91 research outputs found
COMPARATIVE CHARACTERIZATION OF THE MACROORGANISM IMMUNE RESPONSE AFTER PERORAL AND PARENTERAL INTRODUCTION OF METALLIC NANOCOMPOSITE
Influence of a cobalt-containing nanobiocomposite on basis of arabinogalactane on morphological changes in immunocompetent organs of the experimental animals at peroral and parenteral introduction was studied, by a computer program. Β«MorphometryΒ». Comparative estimation, of morphological and. histological changes in spleen and. regional lymph, nodes of the outbred. white mice was performed
Patient's relationship with medical staff: ethical, normative and communicative aspects
The aim of the study - to research the problem of interpreting the term βmedical mistakeβ by a bioethical and legal point of viewΠ¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ β ΠΏΠΎΠΊΠ°Π·Π°ΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠΎΠ±Π»ΡΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ°Π²ΠΈΠ» ΠΈ Π½ΠΎΡΠΌ ΠΎΠ±ΡΠ΅Π½ΠΈΡ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΠΌ ΡΠ°Π±ΠΎΡΠ½ΠΈΠΊΠΎΠΌ, Π½ΠΎ ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌΠΈ
ESTIMATION OF INFLUENCE OF ARGENTOGALACTOMANNAN AND ARGENTO-POLY-1-VINYL-1,2,4-TRIAZOLE ON POPULATION STRUCTURE OF RED MARROW CELLS OF EXPERIMENTAL ANIMALS
We studied influence of silver-containing nanocomposites β galactomannan and poly-1-vinyl-1,2,4-triazole β on cell structure of peripheral blood and red marrow of white mice. The results obtained after the experiments testify that these nanocomposites aren't toxic, the changes caused by their introduction are productive and. part of them points at the activization of immune system of macroorganizm
Π‘ΠΏΠ΅ΠΊΡΡ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ³ΡΠΈΠ±ΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΡΡΠ»Π°Π½
ΠΡΠΎΠ±Π»Π΅ΠΌΠ°ΡΠΈΠΊΠ°. ΠΠ΅ΡΡΠ° ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Π° XXΠ ΡΡ. Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ²Π°Π»Π°ΡΡ ΠΏΠΎΠΌΡΡΠ½ΠΈΠΌ Π·ΡΠΎΡΡΠ°Π½Π½ΡΠΌ Π·Π°Ρ
Π²ΠΎΡΡΠ²Π°Π½ΠΎΡΡΡ Π½Π° ΠΌΡΠΊΠΎΠ·ΠΈ. ΠΠ½Π°ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠΈΡΠΎΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΡΠΈΡΠ΅Π½Π½Ρ Π½Π°Π±ΡΠ»Π° Π½ΠΈΠ·ΠΊΠ° Π³ΡΠΈΠ±ΠΊΠΎΠ²ΠΈΡ
ΡΠ½ΡΠ΅ΠΊΡΡΠΉ, Π·ΠΎΠΊΡΠ΅ΠΌΠ° Π΄Π΅ΡΠΌΠ°ΡΠΎΡΡΡΡΠΉ ΡΠ° Π²Π°Π³ΡΠ½Π°Π»ΡΠ½ΠΈΠΉ ΠΊΠ°Π½Π΄ΠΈΠ΄ΠΎΠ· (ΠΌΠΎΠ»ΠΎΡΠ½ΠΈΡΡ), ΡΠΎ ΠΌΠΎΠΆΠ½Π° ΠΏΠΎΡΡΠ½ΠΈΡΠΈ ΡΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡ ΠΌΡΠ³ΡΠ°ΡΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½Π½Ρ ΡΠ° Π·ΠΌΡΠ½ΠΎΡ ΡΠΏΠΎΡΠΎΠ±Ρ ΠΆΠΈΡΡΡ Π² ΡΠ½Π΄ΡΡΡΡΡΠ°Π»ΡΠ½ΠΈΡ
ΠΊΡΠ°ΡΠ½Π°Ρ
. Π¦Π΅ Π·ΡΠΎΡΡΠ°Π½Π½Ρ Π½Π΅ Π²Π΄Π°Π»ΠΎΡΡ Π·ΡΠΏΠΈΠ½ΠΈΡΠΈ Ρ ΠΏΡΡΠ»Ρ Π²ΠΏΡΠΎΠ²Π°Π΄ΠΆΠ΅Π½Π½Ρ Π½ΠΎΠ²ΡΡΠ½ΡΡ
Π°Π½ΡΠΈΠΌΡΠΊΠΎΡΠΈΡΠ½ΠΈΡ
Π·Π°ΡΠΎΠ±ΡΠ², Π±ΡΠ»ΡΡΡΡΡΡ ΡΠ· ΡΠΊΠΈΡ
