Derailment detection and data collection in freight trains, based on a wireless sensor network

We report the development of a network of wireless ultralow-power sensors to be deployed on freight railway cars, with the main purpose of detecting derailment events and alerting the engineer in the cab of the leading locomotive. Because no power bus is available on freight cars, we plan to rely on energy scavenging from vibrations; therefore, minimization of the power consumption has been one of our main priorities. We have, therefore, focused on ultralow-power hardware and strived to reduce the time intervals during which it is in active mode, achieving an average power consumption of ~0.5 mW with an active cycle of ~20 ms every 2 s. We discuss the overall concept that we propose, including the self-initialization protocol and the communication strategy that we have developed, and present the results of measurements on a prototype network that we have implemented

Occurrence, biogenesis and sensory impact of methyl salicylate in Lugana wines

Lugana wines are produced in the winemaking regions of Veneto and Lombardia, employing Turbiana grapes grown in the proximity of the Garda Lake. Methyl salicylate (MeSA) has been reported as a potentially impactful compound in Lugana wines. The aim of this study was to evaluate the occurrence of MeSA in commercial Lugana wines, elucidate its formation during winemaking and aging, and assess its potential contribution to Lugana aroma. MeSA was quantified in a total of 93 samples including Lugana, Verdicchio (another Italian white wine produced in central Italy using Turbiana grapes locally referred to as Verdicchio), as well as other Italian white and red wines such as Corvina, Corvinone, Garganega, Sangiovese, Pinot nero, Pinot grigio. The results showed that Lugana showed an average concentration of MeSA of 50.6 µg/L, Verdicchio of 33.4 µg/L, while the rest of the wines showed concentration below 5 µg/L. These results indicate that MeSA can be considered a varietal marker of Lugana wines, as well as more in general of wines obtained from the Turbiana/Verdicchio varietal cluster. Concentration of free MeSA in Lugana grape must is however low, and experimental fermentations showed that MeSA was largely formed by yeast activity during alcoholic fermentation, which hydrolyzes the glycosidic precursors of MeSA present in the must to release the aglycone. Additional MeSA can be formed in wine during aging by acid hydrolysis of the glycosidic precursors. Finally, the olfactory threshold of MeSA in a commercial Lugana was estimated by BET method at 38 µg/L, suggesting that MeSA could play a role in Lugana aroma

Bubbles and outflows: the novel JWST/NIRSpec view of the z=1.59 obscured quasar XID2028

Quasar feedback in the form of powerful outflows is invoked as a key mechanism to quench star formation in galaxies, although direct observational evidence is still scarce and debated. Here we present Early Release Science JWST NIRSpec IFU observations of the z=1.59 prototypical obscured quasar XID2028: this target represents a unique test case to study QSO feedback at the peak epoch of AGN-galaxy co-evolution thanks to its existing extensive multi-wavelength coverage and massive and extended outflow detected both in the ionised and molecular components. With the unprecedented sensitivity and spatial resolution of JWST, the NIRSpec dataset reveals a wealth of structures in the ionised gas kinematics and morphology previously hidden in the seeing-limited ground-based data. In particular, we find evidence of interaction between the interstellar medium of the galaxy and the QSO-driven outflow and radio jet, which is producing an expanding bubble from which the fast and extended wind detected in previous observations is emerging. The new observations confirm the complex interplay between the AGN jet/wind and the ISM of the host galaxy, highlighting the role of low luminosity radio jets in AGN feedback, and showcase the new window opened by NIRSpec on the detailed study of feedback at high redshift.Comment: 12 pages, 11 figures, submitted to A&A. Comments welcom

Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database

: Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. STUDY REGISTRATION: This protocol was registered in clinicaltriasl.gov (NCT04282083)

