Innovative interventions in support of innovation networks. A complex system perspective to public innovation policy and private technology brokering

The linear model of innovation has been superseded by a variety of theoretical models that view the innovation process as systemic, complex, multi-level, multi-temporal, involving a plurality of heterogeneous economic agents. Accordingly, the emphasis of the policy discourse has shifted over time. It has gone from a focus on direct public funding of basic research as an engine of innovation, to the creation of markets for knowledge goods, to, eventually, the acknowledgement that knowledge transfer very often requires direct interactions among innovating actors. In most cases, these interventions attempt to facilitate the match between “demand” and “supply” of the knowledge needed to innovate. A complexity perspective calls for a different framing, one focused on the fostering of process characterized by multiple agency levels, multiple temporal scales, ontological uncertainty and emergent outcomes. The article explores what it means to design interventions in support of innovation processes inspired by a complex systems perspective. It does so by analyzing two different examples of coordinated interventions: an innovative public policy funding networks of innovating firms, and a private initiative supporting innovation in the mechanical engineering industry thanks to the set up of a technology broker. Relying on two unique datasets recording the interactions of the various organizations involved in these interventions, the article combines social network analysis and qualitative research in order to investigate the dynamics of the networks and the roles and actions of specific actors in fostering innovation processes. Building upon this comparative analysis, some general implications for the design of coordinated interventions supporting innovation in a complexity perspective are derived.Innovation policy; local development policies; regional development policies; evaluation management

Brokeraggio tecnologico nel settore metalmeccanico in Emilia-Romagna: dal Parco Scientifico Tecnologico ex-SIPE a CRIT srl

This research proposes an investigation into the creation and the later development, in the Italian region of Emilia-Romagna, of a private company called CRIT Srl, constituted by a group of large and medium-sized mechanical firms. The purpose of CRIT is not only to act as a technology broker, but also to provide in-teraction spaces between firms, and to contribute to the establishment of new networks of firms, therefore acting as a scaffolding structure. The decision to set up CRIT, in 2000, emerged in the context of a project concerning the construction of a Science Park in Vignola (in the province of Modena) that had been discussed since the second half of the 1990s. After having outlined some important elements of the history of this project (PST ex-Sipe), we will examine the whole range of activities that CRIT had developed in the course of nine years, from 2000 to 2008. Over time, most of the services offered by CRIT, to member and non-member firms, underwent changes following the members’ proposals and their changing needs. This study is part of a wider research project, that investigates public policies and pri-vate interventions that sustain innovation in systems of SMEs. See Russo and Rossi (2009), Rossi, Russo, Sardo and Whitford (2009), Russo and Whitford (2009). The last paper, in particular, uses data that are presented in this work, and it analyzes the characteristics of the network created by CRIT’s actions.technology broker; science park; innovation

Everything and nothing: A critical review of the “social” in Innovation and Entrepreneurship studies

Over the past two decades we have witnessed growing academic and policy interest in phenomena such as social innovation and social entrepreneurship. In these instances, the “social” element has often been described as a new or rediscovered category, indicating a normative predisposition to “elevate” existing or emerging innovation and entrepreneurship processes by identifying and promoting socially-acceptable standards of behavior and goal-setting. While previous reviews on social innovation have focused on the historical development of the concept and its role in academic debate, this article critically reviews the place of the “social” in current mainstream Innovation and Entrepreneurship (I&E) studies. The aim is to understand how this literature has been evolving in relation to this element and to what extent this addition has promoted a radical shift in the research direction. Our review, based on selected articles from 16 I&E mainstream journals, advances a novel classification of the dominant approaches to the social dimension in I&E studies, identifying four main categories: disciplinary, integrationist, separationist, and essentialist. What emerges is that most I&E studies ignore, minimize, or compartmentalize the “social”, using it to extend existing frameworks rather than to evolve them. Indeed, while the “social” has been offering an avenue for critical views to challenge mainstream discourse, at present it does not seem to significantly affect the latter’s evolution

Everything and nothing: A critical review of the “social” in Innovation and Entrepreneurship studies