ΠΌΠ°ΡΡΡ ΠΏΠΎΠ±ΡΡΠ½Ρ Π΄ΡΡ ΡΠ° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡΡ Π·Π½Π°ΡΠ½ΠΎΡ ΡΠΎΠΊΡΠΈΡΠ½ΡΡΡΡ. Π£ Π·Π²βΡΠ·ΠΊΡ Π· ΡΠΈΠΌ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΈΠΌ Π·Π°Π»ΠΈΡΠ°ΡΡΡΡΡ ΡΠΎΠ·ΡΠΎΠ±Π»Π΅Π½Π½Ρ Π½ΠΎΠ²ΠΈΡ
Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΠΈΡ
Ρ Π½Π΅ΡΠΎΠΊΡΠΈΡΠ½ΠΈΡ
ΠΏΡΠΈΡΠΎΠ΄Π½ΠΈΡ
Π°Π½ΡΠΈΠΌΡΠΊΠΎΡΠΈΠΊΡΠ². ΠΠ΅ΡΠ° Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π΄Π΅ΡΠΊΠΈΡ
ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΡ
ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΡΠ² Π΄ΡΡ Π²ΡΡΡΠΈΠ·Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΌΡΠΊΠΎΡΠΈΠΊΠ° ΠΡΡΠ»Π°Π½, Π° ΡΠ°ΠΌΠ΅ ΡΠΏΠ΅ΠΊΡΡΠ° Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π²ΡΠ΄Π½ΠΎΡΠ½ΠΎ Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
, Π³ΡΠ°ΠΌΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΡΠΉ, ΠΌΡΠΊΡΠΎΡΠΊΠΎΠΏΡΡΠ½ΠΈΡ
Π³ΡΠΈΠ±ΡΠ² ΡΠ° Π΄ΡΡΠΆΠ΄ΠΆΡΠ²; Π²ΠΏΠ»ΠΈΠ² Π½Π° ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½Ρ ΠΎΠ·Π½Π°ΠΊΠΈ ΡΠ° ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π΄ΡΡΠΆΠ΄ΠΆΡΠ². ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΡΠ΅Π°Π»ΡΠ·Π°ΡΡΡ. ΠΠΈΠ²ΡΠ΅Π½Π½Ρ Π°Π½ΡΠΈΠΌΡΠΊΡΠΎΠ±Π½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΡΡΠΉΠ½ΠΈΡ
ΡΠΎΠ·Π²Π΅Π΄Π΅Π½Ρ. ΠΠΈΠ²ΡΠ΅Π½Π½Ρ Π΄ΠΈΠ½Π°ΠΌΡΠΊΠΈ Π·Π°Π³ΠΈΠ±Π΅Π»Ρ ΠΊΠ»ΡΡΠΈΠ½ ΠΏΡΠ΄ Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ ΠΡΡΠ»Π°Π½Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»Ρ ΠΊΡΠ»ΡΡΡΡΠΈ Candida tropicalis. ΠΠΌΡΠ½ΠΈ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡ ΠΊΠ»ΡΡΠΈΠ½ Π²ΠΈΠ²ΡΠ°Π»ΠΈ Π·Π° Π΄ΠΎΠΏΠΎΠΌΠΎΠ³ΠΎΡ ΡΠ²ΡΡΠ»ΠΎΠ²ΠΎΠ³ΠΎ ΠΌΡΠΊΡΠΎΡΠΊΠΎΠΏΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΈ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ ΠΡΡΠ»Π°Π½ Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π΄ΡΡ, Π°ΠΊΡΠΈΠ²Π½ΠΈΠΌ ΠΏΡΠΎΡΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
ΡΠ° Π³ΡΠ°ΠΌΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΡΠΉ, Π΄ΡΡΠΆΠ΄ΠΆΡΠ² ΡΠ° ΠΏΠ»ΡΡΠ½ΡΠ²ΠΈΡ
Π³ΡΠΈΠ±ΡΠ². ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΌΡΠ½ΡΠΌΠ°Π»ΡΠ½Ρ ΠΏΡΠΈΠ³Π½ΡΡΡΠ²Π°Π»ΡΠ½Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ Π²ΡΠ΄Π½ΠΎΡΠ½ΠΎ Π΄ΡΡΠΆΠ΄ΠΆΡΠ² (250-500 ΠΌΠΊΠ³/ΠΌΠ»), Π³ΡΠΈΠ±ΡΠ² (62,5-500 ΠΌΠΊΠ³/ΠΌΠ»), Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
(31,2-250 ΠΌΠΊΠ³/ΠΌΠ») ΡΠ° Π³ΡΠ°ΠΌΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΈΡ
(62,5-250 ΠΌΠΊΠ³/ΠΌΠ») Π±Π°ΠΊΡΠ΅ΡΡΠΉ. ΠΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΡΡΠ½ΠΈΡ
ΠΎΠ·Π½Π°ΠΊ ΠΊΠ»ΡΡΠΈΠ½ Candida tropicalis ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΠΎ Π²Π½Π΅ΡΠ΅Π½Π½Ρ ΠΡΡΠ»Π°Π½Ρ Π² ΠΆΠΈΠ²ΠΈΠ»ΡΠ½Π΅ ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΠ΅ Ρ ΡΡΠ½Π³ΡΡΠΈΠ΄Π½ΡΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ ΠΏΡΠΈΠ·Π²ΠΎΠ΄ΠΈΠ»ΠΎ Π΄ΠΎ Π·ΠΌΡΠ½ΠΈ ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Ρ ΠΊΠ»ΡΡΠΈΠ½ Π΄ΡΡΠΆΠ΄ΠΆΡΠ², ΡΡΡΠΏΡΠ½Ρ ΠΏΡΠΎΡΠ²Ρ ΡΠΊΠΎΠ³ΠΎ Π±ΡΠ»Π° ΠΎΠ±ΡΠΌΠΎΠ²Π»Π΅Π½Π° ΡΠ°ΡΠΎΠ²ΠΈΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ. ΠΠΎΡΠ²Π° ΠΏΡΠ΄ Π²ΠΏΠ»ΠΈΠ²ΠΎΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΡ ΠΎΠΏΡΠΊΠ»ΠΎΡΡΠ΅ΠΉ ΡΠ° ΡΠΎΠ·ΡΠΈΠ²ΡΠ² Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½Ρ ΠΊΠ»ΡΡΠΈΠ½ Π΄ΡΡΠΆΠ΄ΠΆΡΠ², Π° ΡΠ°ΠΊΠΎΠΆ Π·ΠΌΡΠ½Π° ΡΡ
