Landscape quality payments in Switzerland : the congruence between policy and preferences

Peer reviewedPublisher PD

Lake surface temperatures in a changing climate: a global sensitivity analysis

We estimate the effects of climatic changes, as predicted by six climate models, on lake surface temperatures on a global scale, using the lake surface equilibrium temperature as a proxy. We evaluate interactions between different forcing variables, the sensitivity of lake surface temperatures to these variables, as well as differences between climate zones. Lake surface equilibrium temperatures are predicted to increase by 70 to 85% of the increase in air temperatures. On average, air temperature is the main driver for changes in lake surface temperatures, and its effect is reduced by ~10% by changes in other meteorological variables. However, the contribution of these other variables to the variance is ~40% of that of air temperature, and their effects can be important at specific locations. The warming increases the importance of longwave radiation and evaporation for the lake surface heat balance compared to shortwave radiation and convective heat fluxes. We discuss the consequences of our findings for the design and evaluation of different types of studies on climate change effects on lakes

SGLT2 inhibitor therapy for transthyretin amyloid cardiomyopathy: early tolerance and clinical response to dapagliflozin.

AIMS Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve clinical outcomes in heart failure patients with reduced and preserved left ventricular ejection fraction (LVEF), but have not yet been investigated in transthyretin amyloid cardiomyopathy (ATTR-CM). This study aimed to evaluate tolerability, clinical outcomes, and changes in NT-proBNP levels and glomerular filtration rate (GFR) in ATTR-CM patients treated with dapagliflozin. METHODS AND RESULTS Patients with stable, tafamidis-treated ATTR-CM were retrospectively evaluated at the initiation of dapagliflozin and 3 months thereafter. Tafamidis-treated ATTR-CM patients without SGLT2i served as a reference cohort. Overall, SLGT2i therapy was initiated in 34 patients. Seventeen patients with stable disease on tafamidis, who were subsequently started on dapagliflozin, were included in the analysis. Patients selected for SGLT2i presented with signs of advanced disease, evidenced by higher Gillmore disease stage (stage ≥2: 53% vs. 27.5%; P = 0.041), baseline median NT-proBNP [median (IQR) 2668 pg/mL (1314-3451) vs. 1424 (810-2059); P = 0.038] and loop diuretic demand (76.5% vs. 45% of patients; P = 0.044), and lower LVEF (46.6 ± 12.9 vs. 53.7 ± 8.7%; P = 0.019) and GFR (51.8 ± 16.5 vs. 68.5 ± 18.6 mL/min; P = 0.037) compared with the reference cohort. At 3-month follow-up, a numerical decrease in NT-proBNP levels was observed in 13/17 (76.5%) patients in the dapagliflozin (-190 pg/mL, IQR: -1,028-71, P = 0.557) and 27/40 (67.5%) of patients in the control cohort (-115 pg/mL, IQR: -357-105, P = 0.551). Other disease parameters remained stable and no adverse events occurred. CONCLUSIONS In tafamidis-treated ATTR-CM patients, initiation of dapagliflozin was well tolerated. The efficacy of SGLT2i therapy in patients with ATTR-CM needs to be studied in randomized controlled trials

Interventional treatment of mitral valve regurgitation: an alternative to surgery?

Mitral regurgitation is a highly prevalent condition among elderly patients, affecting almost 10% of the general population aged 75 and older. Left untreated, severe mitral regurgitation results in high mortality and frequent hospitalisation for treatment of heart failure. Surgical treatment remains the first-line therapy for symptomatic, severe mitral regurgitation , especially for patients presenting with a primary aetiology. However, a high proportion of patients with mitral regurgitation are turned down for open-heart surgery, mainly due to advanced age, diminished left ventricular function and comorbidities. Thus, percutaneous treatment options have been recently developed as an alternative. In this article, we will review transcatheter interventional techniques at the level of the mitral valve, including implantation technique, indications and clinical results

Growth hormone prevents steroid-induced growth depression in health and uremia

Growth hormone prevents steroid-induced growth depression in health and uremia. Treatment with supraphysiological doses of corticosteroids results in protein wasting and impairment of growth, whereas exogenous growth hormone (GH) causes anabolism and improvement of growth. We wanted to know whether the growth depressing effects of methylprednisolone (MP) are more expressed in an organism which is chronically diseased and whether these effects can be counterbalanced by concomitant treatment with recombinant human growth hormone (rhGH). MP in doses from 1 to 9 mg/kg/day caused a dose dependent reduction of length gain, weight gain and weight gain/food intake ratio in 140 g healthy female Sprague-Dawley rats. Food intake was not affected by MP. This points to a change in food metabolism as a mechanism for growth impairment. In addition, treatment with MP inhibited endogenous GH secretion, documented by serum GH concentration profiles over seven hours, decreased IGF-1 serum concentration and disturbed growth cartilage plate architecture. Concomitant treatment with 2.5 to 20 IU/rhGH/kg/day prevented the negative effects of MP on growth in a dose dependent manner and normallized growth plate architecture. In uremic rats in which food efficiency and growth was already reduced, 6 mg MP/kg/day further decreased length gain and prevented weight gain completely by bringing the weight gain/food conversion ratio to the nadir. All effects of MP including reduction of muscle mass could be prevented by concomitant treatment with 10 IU rhGH/kg/day. The effects of MP and rhGH on food efficiency and growth in uremic animals were numerically nearly identical to those in pair fed and ad libitum fed controls, but this may be more relevant in the diseased organism in which basal growth is already suppressed

