Plant density of year-round chrysanthemums.

Spider-type chrysanthemums on 2 commercial holdings were grown at densities of 40, 54, 60, 64, 70 or 80 plants/m of bed and at 27, 32, 40, 48, 54 or 60 plants/m of bed. In both cases the beds were 1.25 m wide. As density increased the average number of flowers/stem and the percentage of first quality grade stems decreased. During the winter months the quality of flowers from closely planted beds was noticeably poor and cropping was delayed and not uniform. A spacing of 40-50 plants/m would seem suitable for commercial use. (Abstract retrieved from CAB Abstracts by CABI’s permission

The Trap of History: The States Party and the Revolt of the Netherlands, 1650–1660

Historians of the First Stadholderless Period (1650-1672) have shown that supporters of the house of Orange evoked memories of Prince William i of Orange's role in the Revolt of the Netherlands in support of their political agendas. Jill Stern has recently argued that the supporters of True Freedom therefore needed to develop an alternative interpretation of the Revolt. Since she focuses on Orangist rhetoric, she has not asked why authors who sympathized with the States Party related their political ideology to the existing popular historical narratives about the conflict. These were, after all, tainted by Orangist associations. This article will argue that the past was a rich source of inspiration for politicians in the seventeenth-century 'present' but that the use of historical references was limited by the existing dominant storylines.Collective identities and transnational networks in medieval and early modern Europe, 1000-180

Memory wars in the Low Countries, 1566-1700

In 1566, the Revolt of the Netherlands against the Habsburg overlord Philip II of Spain erupted. The conflict broke the Low Countries in two parts: the Dutch Republic in the North and the Habsburg Netherlands in the South. In these two polities, two radically different narratives about the conflict emerged. Throughout the seventeenth century, people in the North remembered the Revolt as a successful struggle for freedom while inhabitants of the South remembered the conflict less vividly. Historians of the Dutch Republic have shown that in the North a canonical narrative arose about the origins of the conflict. Since they rest on the nationalist-inspired assumption that this was a self-evident development, they have left unaddressed the question of how and why such a narrative came into being. Historians of the Habsburg Netherlands have interpreted the 'silences' in the South as proof that, there, people had forgotten the rebellion. There are no comparative studies that try to explain why and how memories of the past diverged. This study examines how and why such conflicting interpretations of the Revolt arose, why they remained relevant throughout the seventeenth century, and what role memories of the Revolt played in Northern and Southern identity formation.Collective identities and transnational networks in medieval and early modern Europe, 1000-180

Dynastic scenario thinking in the Holy Roman Empire

NWO275-69-012Collective identities and transnational networks in medieval and early modern Europe, 1000-180

Intravascular palpography for high-risk vulnerable plaque assessment.

Item does not contain fulltextBACKGROUND: The composition of an atherosclerotic plaque is considered more important than the degree of stenosis. An unstable lesion may rupture and cause an acute thrombotic reaction. Most of these lesions contain a large lipid pool covered by an inflamed thin fibrous cap. The stress in the cap increases with decreasing cap thickness and increasing macrophage infiltration. Intravascular ultrasound (IVUS) palpography might be an ideal technique to assess the mechanical properties of high-risk plaques. TECHNIQUE: Palpography assesses the local mechanical properties of tissue using its deformation caused by the intraluminal pressure. IN VITRO VALIDATION: The technique was validated in vitro using diseased human coronary and femoral arteries. Especially between fibrous and fatty tissue, a highly significant difference in strain (p = 0.0012) was found. Additionally, the predictive value to identify the vulnerable plaque was investigated. A high-strain region at the lumen-vessel wall boundary has an 88% sensitivity and 89% specificity for identifying such plaques. IN VIVO VALIDATION: In vivo, the technique was validated in an atherosclerotic Yucatan minipig animal model. This study also revealed higher strain values in fatty than fibrous plaques (p < 0.001). The presence of a high-strain region at the lumenplaque interface has a high predictive value to identify macrophages. PATIENT STUDIES: Patient studies revealed high-strain values (1-2%) in thin-cap fibrous atheroma. Calcified material showed low strain values (0-0.2%). With the development of three-dimensional (3-D) palpography, identification of highstrain spots over the full length of a coronary artery becomes available. CONCLUSION: Intravascular palpography is a unique tool to assess lesion composition and vulnerability. The development of 3-D palpography provides a technique that may develop into a clinical tool to identify the high-risk plaque

Feedback on end-of-life care in dementia: the study protocol of the FOLlow-up project

Geriatrics in primary car

A supernova constraint on bulk majorons

In models with large extra dimensions all gauge singlet fields can in principle propagate in the extra dimensional space. We have investigated possible constraints on majoron models of neutrino masses in which the majorons propagate in extra dimensions. It is found that astrophysical constraints from supernovae are many orders of magnitude stronger than previous accelerator bounds. Our findings suggest that unnatural types of the "see-saw" mechanism for neutrino masses are unlikely to occur in nature, even in the presence of extra dimensions.Comment: Minor changes, matches the version to appear in PR

Diets with high or low protein content and glycemic index for weight-loss maintenance