Association of Upfront Peptide Receptor Radionuclide Therapy With Progression-Free Survival Among Patients With Enteropancreatic Neuroendocrine Tumors

open57noIMPORTANCE Data about the optimal timing for the initiation of peptide receptor radionuclide therapy (PRRT) for advanced, well-differentiated enteropancreatic neuroendocrine tumors are lacking. OBJECTIVE To evaluate the association of upfront PRRT vs upfront chemotherapy or targeted therapy with progression-free survival (PFS) among patients with advanced enteropancreatic neuroendocrine tumors who experienced disease progression after treatment with somatostatin analogues (SSAs). DESIGN, SETTING, AND PARTICIPANTS This retrospective, multicenter cohort study analyzed the clinical records from 25 Italian oncology centers for patients aged 18 years or older who had unresectable, locally advanced or metastatic, well-differentiated, grades 1 to 3 enteropancreatic neuroendocrine tumors and received either PRRT or chemotherapy or targeted therapy after experiencing disease progression after treatment with SSAs between January 24, 2000, and July 1, 2020. Propensity score matching was done to minimize the selection bias. EXPOSURES Upfront PRRT or upfront chemotherapy or targeted therapy. MAIN OUTCOMES AND MEASURES The main outcome was the difference in PFS among patients who received upfront PRRT vs among those who received upfront chemotherapy or targeted therapy. A secondary outcome was the difference in overall survival between these groups. Hazard ratios (HRs) were fitted in a multivariable Cox proportional hazards regression model to adjust for relevant factors associated with PFS and were corrected for interaction with these factors. RESULTS Of 508 evaluated patients (mean ([SD] age, 55.7 [0.5] years; 278 [54.7%] were male), 329 (64.8%) received upfront PRRT and 179 (35.2%) received upfront chemotherapy or targeted therapy. The matched group included 222 patients (124 [55.9%] male; mean [SD] age, 56.1 [0.8] years), with 111 in each treatment group. Median PFS was longer in the PRRT group than in the chemotherapy or targeted therapy group in the unmatched (2.5 years [95%CI, 2.3-3.0 years] vs 0.7 years [95%CI, 0.5-1.0 years]; HR, 0.35 [95%CI, 0.28-0.44; P < .001]) and matched (2.2 years [95% CI, 1.8-2.8 years] vs 0.6 years [95%CI, 0.4-1.0 years]; HR, 0.37 [95%CI, 0.27-0.51; P < .001]) populations. No significant differences were shown in median overall survival between the PRRT and chemotherapy or targeted therapy groups in the unmatched (12.0 years [95%CI, 10.7-14.1 years] vs 11.6 years [95%CI, 9.1-13.4 years]; HR, 0.81 [95%CI, 0.62-1.06; P = .11]) and matched (12.2 years [95% CI, 9.1-14.2 years] vs 11.5 years [95%CI, 9.2-17.9 years]; HR, 0.83 [95%CI, 0.56-1.24; P = .36]) populations. The use of upfront PRRT was independently associated with improved PFS (HR, 0.37; 95%CI, 0.26-0.51; P < .001) in multivariable analysis. After adjustment of values for interaction, upfront PRRT was associated with longer PFS regardless of tumor functional status (functioning: adjusted HR [aHR], 