Below Average Midsummer to Early Autumn Precipitation Evolved Into the Main Driver of Sudden Scots Pine Vitality Decline in the Swiss Rhône Valley

The vitality of Scots pine (Pinus sylvestris L.) is declining since the 1990s in many European regions. This was mostly attributed to the occurrence of hotter droughts, other climatic changes and secondary biotic stressors. However, it is still not well understood which specific atmospheric trends and extremes caused the observed spatio-temporal dieback patterns. In the Swiss Rhône valley, we identified negative precipitation anomalies between midsummer and early autumn as the main driver of sudden vitality decline and dieback events. Whereas climate change from 1981 to 2018 did not lead to a reduced water input within this time of the year, the potential evapotranspiration strongly increased in spring and summer. This prolonged and intensified the period of low soil moisture between midsummer and autumn, making Scots pines critically dependent on substantial precipitation events which temporarily reduce the increased water stress. Thus, local climate characteristics (namely midsummer to early autumn precipitation minima) are decisive for the spatial occurrence of vitality decline events, as the lowest minima outline the most affected regions within the Swiss Rhône valley. Mortality events will most likely spread to larger areas and accelerate the decline of Scots pines at lower elevations, whereas higher altitudes may remain suitable Scots pine habitats. The results from our regional study are relevant on larger geographic scales because the same processes seem to play a key role in other European regions increasingly affected by Scots pine dieback events

Report 4: The Dissemination Potential of a European Network

The report that follows represents an extraordinary and unique exchange of information. Unfolding here are the capabilities for dissemination and exploitation in the EU-funded Thematic Network ‘Dietitians Implementing Education and Training Standards’ in Europe (DIETS). At the beginning of the Network there were 112 Partners and about 500 registered users of the DIETS website, but over a three-year period this has increased to 123 Partners and well over 1000 users. The activity of these Partners and their determination to publicise the Network and, more importantly, the role of the dietitian, has been immense and sometimes difficult to capture. However, captured in this report are the learning and change to practice that has resulted, as well as closer engagement between HEIs and their dietetic departments across Europe. Some of the good practice described here will be of value to others starting this type of journey. This network of HEIs, their dietetic colleagues and others will endure long after the DIETS Network has finished its work, largely due to the enthusiasm of the Partners and the social network that has been built and embedded. The ultimate benefit to dietitians, through education, lifelong learning and their contribution to nutritional health in Europe will continue to unfold

Report 1: building a technologically informed information and communication network in europe

This report represents an extraordinary and unique exchange of information across Europe through the creation of a website and learning how to use technology more effectively. Over the three-year period the capabilities conducted as part the EU funded Thematic Network „Dietitians Implementing Education and Training Standards‟ in Europe (DIETS) are presented here. The number of users registered to access the intranet (password-protected) section of the website grew rapidly from 0 at launch to 965 by the end of the third year. A great deal of learning and change to practice has resulted as well as closer engagement between HEIs and their dietetic departments across Europe. This Network of HEIs and their dietetic colleagues will endure long after the DIETS Network has finished its work, largely due to the enhanced ITC capabilities. The ultimate benefit to the dietetic profession, their education and lifelong learning and their contribution to nutritional health in Europe will continue to unfol

The influence of station density on climate data homogenization

Relative homogenization methods assume that measurements of nearby stations experience similar climate signals and rely therefore on dense station networks with high-temporal correlations. In developing countries such as Peru, however, networks often suffer from low-station density. The aim of this study is to quantify the influence of network density on homogenization. To this end, the homogenization method HOMER was applied to an artificially thinned Swiss network. Four homogenization experiments, reflecting different homogenization approaches, were examined. Such approaches include diverse levels of interaction of the homogenization operators with HOMER, and different application of metadata. To evaluate the performance of HOMER in the sparse networks, a reference series was built by applying HOMER under the best possible conditions. Applied in completely automatic mode, HOMER decreases the reliability of temperature records. Therefore, automatic use of HOMER is not recommended. If HOMER is applied in interactive mode, the reliability of temperature and precipitation data may be increased in sparse networks. However, breakpoints must be inserted conservatively. Information from metadata should be used only to determine the exact timing of statistically detected breaks. Insertion of additional breakpoints based solely on metadata may lead to harmful corrections due to the high noise in sparse networks