Digital manufacturing in fiat group automobiles: virtual simulations for preliminary ergonomics optimization of workcells in the design phase of a new car model

New standards on work organization in the automotive industry, require a new concept of design methods: the human centred process. In Fiat Group Automobiles (FGA) the “Digital Manufacturing” (DM) project has started with the goal to create simulation tools and methods to improve the design of new cars’manufacturing processes giving a special attention to manual operations. The DM approach is based on a detailed “virtual plant” where virtual mannequins interact with digital models of car’s components, equipment, containers, etc. in order to simulate and improve working conditions with many benefits on ergonomics, safety, final product quality, work organization and general production costs. The key factor for this approach is that with DM methodologies, designers and engineers have, already in the design phase of a new car’s manufacturing process, a preliminary estimation of the numerical indices used in the plants to check if workcells are compliant to international standards and regional safety laws. In this way the most important ergonomic indices (like Niosh, Snook & Ciriello, EAWS, etc.) become a “design tool” that allow to change/improve project solutions (designing easy and comfortable work tasks, equipment, tools, etc.) and to distribute the work load in an optimal way between workers

Stara retorika in nova sredstva: Karantenske ladje kot sredstvo eksternalizacije

The article aims to illustrate and explore the rhetoric and institutional approach toward migrants – asylum seekers in particular – undertaken by Italy following the COVID-19 crisis. Through the account of the different “narrative phases” and the consequent institutional action undertaken, this article intends to demonstrate how the health crisis has sharpened and even intensified pre-existing attitudes and practices. The actions taken in the last year can be understood as a further step in the process of externalizing the borders. Through the instrumental use of rhetoric and illegitimate practices, a sort of de-territorialization has been implemented through the use of quarantine ships.Članek ilustrira in analizira verbalni in institucionalni pristop Italije do migrantov, še zlasti prosilcev za azil, med pandemijo covida-19. Z opisi različnih »vsebinskih faz« in posledičnih institucionalnih dejavnosti prikazuje, kako je zdravstvena kriza zaostrila in celo okrepila že obstoječe pristope in prakse. Aktivnosti prejšnjega leta lahko razumemo kot nadaljnji korak v procesu eksternalizacije meja. Država je z instrumentalizacijo verbalnih in nezakonitih praks izvedla nekakšno deteritorializacijo, ki temelji na uporabi karantenskih ladij

Applications and benefits of digital human models to improve the design of workcells in car’s manufacturing plants according to international standards

During last years, the car’s manufacturing process has deeply changed because of several factors affected the automotive global scenario. As a consequence, design methodologies of the plant’s workcells have changed. In particular, ergonomics for manufacturing system has become a key factor to improve product’s quality, safety and work organization. In this paper, the authors show the approach used in Fiat Group Automobiles (FGA) based on simulation tools to analyse ergonomic aspects of work-cells already in design phase. Simulation tools allow a deep postural analysis that is one of the main criticism in the design phase. The principles of Digital Human Modeling have been used to develop an easy internal virtual manikin, the Human Model. The tool, based on ISO standards and on a worldwide anthropometric database, allows designers to simulate the most probable postures engaged by operator during work tasks as well as to validate improvements and corrective actions

Human centred manufacturing: methodology for ergonomic previsional evaluation of manual assembly operations

The challenge of flexibility and productivity for manufacturing operations needs a new concept based on “human-centered manufacturing process”. This concept must consider basically the ergonomics of workplaces and workload balancing. The application of this concept is achievable through the detailed knowledge of the interaction between human and workplace, in particular as far as the mechanical load (or work load) arising from product design and from manufacturing process definition (included tools and equipment). The measurement of workload then is a fundamental for new (and existing) workplaces. In this paper is described the methodology that considers the procedure and instruments for measuring ergonomic parameters and the use of EAWS method to assess the ergonomic risk level of the workplace summarized by a score. EAWS considers postural aspects and dynamics of work activity. Design or modification of the workplace can be defined on base of the results obtained by the methodology application

Antropologia medica applicata at home

This contribution aims to reflect on personal tensions emerged from an action-research carried out within a public hospital’s gynecology unit located in north western Italy. I got involved on this fieldwork in two different ways: both as a Ph.D. researcher, willing to investigate the capability of informed consent to protect or not migrant patients’ right to health, and as an anthropologist-tutor having a specific educative responsibility - identifying critical situations in the relations between health care professionals and migrant patients in order to develop more equal relationships of care. More specifically I analyze the relationship among three ethically relevant topics such as: doing research "at home", the dialogue between subjectivity and experience and the challenging concretization of an appropriate methodology in anthropology. Starting from the ethical dilemmas emerged in fieldwork  I want to reflect on the political dimensions of being and researching "at home", on anthropology's public role and on the lack of recognition of the practitioner anthropologist and his/her work's legitimacy in this field

A Simple Multibody 2d-model for Early Postural Checks in Workplace Design

Posture prediction is one of the most important aspects of virtual modeling tools used for the workplace design: once the work point to reach is defined, the posture prediction module allows simulating, through inverse kinematics, the posture the operator is likely to assume. The paper presents a simple multibody 2D-model created for early postural checks in the design phase. The tool is a spreadsheet created in Microsoft Excel environment, with the support of Visual Basic. The principal output of the model in terms of angles of trunk bending and upper arm elevation, set in compliance with the technical standards, are compared to the results of an established software tool for ergonomic analyses, the 3D Static Strength Prediction Program (3DSSPP). Finally, possible differences in terms of moments on the L5/S1 and the shoulder joints introduced by the simplified kinematics of the 2D manikin are discussed

