Winding Modes and Large Extra Dimensions

We review briefly the main features of the Large Extra Dimensions scenario in the framework of weakly coupled Type I string theory. Kaluza-Klein (KK) excitations of the graviton are expected, whereas no KK modes for the gauge bosons arise if the gauge group is tied to a D3-brane. In this scenario, typical signatures such as direct production of KK modes of the graviton at high-energy colliders could test the size of the compactified dimensions. We point out that contrary to what considered in the literature on the subject, in the general case of anisotropic compactification Winding Modes of the Standard Model gauge bosons could also be directly observable, thus further constraining the model

Sigma decomposition: the CP-odd Lagrangian

Journal of High Energy Physics 2016.4 (2016): 016 reproduced by permission of Scuola Internazionale Superiore di Studi Avanzati (SISSA)Artículo escrito por un elevado número de autores, sólo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiera, y los autores pertenecientes a la UAMIn Alonso et al., JHEP 12 (2014) 034, the CP-even sector of the effective chiral Lagrangian for a generic composite Higgs model with a symmetric coset has been constructed, up to four momenta. In this paper, the CP-odd couplings are studied within the same context. If only the Standard Model bosonic sources of custodial symmetry breaking are considered, then at most six independent operators form a basis. One of them is the weak-θ term linked to non-perturbative sources of CP violation, while the others describe CP-odd perturbative couplings between the Standard Model gauge bosons and an Higgs-like scalar belonging to the Goldstone boson sector. The procedure is then applied to three distinct exemplifying frameworks: the original SU (5) /SO (5) Georgi-Kaplan model, the minimal custodial-preserving SO (5) /SO (4) model and the minimal SU (3) / (SU (2) × U (1)) model, which intrinsically breaks custodial symmetry. Moreover, the projection of the high-energy electroweak effective theory to the low-energy chiral effective Lagrangian for a dynamical Higgs is performed, uncovering strong relations between the operator coefficients and pinpointing the differences with the elementary Higgs scenarioThe work of I.M.H. is supported by an ESR contract of the European Union network FP7 ITN INVISIBLES (Marie Curie Actions, PITN-GA-2011-289442). L.M. acknowledges partial support of the European Union network FP7 ITN INVISIBLES, of CiCYT through the project FPA2012- 31880, of the Spanish MINECO’s “Centro de Excelencia Severo Ochoa” Programme under grant SEV-2012-0249, and by a grant from the Simons Foundation. S.R. acknowledges partial support of the European Union network FP7 ITN INVISIBLES and of the COFIN program PRIN 2010. This work was partially performed at the Aspen Center for Physics, which is supported by National Science Foundation grant PHY-106629

The minimal linear sigma model for the Goldstone Higgs

In the context of the minimal SO(5) linear {\sigma}-model, a complete renormalizable Lagrangian -including gauge bosons and fermions- is considered, with the symmetry softly broken to SO(4). The scalar sector describes both the electroweak Higgs doublet and the singlet {\sigma}. Varying the {\sigma} mass would allow to sweep from the regime of perturbative ultraviolet completion to the non-linear one assumed in models in which the Higgs particle is a low-energy remnant of some strong dynamics. We analyze the phenomenological implications and constraints from precision observables and LHC data. Furthermore, we derive the d <= 6 effective Lagrangian in the limit of heavy exotic fermions

Bounds on heavy chiral fermions

We derive the low-energy electroweak effective lagrangian for the case of additional heavy, unmixed, sequential fermions. Present data still allow for the presence of a new quark and/or lepton doublet with masses greater than M_Z/2, provided that these multiplets are sufficiently degenerate. Deviations of the effective lagrangian predictions from a full one-loop computation are sizeable only for fermion masses close to the threshold M_Z/2. Some of the constraints on new sequential fermions coming from accelerator results and cosmological considerations are presented. We point out that the new fermions can significantly affect the production and decay rate into \gamma \gamma of the intermediate Higgs at LHC

On the IR/UV flavour connection in non-universal axion models

Non-universal axion models, with the Peccei-Quinn (PQ) symmetry acting on Standard Model (SM) fermions in a generation-dependent way, are typically accompanied by two different sources of flavour violation, dubbed here as infrared (IR) and ultraviolet (UV). The former is due to the flavour violating axion couplings to SM fermions, while the latter arises from the heavy degrees of freedom that UV complete the axion effective field theory. We point out that these two sources of flavour violation are directly related and exemplify this connection in a general class of non-universal axion model, based on a renormalizable DFSZ-like setup with two Higgs doublets (PQ-2HDM). We next discuss the interplay of axion flavour phenomenology with the signatures stemming from the heavy radial modes of the PQ-2HDM, including meson oscillation observables and charged lepton flavour violating decays. We emphasize the strong complementarity between flavour observables, LHC direct searches and standard axion physics.Comment: 33 pages, 5 figure

Phenomenology of symmetry breaking from extra dimensions

Motivated by the electroweak hierarchy problem, we consider theories with two extra dimensions in which the four-dimensional scalar fields are components of gauge boson in full space. We explore the Nielsen-Olesen instability for SU(N) on a torus, in the presence of a magnetic background. A field theory approach is developed, computing explicitly the minimum of the complete effective potential, including tri-linear and quartic couplings and determining the symmetries of the stable vacua. We also develop appropriate gauge-fixing terms when both Kaluza-Klein and Landau levels are present and interacting, discussing the interplay between the possible six and four dimensional choices. The equivalence between coordinate dependent and constant Scherk-Schwarz boundary conditions -associated to either continuous or discrete Wilson lines- is analyzed.Comment: 39 pages and 8 eps figures. Few changes in section

Italian real life experience with ibrutinib: Results of a large observational study on 77 relapsed/refractory mantle cell lymphoma

Although sometimes presenting as an indolent lymphoma, mantle cell lymphoma (MCL) is an aggressive disease, hardly curable with standard chemo-immunotherapy. Current approaches have greatly improved patients' outcomes, nevertheless the disease is still characterized by high relapse rates. Before approval by EMA, Italian patients with relapsed/refractory MCL were granted ibrutinib early access through a Named Patient Program (NPP). An observational, retrospective, multicenter study was conducted. Seventyseven heavily pretreated patients were enrolled. At the end of therapy there were 14 complete responses and 14 partial responses, leading to an overall response rate of 36.4%. At 40 months overall survival was 37.8% and progression free survival was 30%; disease free survival was 78.6% at 4 years: 11/14 patients are in continuous complete response with a median of 36 months of follow up. Hematological toxicities were manageable, and main extra-hematological toxicities were diarrhea (9.4%) and lung infections (9.0%). Overall, 4 (5.2%) atrial fibrillations and 3 (3.9%) hemorrhagic syndromes occurred. In conclusions, thrombocytopenia, diarrhea and lung infections are the relevant adverse events to be clinically focused on; regarding effectiveness, ibrutinib is confirmed to be a valid option for refractory/relapsed MCL also in a clinical setting mimicking the real world