0.39 [95%CI, 0.27-0.57]; nonfunctioning: aHR, 0.29 [95%CI, 0.16-0.56]), grade of 1 to 2 (grade 1: aHR, 0.21 [95%CI, 0.12-0.34]; grade 2: aHR, 0.52 [95%CI, 0.29-0.73]), and site of tumor origin (pancreatic: aHR, 0.41 [95%CI, 0.24-0.61]; intestinal: aHR, 0.19 [95%CI, 0.11-0.43]) (P < .001 for all). Conversely, the advantage was not retained in grade 3 tumors (aHR, 0.31; 95%CI, 0.12-1.37; P = .13) or in tumors with a Ki-67 proliferation index greater than 10% (aHR, 0.73; 95%CI, 0.29-1.43; P = .31). CONCLUSIONS AND RELEVANCE In this cohort study, treatment with upfront PRRT in patients with enteropancreatic neuroendocrine tumors who had experienced disease progression with SSA treatment was associated with significantly improved survival outcomes compared with upfront chemotherapy or targeted therapy. Further research is needed to investigate the correct strategy, timing, and optimal specific sequence of these therapeutic options.openPusceddu, Sara; Prinzi, Natalie; Tafuto, Salvatore; Ibrahim, Toni; Filice, Angelina; Brizzi, Maria Pia; Panzuto, Francesco; Baldari, Sergio; Grana, Chiara M.; Campana, Davide; Davì, Maria Vittoria; Giuffrida, Dario; Zatelli, Maria Chiara; Partelli, Stefano; Razzore, Paola; Marconcini, Riccardo; Massironi, Sara; Gelsomino, Fabio; Faggiano, Antongiulio; Giannetta, Elisa; Bajetta, Emilio; Grimaldi, Franco; Cives, Mauro; Cirillo, Fernando; Perfetti, Vittorio; Corti, Francesca; Ricci, Claudio; Giacomelli, Luca; Porcu, Luca; Di Maio, Massimo; Seregni, Ettore; Maccauro, Marco; Lastoria, Secondo; Bongiovanni, Alberto; Versari, Annibale; Persano, Irene; Rinzivillo, Maria; Pignata, Salvatore Antonio; Rocca, Paola Anna; Lamberti, Giuseppe; Cingarlini, Sara; Puliafito, Ivana; Ambrosio, Maria Rosaria; Zanata, Isabella; Bracigliano, Alessandra; Severi, Stefano; Spada, Francesca; Andreasi, Valentina; Modica, Roberta; Scalorbi, Federica; Milione, Massimo; Sabella, Giovanna; Coppa, Jorgelina; Casadei, Riccardo; Di Bartolomeo, Maria; Falconi, Massimo; de Braud, FilippoPusceddu, Sara; Prinzi, Natalie; Tafuto, Salvatore; Ibrahim, Toni; Filice, Angelina; Brizzi, Maria Pia; Panzuto, Francesco; Baldari, Sergio; Grana, Chiara M.; Campana, Davide; Davì, Maria Vittoria; Giuffrida, Dario; Zatelli, Maria Chiara; Partelli, Stefano; Razzore, Paola; Marconcini, Riccardo; Massironi, Sara; Gelsomino, Fabio; Faggiano, Antongiulio; Giannetta, Elisa; Bajetta, Emilio; Grimaldi, Franco; Cives, Mauro; Cirillo, Fernando; Perfetti, Vittorio; Corti, Francesca; Ricci, Claudio; Giacomelli, Luca; Porcu, Luca; Di Maio, Massimo; Seregni, Ettore; Maccauro, Marco; Lastoria, Secondo; Bongiovanni, Alberto; Versari, Annibale; Persano, Irene; Rinzivillo, Maria; Pignata, Salvatore Antonio; Rocca, Paola Anna; Lamberti, Giuseppe; Cingarlini, Sara; Puliafito, Ivana; Ambrosio, Maria Rosaria; Zanata, Isabella; Bracigliano, Alessandra; Severi, Stefano; Spada, Francesca; Andreasi, Valentina; Modica, Roberta; Scalorbi, Federica; Milione, Massimo; Sabella, Giovanna; Coppa, Jorgelina; Casadei, Riccardo; Di Bartolomeo, Maria; Falconi, Massimo; de Braud, Filipp