Investigation into the applicability of a passive upper-limb exoskeleton in automotive industry

The fourth industrial revolution faces the technological challenge of human-robot cooperation in manufacturing process. Aim of this study was to investigate the effectiveness and user’s acceptance of a passive exoskeleton for upper limbs. Three different tests, involving static and dynamic tasks, were performed by 29 automotive operators without and with the exoskeleton. Main aspects and results of the testing campaign are presented in the paper. Potential issues associated to the introduction of these auxiliary devices in the automotive industry are briefly addressed, together with the open questions on how to assess the biomechanical workload risk, especially in the design phase

Validation of the ONKOTEV Risk Prediction Model for Venous Thromboembolism in Outpatients With Cancer

Importance: The assessment of the risk of venous thromboembolism (VTE) among outpatients with cancer represents an unsolved topic. Current international guidelines recommend primary prophylaxis for patients at intermediate to high risk of VTE, indicated by a Khorana score of 2 or more. A previous prospective study developed the ONKOTEV score, a 4-variable risk assessment model (RAM) consisting of a Khorana score of more than 2, metastatic disease, vascular or lymphatic compression, and previous VTE event. Objective: To validate the ONKOTEV score as a novel RAM to assess the risk of VTE among outpatients with cancer. Design, setting, and participants: ONKOTEV-2 is a noninterventional prognostic study conducted in 3 European centers located in Italy, Germany, and the United Kingdom among a prospective cohort of 425 ambulatory patients with a histologically confirmed diagnosis of a solid tumor who were receiving active treatments. The total study duration was 52 months, with an accrual period of 28 months (from May 1, 2015, to September 30, 2017) and an overall follow up-period of 24 months (data were censored September 30, 2019). Statistical analysis was performed in October 2019. Exposures: The ONKOTEV score was calculated for each patient at baseline by collecting clinical, laboratory, and imaging data from tests performed for routine practice. Each patient was then observed to detect any thromboembolic event throughout the study period. Main outcomes and measures: The primary outcome of the study was the incidence of VTE, including deep vein thrombosis and pulmonary embolism. Results: A total of 425 patients (242 women [56.9%]; median age, 61 years [range, 20-92 years]) were included in the validation cohort of the study. The cumulative incidences for the risk of developing VTE at 6 months were 2.6% (95% CI, 0.7%-6.9%), 9.1% (95% CI, 5.8%-13.2%), 32.3% (95% CI, 21.0%-44.1%), and 19.3% (95% CI, 2.5%-48.0%), respectively, among 425 patients with an ONKOTEV score of 0, 1, 2, and greater than 2 (P < .001). The time-dependent area under the curve at 3, 6, and 12 months was 70.1% (95% CI, 62.1%-78.7%), 72.9% (95% CI, 65.6%-79.1%), and 72.2% (95% CI, 65.2%-77.3%), respectively. Conclusions and relevance: This study suggests that, because the ONKOTEV score has been validated in this independent study population as a novel predictive RAM for cancer-associated thrombosis, it can be adopted into practice and into clinical interventional trials as a decision-making tool for primary prophylaxis

Addressing the Role of Angiogenesis in Patients with Advanced Pancreatic Neuroendocrine Tumors Treated with Everolimus: A Biological Prospective Analysis of Soluble Biomarkers and Clinical Outcomes

Simple Summary Despite the approval of new targeted therapies for pancreatic neuroendocrine tumors (PanNETs) over the past decades, the early identification of resistant tumors remains the major challenge, mainly because clear signs of tumor shrinkage are rarely achieved by imaging assessment. Starting from the hypothesis that angiogenesis can be implicated in the resistance to mTOR inhibitors, we evaluated a specific angiogenesis panel (through the measurement of soluble biomarkers for angiogenesis turnover, circulating endothelial cells, and circulating progenitors) as possible predictors of resistance to everolimus or everolimus efficacy in PanNETs. Our study showed that none of the investigated categories of biomarkers had a predictive value for everolimus resistance or efficacy. However, we suggest that circulating endothelial progenitors might be surrogate biomarkers for angiogenesis activity in PanNETs during everolimus treatment, and their baseline levels might correlate with survival outcomes. These data have never been reported before for NETs. Background: The success of targeted therapies in the treatment of pancreatic neuroendocrine tumors has emphasized the strategy of targeting angiogenesis and the PI3K/AKT/mTOR pathway. However, the major challenge in the targeted era remains the early identification of resistant tumors especially when the efficacy is rarely associated to a clear tumor shrinkage at by imaging assessment. Methods: In this prospective study (NCT02305810) we investigated the predictive and prognostic role of soluble biomarkers of angiogenesis turnover (VEGF, bFGF, VEGFR2, TSP-1) circulating endothelial cells and progenitors, in 43 patients with metastatic panNET receiving everolimus. Results: Among all tested biomarkers, we found a specific subpopulation of circulating cells, CD31+CD140b-, with a significantly increased tumor progression hazard for values less or equal to the first quartile. Conclusion: Our study suggested the evidence that circulating cells might be surrogate biomarkers of angiogenesis activity in patients treated with everolimus and their baseline levels can be correlated with survival. However, further studies are now needed to validate the role of these cells as surrogate markers for the selection of patients to be candidates for antiangiogenic treatments