ΡΠΎΡΠΌΠΈ, Π²ΡΡΠΎΠ³ΡΠ΄Π½ΠΎ, Π±ΡΠ»ΠΈ Π½Π°ΡΠ»ΡΠ΄ΠΊΠΎΠΌ ΠΏΠΎΡΡΡΠ΅Π½Π½Ρ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΡΠ½Ρ ΡΠ΅ΡΠΎΠ²ΠΈΠ½ ΠΊΡΠ»ΡΡΡΡΠΈ, ΡΠΎ ΠΏΡΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΎΡΡ Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΠΌΠΈ Π΄Π°Π½ΠΈΠΌΠΈ. ΠΠΈΡΠ½ΠΎΠ²ΠΊΠΈ. ΠΡΡΠΈΠΌΠ°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ ΡΠ²ΡΠ΄ΡΠ°ΡΡ, ΡΠΎ ΠΡΡΠ»Π°Π½ Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π΄ΡΡ, Π°ΠΊΡΠΈΠ²Π½ΠΈΠΌ Π½Π΅ Π»ΠΈΡΠ΅ Π²ΡΠ΄Π½ΠΎΡΠ½ΠΎ ΠΌΡΠΊΡΠΎΠΌΡΡΠ΅ΡΡΠ² ΡΠ° Π΄ΡΡΠΆΠ΄ΠΆΠΎΠ²ΠΈΡ
ΠΊΡΠ»ΡΡΡΡ, Π°Π»Π΅ ΠΉ Π²ΡΠ΄Π½ΠΎΡΠ½ΠΎ Π³ΡΠ°ΠΌΠΏΠΎΠ·ΠΈΡΠΈΠ²Π½ΠΈΡ
Ρ Π³ΡΠ°ΠΌΠ½Π΅Π³Π°ΡΠΈΠ²Π½ΠΈΡ
Π±Π°ΠΊΡΠ΅ΡΡΠΉ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΠΎ ΠΡΡΠ»Π°Π½Π²ΠΏΠ»ΠΈΠ²Π°Ρ Π½Π° ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΡΡΠ½Ρ ΠΏΡΠΎΡΠ΅ΡΠΈ Π³ΡΠΈΠ±ΠΊΠΎΠ²ΠΎΡ ΠΊΠ»ΡΡΠΈΠ½ΠΈ.Background. The first half of the XXI-st century is characterized by increasing in the incidence of fungal infections. A wide range of spatial spreading of fungal infections, including dermatophytes and vaginal candidiasis (thrush), which can be explained by intensive migration and changing lifestyles in industrialized countries. This growth was not stopped after the introduction of new antifungal pharmaceuticals, most of which have side effects and are characterized by significant toxicity. In this regard, remains perspective development of new effective non-toxic natural antifungal drugs. Objective. The study of some potential mechanisms of domestic antimycotic Esulanum such as spectrum antimicrobial activity against gram-positive, gram-negative bacteria, microscopic fungi and yeast; influence on morphological characteristics and enzymatic activity of yeast. Methods. The study of antimicrobial activities was performed by preparation of serial dilutions. Study of the dynamics of cell death under the influence of Esulanum performed on models of culture Candida tropicalis. Cell morphology was studied using a light microscope. Results. It was shown that the Esulanum has a broad-spectrum activity against gram-positive and gram-negative bacteria, yeasts and fungies. Minimum inhibitory concentration of Esulanum against yeast (250-500 ug/ml), fungi (62,5-500 ug/ml) gram-positive (31,2-250 ug/ml) and gram-negative (62,5-250 ug/ml) bacteria was established. The study of morphological character of Candida tropicalis cells showed that the introduction of Esulanum into the culture medium in the fungicidal concentration led to changes in the morphogenesis of yeast cells, the degree of manifestation