Influence of Eragrostis lehmanniana introduction on the grass community in the Ñacuñán Reserve (Mendoza, Argentina)

En 1976 se sembró E. lehmanniana Nees en la Reserva de Ñacuñán. Se evaluaron, después de 24 años de la siembra, la tasa lineal de dispersión, la abundancia y el impacto de esta especie exótica sobre la comunidad de gramíneas perennes nativas. Se compararon sitios dominados por la especie exótica con otros que incluían sólo vegetación nativa. Para comparar la cobertura de la canopia de las gramíneas, la cantidad de especies por parcela y la abundancia de la especie exótica se usó la prueba de Mann- Whitney. La especie exótica se dispersó 32 m año-1. Ella estaba presente en los caminos internos de la Reserva donde la vegetación nativa leñosa había sido eliminada y en el 45 % de los sitios ubicados en áreas no disturbadas adyacentes a los caminos. La cobertura total de las gramíneas nativas se redujo significativamente en los sitios donde la especie exótica estaba presente. La cantidad total de gramíneas por parcela no fue afectada por la presencia de E. lehmanniana. Pappophprum caespitosum, la gramínea dominante en Ñacuñán, y Sporobolus cryptandrus presentaron cobertura más baja en los sitios dominados por la especie exótica que en aquéllos no disturbados. La introducción de E. lehmanniana tuvo un impacto negativo en la composición de la comunidad de gramíneas perennes nativas en los sitios disturbados de la Reserva.E. lehmanniana Nees was seeded in Ñacuñán Reserve in 1976. The linear rate of spread, the abundance of this exotic grass and the impact of its introduction on the native perennial grass community were evaluated after 24 years seeding. Sites dominated by the exotic grass and those including only native vegetation were compared. The Mann- Whitney test was applied to compare grass canopy cover, number of species per plot and abundance of the exotic grass between the mentioned sites. The exotic grass spread 32 m year-1. It was present in tracks where the native woody vegetation had been removed, and in 45 % of the sites located in undisturbed areas adjacent to tracks. The total native grass canopy cover was significantly reduced in the sites where lovegrass was present. The number of total grass species per plot was not affected by the presence of the exotic grass. Pappophprum caespitosum, the dominant grass in Ñacuñán, and Sporobolus cryptandrus presented lower canopy cover in the sites dominated by the exotic species than that in the undisturbed ones. The introduction of E. lehmanniana has had a negative impact on the composition of the native perennial grass community in the disturbed sites of the Reserve.Fil: Guevara, Juan Carlos. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Departamento de Ciencias Económico-Jurídico y SocialesFil: Estevez, Oscar R..Fil: Stasi, Carlos R.

Histomorphometrical Evaluation of Myocyte Types in the Lamb

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Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management.

Idiopathic thrombocytopenic purpura (ITP) is characterized by a low platelet count, which is the result of both increased pla- telet destruction and insufficient platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modu- lation have been identified. Conventional treatments for ITP aim at reducing platelet destruction, either by immunosuppression or splenectomy. Two new thrombopoietic agents,AMG 531 and eltrombopag, have been used in clinical trials to stimulate platelet production in ITP patients not responsive to standard treatments. These new molecules bear no structural resemblance to thrombopoietin, but still bind and activate the thrombopoietin receptor. This review will focus on the pathophysiology and treatment of ITP in adults, highlighting recent advances in both fields

Skeletal myocyte types and vascularity in the Black Sicilian Pig.

