Andreev levels spectroscopy of topological three-terminal junctions

We calculate the differential conductance at a probe inserted in the weak link of a topological Josephson junction, consisting of a semiconducting nanowire deposited on top of two separated superconductors. Our aim is to understand how the peculiar features in the spectrum of Andreev bound states, arising due to the presence of Majorana bound states at the ends of the two topological superconducting wires defining the junction, can be determined through a measurement of the differential conductance. We find that when the probe allows a single propagating mode, the differential conductance presents a dip at zero voltage of zero conductance close to the position where the spectrum exhibits the topologically protected crossing. This can be viewed as a signature of the presence of Majorana states, which does not require fermion parity conservation and is robust against parameters' changes, as well as disorder. On the contrary, when the probe allows two or more propagating modes the differential conductance resembles the spectrum of Andreev bound states. This has been established making use of both numerical and analytical methods.Comment: 10 pages, 10 figures, published versio

Thermopower of three-terminal topological superconducting systems

We study the thermopower of a three-terminal setup composed of a quantum dot attached to three electrodes, one of which is a topological superconductor. In the model, superconductivity is explicitly taken into account. We compare the results for s-wave (trivial) and p-wave (topological) superconductors and observe that for small temperatures the thermopower has different sign in the two cases. This behavior is strongly dependent on temperature and we estimate an energy scale that controls the sign in the p-wave case, which results proportional to the square root of the gap and the coupling to superconductor. The analytical results obtained with a simple 1D model are confirmed by a more realistic tight-binding model.Comment: 10 pages, 15 figures, published versio

Finite-frequency noise in a topological superconducting wire

In this paper we study the finite-frequency current cross-correlations for a topological superconducting nanowire attached to two terminals at one of its ends. Using an analytic 1D model we show that the presence of a Majorana bound state yields vanishing cross-correlations for frequencies larger than twice the applied transport voltage, in contrast to what is found for a zero-energy ordinary Andreev bound state. Zero cross-correlations at high frequency have been confirmed using a more realistic tight-binding model for finite-width topological superconducting nanowires. Finite-temperature effects have also been investigated.Comment: Contribution for the special issue of Physica E in memory of Markus B\"uttiker. 9 pages, 7 figure

Oxidative Stress and Vascular Damage in Hypertension: Role of Angiotensin II

Reactive oxygen species are oxygen derivates and play an active role in vascular biology. These compounds are generated within the vascular wall, at the level of endothelial and vascular smooth muscle cells, as well as by adventitial fibroblasts. In healthy conditions, ROS are produced in a controlled manner at low concentrations and function as signaling molecules regulating vascular contraction-relaxation and cell growth. Physiologically, the rate of ROS generation is counterbalanced by the rate of elimination. In hypertension, an enhanced ROS generation occurs, which is not counterbalanced by the endogenous antioxidant mechanisms, leading to a state of oxidative stress. In the present paper, major angiotensin II-induced vascular ROS generation within the vasculature, and relative sources, will be discussed. Recent development of signalling pathways whereby angiotensin II-driven vascular ROS induce and accelerate functional and structural vascular injury will be also considered

Separation of heat and charge currents for boosted thermoelectric conversion

In a multi-terminal device the (electronic) heat and charge currents can follow different paths. In this paper we introduce and analyse a class of multi-terminal devices where this property is pushed to its extreme limits, with charge $and$ heat currents flowing in different reservoirs. After introducing the main characteristics of such $heat-charge$ $current$ $separation$ regime we show how to realise it in a multi-terminal device with normal and superconducting leads. We demonstrate that this regime allows to control independently heat and charge flows and to greatly enhance thermoelectric performances at low temperatures. We analyse in details a three-terminal setup involving a superconducting lead, a normal lead and a voltage probe. For a generic scattering region we show that in the regime of heat-charge current separation both the power factor and the figure of merit $ZT$ are highly increased with respect to a standard two-terminal system. These results are confirmed for the specific case of a system consisting of three coupled quantum dots.Comment: 12 pages, 8 figure

Drug-induced hypertension: Know the problem to know how to deal with it

Arterial hypertension remains the world's leading mortality risk factor and despite overwhelming evidence that blood pressure-lowering strategies greatly reduce the cardiovascular risk, a substantial proportion of hypertensive individuals worldwide fail to achieve an optimal blood pressure control under treatment. Among the causes responsible for the gap existing between blood pressure lowering potential of the different antihypertensive treatments and real-life practice is the presence of drug-induced hypertension. Many therapeutic agents or substances may directly favour an increment of blood pressure values or counteract the blood pressure lowering effects of antihypertensive drugs. Excessive water and sodium retention, direct vasoconstriction or sympathomimetic activation are major mechanisms of action of such substances. The present manuscript will review medications and other substances that may increase blood pressure, also suggesting the choice of the more appropriate antihypertensive agents to employ when withdrawal of the substance or drug causing an elevation of blood pressure values is not possible