Pension reform and household financial position

In recent times pension reforms oriented toward introducing or expanding pension funds or insurance have been implemented in many countries. The main reason for this change is to reinforce the sustainability of intergenerational redistribution due to the ageing of society. However, a secondary aim has also been that of helping the development of financial markets and expanding the role of the stock exchange. We will focus on developed countries and, more specifically, on European pension reforms. A number of questions arise concerning the impact of such reforms. In particular, we will deal with the change in household savings investment and with the impact that these reforms have on the financialisation of the economy

Wireless sensor network for derailment detection in freight trains powered from vibrations

We present a network of wireless ultra-low-power sensors with the main purpose of detecting the derailment of a freight car and alerting the engineer in the cab of the leading locomotive. Due to the lack of a power supply in freight cars, we plan to rely on energy scavenging from vibrations. This implies that the energy requirements of the system must be minimized, choosing ultra-low-power hardware and operating it in active mode only for a small fraction of the time. We discuss the approach that we are currently pursuing, focusing, in particular, on the choice of hardware and the communication protocol

Predicting the Impact of Compressor Flexibility Improvements on Heavy-Duty Gas Turbines for Minimum and Base Load Conditions

The increasing importance of renewable energy capacity in the power generation scenario, together with the fluctuating consumer energy demand, forces conventional fossil fuel power generation systems to promptly respond to relevant and rapid load variations and to operate under off-design conditions during a major fraction of their lives. In order to improve existing power plants’ flexibility in facing energy surplus or deficit, retrofittable solutions for gas turbine compressors are proposed. In this paper, two different operation strategies, variable inlet guide vanes (IGVs) and blow-off extraction (BO), are considered for enabling partial load and minimum environmental load operation, and thus to identify implementation opportunities in existing thermal power plants. A typical 15-stage F-class gas turbine compressor is chosen as a test case and some energy demand scenarios are selected to validate the adopted solutions. The results of an extensive 3D, steady, CFD analysis are compared with the measurements coming from an experimental campaign carried out in the framework of the European Turbo-Reflex project. It will be shown how the combined strategies can reduce gas turbine mass flow rate and power plant output, without significantly penalizing efficiency, and how such off-design performance figures can be reliably predicted by employing state-of-the-art CFD models

Predicting the Impact of Compressor Flexibility Improvements on Heavy-Duty Gas Turbines for Minimum and Base Load Conditions

The increasing importance of renewable energy capacity in the power generation scenario, together with the fluctuating consumer energy demand, forces conventional fossil fuel power generation systems to promptly respond to relevant and rapid load variations and to operate under off-design conditions during a major fraction of their lives. In order to improve existing power plants’ flexibility in facing energy surplus or deficit, retrofittable solutions for gas turbine compressors are proposed. In this paper, two different operation strategies, variable inlet guide vanes (IGVs) and blow-off extraction (BO), are considered for enabling partial load and minimum environmental load operation, and thus to identify implementation opportunities in existing thermal power plants. A typical 15-stage F-class gas turbine compressor is chosen as a test case and some energy demand scenarios are selected to validate the adopted solutions. The results of an extensive 3D, steady, CFD analysis are compared with the measurements coming from an experimental campaign carried out in the framework of the European Turbo-Reflex project. It will be shown how the combined strategies can reduce gas turbine mass flow rate and power plant output, without significantly penalizing efficiency, and how such off-design performance figures can be reliably predicted by employing state-of-the-art CFD models

Retrofittable Solutions Capability for Gas Turbine Compressors

The increasing introduction of renewable energy capacity has changed the perspective on the operation of conventional power plants, introducing the necessity of reaching extreme off-design conditions. There is a strong interest in the development and optimization of technologies that can be retrofitted to an existing power plant to enhance flexibility as well as increase performance and lower emissions. Under the framework of the European project TURBO-REFLEX, a typical F-class gas turbine compressor designed and manufactured by Ansaldo Energia has been studied. Numerical analyses were performed using the TRAF code, which is a state-of-the-art 3D CFD RANS/URANS flow solver. In order to assess the feasibility of lower minimum environmental load operation, by utilizing a reduction in the compressor outlet mass-flow rate, with a safe stability margin, two different solutions have been analyzed: blow-off extractions and extra-closure of Variable Inlet Guide Vanes. The numerical steady-state results are compared and discussed in relation to an experimental campaign, which was performed by Ansaldo Energia. The purpose is to identify the feasibility of the technologies and implementation opportunity in the existing thermal power plant fleet