BACKGROUND: Studies of weight-control diets that are high in protein or low in glycemic index have reached varied conclusions, probably owing to the fact that the studies had insufficient power. METHODS: We enrolled overweight adults from eight European countries who had lost at least 8% of their initial body weight with a 3.3-MJ (800-kcal) low-calorie diet. Participants were randomly assigned, in a two-by-two factorial design, to one of five ad libitum diets to prevent weight regain over a 26-week period: a low-protein and low-glycemic-index diet, a low-protein and high-glycemic-index diet, a high-protein and low-glycemic-index diet, a high-protein and high-glycemic-index diet, or a control diet. RESULTS: A total of 1209 adults were screened (mean age, 41 years; body-mass index [the weight in kilograms divided by the square of the height in meters], 34), of whom 938 entered the low-calorie-diet phase of the study. A total of 773 participants who completed that phase were randomly assigned to one of the five maintenance diets; 548 completed the intervention (71%). Fewer participants in the high-protein and the low-glycemic-index groups than in the low-protein-high-glycemic-index group dropped out of the study (26.4% and 25.6%, respectively, vs. 37.4%; P=0.02 and P=0.01 for the respective comparisons). The mean initial weight loss with the low-calorie diet was 11.0 kg. In the analysis of participants who completed the study, only the low-protein-high-glycemic-index diet was associated with subsequent significant weight regain (1.67 kg; 95% confidence interval [CI], 0.48 to 2.87). In an intention-to-treat analysis, the weight regain was 0.93 kg less (95% CI, 0.31 to 1.55) in the groups assigned to a high-protein diet than in those assigned to a low-protein diet (P=0.003) and 0.95 kg less (95% CI, 0.33 to 1.57) in the groups assigned to a low-glycemic-index diet than in those assigned to a high-glycemic-index diet (P=0.003). The analysis involving participants who completed the intervention produced similar results. The groups did not differ significantly with respect to diet-related adverse events. CONCLUSIONS: In this large European study, a modest increase in protein content and a modest reduction in the glycemic index led to an improvement in study completion and maintenance of weight loss

Atmospheric trace gases support primary production in Antarctic desert surface soil

LetterCultivation-independent surveys have shown that the desert soils of Antarctica harbour surprisingly rich microbial communities¹⁻³. Given that phototroph abundance varies across these Antarctic soils²·⁴, an enduring question is what supports life in those communities with low photosynthetic capacity³·⁵. Here we provide evidence that atmospheric trace gases are the primary energy sources of two Antarctic surface soil communities. We reconstructed 23 draft genomes from metagenomic reads, including genomes from the candidate bacterial phyla WPS-2 and AD3. The dominant community members encoded and expressed high-affinity hydrogenases, carbon monoxide dehydrogenases, and a RuBisCO lineage known to support chemosynthetic carbon fixation⁶·⁷. Soil microcosms aerobically scavenged atmospheric H₂ and CO at rates sufficient to sustain their theoretical maintenance energy and mediated substantial levels of chemosynthetic but not photosynthetic CO₂ fixation. We propose that atmospheric H₂, CO₂ and CO provide dependable sources of energy and carbon to support these communities, which suggests that atmospheric energy sources can provide an alternative basis for ecosystem function to solar or geological energy sources⁸·⁹. Although more extensive sampling is required to verify whether this process is widespread in terrestrial Antarctica and other oligotrophic habitats, our results provide new understanding of the minimal nutritional requirements for life and open the possibility that atmospheric gases support life on other planets.Mukan Ji, Chris Greening, Inka Vanwonterghem, Carlo R. Carere, Sean K. Bay, Jason A. Steen, Kate Montgomery, Thomas Lines, John Beardall, Josie van Dorst, Ian Snape, Matthew B. Stott, Philip Hugenholtz & Belinda C. Ferrar

Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing

Population-based estimates of breast cancer risk for carriers of pathogenic variants identified by gene-panel testing are urgently required. Most prior research has been based on women selected for high-risk features and more data is needed to make inference about breast cancer risk for women unselected for family history, an important consideration of population screening. We tested 1464 women diagnosed with breast cancer and 862 age-matched controls participating in the Australian Breast Cancer Family Study (ABCFS), and 6549 healthy, older Australian women enroled in the ASPirin in Reducing Events in the Elderly (ASPREE) study for rare germline variants using a 24-gene-panel. Odds ratios (ORs) were estimated using unconditional logistic regression adjusted for age and other potential confounders. We identified pathogenic variants in 11.1% of the ABCFS cases, 3.7% of the ABCFS controls and 2.2% of the ASPREE (control) participants. The estimated breast cancer OR [95% confidence interval] was 5.3 [2.1-16.2] for BRCA1, 4.0 [1.9-9.1] for BRCA2, 3.4 [1.4-8.4] for ATM and 4.3 [1.0-17.0] for PALB2. Our findings provide a population-based perspective to gene-panel testing for breast cancer predisposition and opportunities to improve predictors for identifying women who carry pathogenic variants in breast cancer predisposition genes.Melissa C. Southey, James G. Dowty, Moeen Riaz, Jason A. Steen, Anne-Laure Renault, Katherine Tucker ... et al