was implemented. This study aimed to evaluate the feasibility and first effects