The objective of this study was to verify the presence of giant fibres in the Black Sicilian pig skeletal muscle and to evaluate the effect of sex on histochemical and morphometric characteristics of the myocytes (myofibres) as well as vascularity of the muscle. Twenty Black Sicilian pigs (10 males, 10 females) from a farm in Sicily (Italy) were slaughtered at two years of age. Muscle tissues were obtained from three muscles: psoas major, longissimus dorsi, and trapezius. Myofibres were stained for myosin ATPase, succinic dehydrogenase, and α-amylase-PAS. For all fibre types, area and perimeter were measured. Slow-twitch oxidative fibres, fast-twitch glycolytic fibres and fast-twitch oxidative-glycolytic fibres were histochemically differentiated; an image-analyzing system was used. The results showed no differences between males and females in percentage of the fibre types, but there were significant differences between sexes in size of all the three fibre types. Psoas major muscle had a high percentage of slow-twitch oxidative fibres and contained more capillaries per fibre and per mm2 than trapezius and longissimus dorsi, in which fast-twitch glycolytic fibres dominated. The cross-sectional area of all fibres types was larger in longissimus dorsi than in trapezius and psoas major muscles; the giant fibres were absent in all the muscles studied. Fibre type composition may contribute to the variation of meat quality

Integration of 3G connectivity in planetlab Europe :A step of an evolutionary path towards heterogeneous large scale network testbeds

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Inflammaging and Complement System: A Link Between Acute Kidney Injury and Chronic Graft Damage

The aberrant activation of complement system in several kidney diseases suggests that this pillar of innate immunity has a critical role in the pathophysiology of renal damage of different etiologies. A growing body of experimental evidence indicates that complement activation contributes to the pathogenesis of acute kidney injury (AKI) such as delayed graft function (DGF) in transplant patients. AKI is characterized by the rapid loss of the kidney’s excretory function and is a complex syndrome currently lacking a specific medical treatment to arrest or attenuate progression in chronic kidney disease (CKD). Recent evidence suggests that independently from the initial trigger (i.e., sepsis or ischemia/reperfusions injury), an episode of AKI is strongly associated with an increased risk of subsequent CKD. The AKI-to-CKD transition may involve a wide range of mechanisms including scar-forming myofibroblasts generated from different sources, microvascular rarefaction, mitochondrial dysfunction, or cell cycle arrest by the involvement of epigenetic, gene, and protein alterations leading to common final signaling pathways [i.e., transforming growth factor beta (TGF-β), p16ink4a, Wnt/β-catenin pathway] involved in renal aging. Research in recent years has revealed that several stressors or complications such as rejection after renal transplantation can lead to accelerated renal aging with detrimental effects with the establishment of chronic proinflammatory cellular phenotypes within the kidney. Despite a greater understanding of these mechanisms, the role of complement system in the context of the AKI-to-CKD transition and renal inflammaging is still poorly explored. The purpose of this review is to summarize recent findings describing the role of complement in AKI-to-CKD transition. We will also address how and when complement inhibitors might be used to prevent AKI and CKD progression, therefore improving graft function

A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific doublemodification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes

Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: a prospective randomized study.

PURPOSE: In laboratory studies electromotive mitomycin C (MMC) demonstrated markedly increased transport rates compared with passive transport. We performed a prospective study in patients with high risk superficial bladder cancer to assess the efficacy of intravesical electromotive vs passive MMC using bacillus Calmette-Guerin (BCG) as a comparative treatment. MATERIALS AND METHODS: Following transurethral resection and multiple biopsies 108 patients with multifocal Tis, including 98 with T1 tumors, were randomized into 3 equal groups of 36 each who underwent 40 mg electromotive MMC instillation with 20 mA electric current for 30 minutes, 40 mg passive MMC with a dwell time of 60 minutes or 81 mg BCG with a dwell time of 120 minutes. Patients were scheduled for an initial 6 weekly treatments, a further 6 weekly treatments for nonresponders and a followup 10 monthly treatments for responders. Primary end points were the complete response rate at 3 and 6 months. MMC pharmacokinetics were assessed. RESULTS: The complete response for electromotive vs passive MMC at 3 and 6 months was 53% versus 28% (p = 0.036) and 58% versus 31% (p = 0.012). For BCG the responses were 56% and 64%. Median time to recurrence was 35 vs 19.5 months (p = 0.013) and for BCG it was 26 months. Peak plasma MMC was significantly higher following electromotive MMC than after MMC (43 vs 8 ng/ml), consistent with bladder content absorption. CONCLUSIONS: Intravesical electromotive administration increases bladder uptake of MMC, resulting in an improved response rate in cases of high risk superficial bladder cancer