Agarsenone, a Cadinane Sesquiterpenoid from Commiphora erythraea

Agarsenone (1), a new cadinane sesquiterpenoid, was isolated from the resin of Commiphora erythraea. The structures of 1 and its decomposition products agarsenolides (2a and 2b) and myrrhone (3) were established by extensive NMR spectroscopic analysis. The absolute configuration of 3 and the relative and absolute configurations of 1 were assigned by comparison of experimental and calculated optical rotatory dispersion and electronic circular dichroism spectr

Robotic double-loop reconstruction method following total gastrectomy

Minimally invasive surgery for gastric cancer is a challenge. The reconstructive time is a particular issue and researchers have adopted a large variety of solutions and produced heterogeneous data. The reconstructive phase can be divided into two major categories based on the approach adopted: the execution of extracorporeal versus intracorporeal anastomosis. In turn, the surgical team can perform the latter with laparoscopic or robotic assistance. However, the question is, how should a robotic esophagojejunal anastomosis be performed after total gastrectomy? Most articles in the literature have reported the execution of mechanical anastomoses [1] [2] [3] [4] [5] [6], especially with circular staplers via the creation of a manual purse-string around the anvil. Other solutions have described the use of the Orvil or the overlap technique. Only three authors have reported intracorporeal sutures with a completely robotic-sewn anastomosis [7] [8] [9]. A new robotic technique (the Parisi technique) was developed and adopted at St. Mary’s Hospital, Terni, Italy. A double-loop reconstruction method with an intracorporeal robot-sewn anastomosis is performe

TG, FT-IR and NMR characterization of n-C16H34 contaminated alumina and silica after mechanochemical treatment

This paper deals with the application of mechanochemistry to model systems composed of alumina or silica artificially contaminated with n-C16H34. The mechanochemical treatment was carried out by means of a ring mill for times ranging from 10 to 40 h. Thermogravimetry and infrared and nuclear magnetic resonance spectroscopies were used for the characterization of the mechanochemical products. The results have indicated that, in the case of alumina, almost all the contaminant n-C16H34 undergoes a complex oxidative reaction path whose end products are strongly held on the surface. These end products are most likely made of crosslinked, partially oxidized hydrocarbon chains bond to the solid surface via COO− groups. In the case of silica, the hydrocarbon undergoes a different, equally complex reaction path, but to a lower extent. In this case the end products are most probably carbonylic compounds and graphitic carbon. Then, for both solid matrices, the mechanochemical treatment promotes significant modification of the chemical nature of the polluting hydrocarbon with end products much more difficult to remove from the surface. As the systems studied are models of sites contaminated by aliphatic hydrocarbon, the results are worthy of consideration in relation to the mobility of the contaminants in the environment

Laparoscopic peritoneal lavage. Our experience and review of the literature

NTRODUCTION: Over the years various therapeutic techniques for diverticulitis have been developed. Laparoscopic peritoneal lavage (LPL) appears to be a safe and useful treatment, and it could be an effective alternative to colonic resection in emergency surgery. AIM: This prospective observational study aims to assess the safety and benefits of laparoscopic peritoneal lavage in perforated sigmoid diverticulitis. MATERIAL AND METHODS: We surgically treated 70 patients urgently for complicated sigmoid diverticulitis. Thirty-two (45.7%) patients underwent resection of the sigmoid colon and creation of a colostomy (Hartmann technique); 21 (30%) patients underwent peritoneal laparoscopic lavage; 4 (5.7%) patients underwent colostomy by the Mikulicz technique; and the remaining 13 (18.6%) patients underwent resection of the sigmoid colon and creation of a colorectal anastomosis with a protective ileostomy. RESULTS: The 66 patients examined were divided into 3 groups: 32 patients were treated with urgent surgery according to the Hartmann procedure; 13 patients were treated with resection and colorectal anastomosis; 21 patients were treated urgently with laparoscopic peritoneal lavage. We had no intraoperative complications. The overall mortality was 4.3% (3 patients). In the LPL group the morbidity rate was 33.3%. CONCLUSIONS: Currently it cannot be said that LPL is better in terms of mortality and morbidity than colonic resection. These data may, however, be proven wrong by greater attention in the selection of patients to undergo laparoscopic peritoneal lavage

