Flight-determined stability and control coefficients of the F-111A airplane

A complete set of linear stability and control derivatives of the F-111A airplane was determined with a modified maximum likelihood estimator. The derivatives were determined at wing sweep angles of 26 deg, 35 deg, and 58 deg. The flight conditions included a Mach number range of 0.63 to 1.43 and an angle of attack range of 2 deg to 15 deg. Maneuvers were performed at normal accelerations from 0.9g to 3.8g during steady turns to assess the aeroelastic effects on the stability and control characteristics. The derivatives generally showed consistent trends and reasonable agreement with the wind tunnel estimates. Significant Mach effects were observed for Mach numbers as low as 0.82. No large effects attributable to aeroelasticity were noted

Radiation protection by auxin analogues and antiviral agents

Cobalt 60 gamma radiation of male white mice to determine ability of auxin and antiviral agents to provide radiation protectio

The beginnings of geography teaching and research in the University of Glasgow: the impact of J.W. Gregory

J.W. Gregory arrived in Glasgow from Melbourne in 1904 to take up the post of foundation Professor of Geology in the University of Glasgow. Soon after his arrival in Glasgow he began to push for the setting up of teaching in Geography in Glasgow, which came to pass in 1909 with the appointment of a Lecturer in Geography. This lecturer was based in the Department of Geology in the University's East Quad. Gregory's active promotion of Geography in the University was matched by his extensive writing in the area, in textbooks, journal articles and popular books. His prodigious output across a wide range of subject areas is variably accepted today, with much of his geomorphological work being judged as misguided to varying degrees. His 'social science' publications - in the areas of race, migration, colonisation and economic development of Africa and Australia - espouse a viewpoint that is unacceptable in the twenty-first century. Nonetheless, that viewpoint sits squarely within the social and economic traditions of Gregory's era, and he was clearly a key 'Establishment' figure in natural and social sciences research in the first half of the twentieth century. The establishment of Geography in the University of Glasgow remains enduring testimony of J.W. Gregory's energy, dedication and foresight

Depression and All‐Cause Mortality in Persons with Diabetes Mellitus: Are Older Adults at Higher Risk? Results from the Translating Research Into Action for Diabetes Study

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107493/1/jgs12833.pd

The Changing California Coast: The Effect of a Variable Water Budget on Coastal Vegetation Succession

The land-ocean interface along the central coast of California is one of the most diverse biogeographic regions of the state. This area is composed of a species-rich mosaic of coastal grassland, shrubland, and forest vegetation types. An acceleration of conifer encroachment into shrublands and shrub encroachment into grasslands along the coast has been recently documented. These vegetation changes are believed to be driven primarily by fire suppression and changing grazing patterns. Climatic variables such as precipitation, fog, cloud cover, temperature, slope, and elevation also play an important role in vegetation succession. Our study area is located along the central California coast, which is characterized by a precipitation gradient from the relatively wetter and cooler north to the drier and warmer south. Some studies indicate changing fog patterns along this coast, which may greatly impact vegetation. A decrease in water availability could slow succession processes. The primary objective of this project is to determine if vegetation succession rates are changing for the study area and to identify climate and ecosystem variables which contribute to succession, specifically the transition among grassland, shrubland, and forest. To identify vegetation types and rates of succession, we classified two Landsat TM 5 scenes from 1985 to 2010 with a resulting overall accuracy of 82.4%. Vegetation succession was correlated to changes in maximum and minimum temperatures, precipitation, and elevation for each sub-region of the study area. Fog frequency was then compared between the northern and southern regions of the study area for determining the spatial relation between fog frequency and the percent of vegetation change

Work-Unit Absenteeism: Effects of Satisfaction, Commitment, Labor Market Conditions, and Time

Prior research is limited in explaining absenteeism at the unit level and over time. We developed and tested a model of unit-level absenteeism using five waves of data collected over six years from 115 work units in a large state agency. Unit-level job satisfaction, organizational commitment, and local unemployment were modeled as time-varying predictors of absenteeism. Shared satisfaction and commitment interacted in predicting absenteeism but were not related to the rate of change in absenteeism over time. Unit-level satisfaction and commitment were more strongly related to absenteeism when units were located in areas with plentiful job alternatives

Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence

<p>Abstract</p> <p>Background</p> <p>Flexible dosing of anticholinergics used for overactive bladder (OAB) treatment is a useful strategy in clinical practice for achieving a maximum effective and maximum tolerated level of therapeutic benefit. In this post hoc analysis we evaluated the efficacy and tolerability of trospium chloride treatment for urinary urge incontinence (UUI) with focus on flexible dosing.</p> <p>Methods</p> <p>The data came from a 12-week, randomised, double-blind, phase IIIb study in which 1658 patients with urinary frequency plus urge incontinence received trospium chloride 15 mg TID (n = 828) or 2.5 mg oxybutynin hydrochloride TID (n = 830). After four weeks, daily doses were doubled and not readjusted in 29.2% (242/828) of patients in the trospium group, and in 23.3% (193/830) in the oxybuytnin group, until the end of treatment. We assessed the absolute reduction in weekly UUI episodes and the change in intensity of dry mouth, recorded in patients' micturition diaries. Adverse events were also evaluated. Statistics were descriptive.</p> <p>Results</p> <p>Dose escalation of either trospium or oxybutynin increased reduction in UUI episodes in the population studied. At study end, there were no relevant differences between the "dose adjustment" subgroups and the respective "no dose adjustment" subgroups (trospium: <it>P </it>= 0.249; oxybutynin: <it>P </it>= 0.349). After dose escalation, worsening of dry mouth was higher in both dose adjusted subgroups compared to the respective "no dose adjustment" subgroups (<it>P </it>< 0.001). Worsening of dry mouth was lower in the trospium groups than in the oxybutynin groups (<it>P </it>< 0.001). Adverse events were increased in the dose adjusted subgroups.</p> <p>Conclusions</p> <p>Flexible dosing of trospium was proven to be as effective, but better tolerated as the officially approved adjusted dose of oxybutynin.</p> <p>Trial registration (parent study)</p> <p>The study was registered with the German Federal Institute for Drugs and Medical Devices (BfArM, Berlin, Germany), registration number 4022383, as required at the time point of planning this study.</p