Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

ARTERIOGRAPHIE ULTRASONIQUE: Aorto-périphérique.

La maladie artérielle des membres inférieurs touche un grand nombre de personnes. Ils souffrent de douleurs à la marche (claudication intermittente) voir de douleurs de repos avec ou sans plaies cutanées. L'artériographie de contraste reste le "Gold Standard", mais c'est un examen invasif avec son lot de complications. L'artériographie ultrasonique est un examen échographique permettant, d'une part, de visualiser des lésions et, d'autres part, de fournir des informations hémodynamiques. Cette examen est fiable et inoffensif. Il peut être répétée autant de fois qu'on le désire. La singularité de cet ouvrage est d'être lu très facilement, mais aussi d'être didactique avec des schémas, des dessins et des images pour chaque segment artériel des membres inférieurs. Ce livre a pour vocation d'être pédagogique pour les jeunes praticiens tant en radiologie que pour les chirurgiens qui sont impliqués dans la prise en charge des patients porteurs d'une artérite des membres inférieurs. Ce livre a été rédigé pour qu'il soit utilisé dans la pratique au quotidien et que l'artériographie ultrasonique devienne une référence pour l'examen systématique de dépistages des lésions artérielles des membres inférieurs.info:eu-repo/semantics/publishe

Acute aortic dissection after off-pump coronary artery surgery.

Iatrogenic aortic dissection has been described, albeit infrequently, after coronary artery surgery performed under cardiopulmonary bypass. Since the advent of beating heart coronary surgery, several authors have described an apparent increase of this complication related to the application of a lateral clamp on the ascending aorta to perform the proximal anastomosis. We describe the case of a 70 years old patient who presented aortic dissection, with immediate paraplegia, 7 days after off-pump coronary surgery.Case ReportsJournal Articleinfo:eu-repo/semantics/publishe

Lack of effect of somatostatin and analogues in lymphorrhagia from ruptured thoracic duct [10]

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Popliteal artery pseudo-aneurysm and hereditary multiple exostoses.

We describe a rare case of a 21-year-old man presenting with hereditary multiple exostosis and a pseudoaneurysm of the popliteal artery caused by femoral osteochondroma. Principles of management and surgical technique are discussed.Case ReportsJournal Articleinfo:eu-repo/semantics/publishe

Effects of a chronic aortopulmonary shunt on pulmonary hemodynamics in piglets

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Long-term durability of three mechanical valves.

Case ReportsCommentLetterSCOPUS: le.jinfo:eu-repo/semantics/publishe

Typical features of constrictive pericarditis in a woman admitted for ascites.

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Pulmonary vascular impedance vs. resistance in hypoxic and hyperoxic dogs: Effects of propofol and isoflurane

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Recurrent endocarditis of a bicuspid aortic valve due to Q fever.

A 46-year-old man was referred to our institution for a recurrent endocarditis with negative blood culture. Clinical examination and complementary investigations confirmed the diagnosis of aortic valve endocarditis with left ventricular fistula. Blood culture was negative but serological tests were positive for Coxiella burnetti. Aortic valve replacement and fistula repair were done. A combination of Doxycycline and Chloroquine antibiotics was given postoperatively with a clinical improvement. Coxiella burnetti should be systemically searched for in all cases of endocarditis even with negative blood cultures. This case is interesting because of its rarity, diagnosis, therapeutic problems and its severe complication.Case ReportsJournal Articleinfo:eu-repo/semantics/publishe