The influence of the media on COPD patients’ knowledge regarding cardiopulmonary resuscitation

Stefano Nava1, Carmen Santoro1, Mario Grassi2, Nicholas Hill31Respiratory Unit, Fondazione S Maugeri, I R C C S Istituto Scientifico di Pavia, Pavia, Italy; 2Department of Health Sciences, Section of Medical Statistics and Epidemiology, University of Pavia, Pavia, Italy; 3Pulmonary and Critical Care Division, Tufts University, New England Medical Center, Boston, MA, USABackground: The decision whether or not to undertake cardiopulmonary resuscitation (CPR) is a major ethical challenge. Patient preferences may be influenced by multiple factors, including information given by the media.Objectives: We wanted to assess whether patients’ knowledge about CPR survival and outcomes was related to presentation by the media.Methods: 100 consecutive patients with COPD and chronic respiratory failure (CRF) and 100 patients at their first hospital admission for respiratory problems were enrolled. A questionnaire was administered to the patients seeking to ascertain their exposure to health information from the media, and to obtain their opinions on 1) the probability of survival after CPR, 2) the maximal length of time from collapse to CPR that allows a reasonable chance of survival, and 3) long-term outcomes of CPR survivors.Results: The patients overestimated the success rate of CPR (63% of them estimated a hospital survival >40%), while the estimate of long-term outcome and timing of the procedure were more realistic. Bivariate correlations analysis showed significant correlation between the rate of correct responses and the viewing of educational television programs (p = 0.039), but not medical stories, reading of health-oriented newspapers, use of the internet, age, educational level, and the presence of CRF.Conclusions: In conclusion, we have shown that both COPD and “newly admitted” patients’ estimate of survival after CPR is much higher than reported by the current literature. A correct knowledge of CPR procedures and outcomes is significantly correlated with the exposure to “educational” medical TV programs, but not medical stories, newspapers, or internet sources.Keywords: cardiopulmonary resuscitation, chronic respiratory failure, chronic obstructive pulmonary disease, media, televisio

Exploring the depths of the global earth observation system of systems

Big Earth Data-Cube infrastructures are becoming more and more popular to provide Analysis Ready Data, especially for managing satellite time series. These infrastructures build on the concept of multidimensional data model (data hypercube) and are complex systems engaging different disciplines and expertise. For this reason, their interoperability capacity has become a challenge in the Global Change and Earth System science domains. To address this challenge, there is a pressing need in the community to reach a widely agreed definition of Data-Cube infrastructures and their key features. In this respect, a discussion has started recently about the definition of the possible facets characterizing a Data-Cube in the Earth Observation domain. This manuscript contributes to such debate by introducing a view-based model of Earth Data-Cube systems to design its infrastructural architecture and content schemas, with the final goal of enabling and facilitating interoperability. It introduces six modeling views, each of them is described according to: its main concerns, principal stakeholders, and possible patterns to be used. The manuscript considers the Business Intelligence experience with Data Warehouse and multidimensional "cubes" along with the more recent and analogous development in the Earth Observation domain, and puts forward a set of interoperability recommendations based on the modeling views

D4.2. Observation inventory description and results report

The ConnectinGEO Observation Inventory (OI) is created and populated using the current information in the metadata concentrated in the GEO Discovery and Access Broker (DAB) of the GEOSS Common Infrastructure (GCI) to analyse the observations and measurements currently available in it. WP4 defined a high-level process for the population of the Observation Inventory: (i) retrieve the full metadata content for each record in the GEO DAB, (ii) extract/Infer extra semantics (connecting to external knowledge systems when needed), and (iii) generate enriched metadata and write it to the OI. The OI system architecture was designed and developed. The first version of the OI was created and populated using the current information in the metadata concentrated in the GEO DAB. The first population process was run in December 2015, resulting in a total of more than 1.6M harvested metadata records. The developed OI is accessible online and can be used as a data source by different analysis tools, which create plots, report, or summary statistics useful for the ConnectinGEO gap analysis. A simple Web Client was developed to demonstrate how to interrogate the OI and provide also basic examples of how the developed OI can be used by web-based analysis tools