Over the past two decades we have witnessed growing academic and policy interest in phenomena such as social innovation and social entrepreneurship. In these instances, the “social” element has often been described as a new or rediscovered category, indicating a normative predisposition to “elevate” existing or emerging innovation and entrepreneurship processes by identifying and promoting socially-acceptable standards of behavior and goal-setting. While previous reviews on social innovation have focused on the historical development of the concept and its role in academic debate, this article critically reviews the place of the “social” in current mainstream Innovation and Entrepreneurship (I&E) studies. The aim is to understand how this literature has been evolving in relation to this element and to what extent this addition has promoted a radical shift in the research direction. Our review, based on selected articles from 16 I&E mainstream journals, advances a novel classification of the dominant approaches to the social dimension in I&E studies, identifying four main categories: disciplinary, integrationist, separationist, and essentialist. What emerges is that most I&E studies ignore, minimize, or compartmentalize the “social”, using it to extend existing frameworks rather than to evolve them. Indeed, while the “social” has been offering an avenue for critical views to challenge mainstream discourse, at present it does not seem to significantly affect the latter’s evolution.Over the past two decades we have witnessed growing academic and policy interest in phenomena such as social innovation and social entrepreneurship. In these instances, the “social” element has often been described as a new or rediscovered category, indicating a normative predisposition to “elevate” existing or emerging innovation and entrepreneurship processes by identifying and promoting socially-acceptable standards of behavior and goal-setting. While previous reviews on social innovation have focused on the historical development of the concept and its role in academic debate, this article critically reviews the place of the “social” in current mainstream Innovation and Entrepreneurship (I&E) studies. The aim is to understand how this literature has been evolving in relation to this element and to what extent this addition has promoted a radical shift in the research direction. Our review, based on selected articles from 16 I&E mainstream journals, advances a novel classification of the dominant approaches to the social dimension in I&E studies, identifying four main categories: disciplinary, integrationist, separationist, and essentialist. What emerges is that most I&E studies ignore, minimize, or compartmentalize the “social”, using it to extend existing frameworks rather than to evolve them. Indeed, while the “social” has been offering an avenue for critical views to challenge mainstream discourse, at present it does not seem to significantly affect the latter’s evolution

Mother and infant body mass index, breast milk leptin and their serum leptin values

Purpose: This study investigates correlations between mother and infant Body Mass Index (BMI), their serum leptin values and breast milk leptin concentration in early infancy. Subjects and Methods: We determined serum leptin values in 58 healthy infants and leptin values in their mothers’ breast milk, using radioimmunoassay (RIA). Infant and maternal anthropometrics were measured. Results: Median leptin concentration was 3.9 ng/mL (interquartile range (IQR): 2.75) in infant serum, 4.27 ng/mL (IQR: 5.62) in maternal serum and 0.89 ng/mL (IQR: 1.32) in breast milk. Median maternal BMI and weight were 24 kg/m2 (IQR: 4.41) and 64 kg (IQR: 15). Median infant BMI was 15.80 kg/cm2 (IQR: 4.02), while average weight was 5.130 kg (IQR: 1.627). Infants serum leptin values positively correlated with infants’ BMI (p = 0.001; r = 0.213) and breast milk leptin (p = 0.03; r = 0.285). Maternal serum leptin values positively correlated with maternal BMI (p = 0.000, r = 0.449) and breast milk leptin ones (p = 0.026; r = 0.322). Conclusion: Breast milk leptin and maternal BMI could influence infant serum leptin values. Further studies are needed to better elucidate the role of genetics and environment on infant leptin production and risk of obesity later in life

Protective effects of lemon nanovesicles: evidence of the Nrf2/HO-1 pathway contribution from in vitro hepatocytes and in vivo high-fat diet-fed rats

The cross-talk between plant-derived nanovesicles (PDNVs) and mammalian cells has been explored by several investigations, underlining the capability of these natural nanovesicles to regulate several molecular pathways. Additionally, PDNVs possess biological proprieties that make them applicable against pathological conditions, such as hepatic diseases. In this study we explored the antioxidant properties of lemon-derived nanovesicles, isolated at laboratory (LNVs) and industrial scale (iLNVs) in human healthy hepatocytes (THLE-2) and in metabolic syndrome induced by a high-fat diet (HFD) in the rat. Our findings demonstrate that in THLE-2 cells, LNVs and iLNVs decrease ROS production and upregulate the expression of antioxidant mediators, Nrf2 and HO-1. Furthermore, the in vivo assessment reveals that the oral administration of iLNVs improves glucose tolerance and lipid dysmetabolism, ameliorates biometric parameters and systemic redox homeostasis, and upregulates Nrf2/HO-1 signaling in HFD rat liver. Consequently, we believe LNVs/iLNVs might be a promising approach for managing hepatic and dysmetabolic disorders

Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma

The molecular pathways which promote lung cancer cell features have been broadly explored, leading to significant improvement in prognostic and diagnostic strategies. Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have dramatically altered the treatment approach for patients with metastatic non-small cell lung cancer (NSCLC). Latest investigations by using next-generation sequencing (NGS) have shown that other oncogenic driver mutations, believed mutually exclusive for decades, could coexist in EGFR-mutated NSCLC patients. However, the exact clinical and pathological role of concomitant genomic aberrations needs to be investigated. In this systematic review, we aimed to summarize the recent data on the oncogenic role of concurrent genomic alterations, by specifically evaluating the characteristics, the pathological significance, and their potential impact on the treatment approach