of which was due to a temporary agent. The appearance under the influence of the drug bumps and disruptions on the surface of yeast cells, as well as change their shape was probably due to a breach of the normal metabolism of culture, which was confirmed by the experimental data. Conclusions. The results indicate that Esulanum is a broad-spectrum drug, active not only in relation to micromycetes and yeast cultures, but also Gram-positive and Gram-negative bacteria. It was found that Esulanum affects the metabolic processes of the fungal cells. During the preclinical studies further research should be aimed at the study of the mechanism of action of the drug on cells of fungal cultures.ΠΡΠΎΠ±Π»Π΅ΠΌΠ°ΡΠΈΠΊΠ°. ΠΠ΅ΡΠ²Π°Ρ ΠΏΠΎΠ»ΠΎΠ²ΠΈΠ½Π° XXI Π²Π΅ΠΊΠ° Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΠΎΠ²Π°Π»Π°ΡΡ Π·Π°ΠΌΠ΅ΡΠ½ΡΠΌ ΡΠΎΡΡΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π΅ΠΌΠΎΡΡΠΈ ΠΌΠΈΠΊΠΎΠ·Π°ΠΌΠΈ. Π¨ΠΈΡΠΎΠΊΠΎΠ΅ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ΅ ΡΠ°ΡΠΏΡΠΎΡΡΡΠ°Π½Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ»ΡΡΠΈΠ» ΡΡΠ΄ Π³ΡΠΈΠ±ΠΊΠΎΠ²ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Π΄Π΅ΡΠΌΠ°ΡΠΎΡΠΈΡΠΈΠΉ ΠΈ Π²Π°Π³ΠΈΠ½Π°Π»ΡΠ½ΡΠΉ ΠΊΠ°Π½Π΄ΠΈΠ΄ΠΎΠ· (ΠΌΠΎΠ»ΠΎΡΠ½ΠΈΡΠ°), ΡΡΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΠΎΠ±ΡΡΡΠ½ΠΈΡΡ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΠΉ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠ΅ΠΉ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·Π° ΠΆΠΈΠ·Π½ΠΈ Π² ΠΈΠ½Π΄ΡΡΡΡΠΈΠ°Π»ΡΠ½ΡΡ
ΡΡΡΠ°Π½Π°Ρ
. ΠΡΠΎΡ ΡΠΎΡΡ Π½Π΅ ΡΠ΄Π°Π»ΠΎΡΡ ΠΎΡΡΠ°Π½ΠΎΠ²ΠΈΡΡ ΠΈ ΠΏΠΎΡΠ»Π΅ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ Π½ΠΎΠ²Π΅ΠΉΡΠΈΡ
Π°Π½ΡΠΈΠΌΠΈΠΊΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ², Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²ΠΎ ΠΈΠ· ΠΊΠΎΡΠΎΡΡΡ
ΠΈΠΌΠ΅ΡΡ ΠΏΠΎΠ±ΠΎΡΠ½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠΎΠΊΡΠΈΡΠ½ΠΎΡΡΡΡ. Π ΡΠ²ΡΠ·ΠΈ Ρ ΡΡΠΈΠΌ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΎΡΡΠ°Π΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° Π½ΠΎΠ²ΡΡ
ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈ Π½Π΅ΡΠΎΠΊΡΠΈΡΠ½ΡΡ
ΠΏΡΠΈΡΠΎΠ΄Π½ΡΡ
Π°Π½ΡΠΈΠΌΠΈΠΊΠΎΡΠΈΠΊΠΎΠ². Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠΎΠ² Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΎΡΠ΅ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΈΠΌΠΈΠΊΠΎΡΠΈΠΊΠ° ΠΡΡΠ»Π°Π½Π°, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π² ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
, Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ, ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΡΠ΅ΡΠΊΠΈΡ
Π³ΡΠΈΠ±ΠΎΠ² ΠΈ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ; Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΈ ΠΈ ΡΠ΅ΡΠΌΠ΅Π½ΡΠ°ΡΠΈΠ²Π½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ. ΠΠ΅ΡΠΎΠ΄ΠΈΠΊΠ° ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ΅ΡΠΈΠΉΠ½ΡΡ
ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΠΉ. ΠΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠΈ Π³ΠΈΠ±Π΅Π»ΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΡΡΠ»Π°Π½Π° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΊΡΠ»ΡΡΡΡΡ Candida tropicalis. ΠΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π² ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈΠ·ΡΡΠ°Π»ΠΈ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠ²Π΅ΡΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΡΡΠ»Π°Π½ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, Π°ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΈ Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ, Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ ΠΈ ΠΏΠ»Π΅ΡΠ½Π΅Π²ΡΡ
Π³ΡΠΈΠ±ΠΎΠ². Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΠ΅ ΠΏΠΎΠ΄Π°Π²Π»ΡΡΡΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ (250-500 ΠΌΠΊΠ³/ΠΌΠ»), Π³ΡΠΈΠ±ΠΎΠ² (62,5-500 ΠΌΠΊΠ³/ΠΌΠ»), Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
(31,2-250 ΠΌΠΊΠ³/ΠΌΠ») ΠΈ Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
(62,5-250 ΠΌΠΊΠ³/ΠΌΠ») Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ² ΠΊΠ»Π΅ΡΠΎΠΊ Candida tropicalis ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ Π²Π½Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΡΡΠ»Π°Π½Π° Π² ΠΏΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ ΡΡΠ΅Π΄Ρ Π² ΡΡΠ½Π³ΠΈΡΠΈΠ΄Π½ΠΎΠΉ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΠ»ΠΎ ΠΊ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΌΠΎΡΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΊΠ»Π΅ΡΠΎΠΊ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ, ΡΡΠ΅ΠΏΠ΅Π½Ρ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ Π±ΡΠ»Π° ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π° Π²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΡΠ°ΠΊΡΠΎΡΠΎΠΌ. ΠΠΎΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΠ΄ Π²Π»ΠΈΡΠ½ΠΈΠ΅ΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π²ΡΠΏΡΠΊΠ»ΠΎΡΡΠ΅ΠΉ ΠΈ ΡΠ°Π·ΡΡΠ²ΠΎΠ² Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ Π΄ΡΠΎΠΆΠΆΠ΅ΠΉ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΡ
ΡΠΎΡΠΌΡ, Π²Π΅ΡΠΎΡΡΠ½ΠΎ, Π±ΡΠ»ΠΈ ΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠ΅ΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΠΌΠ΅Π½Π° Π²Π΅ΡΠ΅ΡΡΠ² ΠΊΡΠ»ΡΡΡΡΡ, ΡΡΠΎ ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ»ΠΎΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΠΌΠΈ Π΄Π°Π½Π½ΡΠΌΠΈ. ΠΡΠ²ΠΎΠ΄Ρ. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡ, ΡΡΠΎ ΠΡΡΠ»Π°Π½ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠΌ ΡΠΈΡΠΎΠΊΠΎΠ³ΠΎ ΡΠΏΠ΅ΠΊΡΡΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡ, Π°ΠΊΡΠΈΠ²Π½ΡΠΌ Π½Π΅ ΡΠΎΠ»ΡΠΊΠΎ ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΌΠΈΠΊΡΠΎΠΌΠΈΡΠ΅ΡΠ°ΠΌ ΠΈ Π΄ΡΠΎΠΆΠΆΠ΅Π²ΡΠΌ ΠΊΡΠ»ΡΡΡΡΠ°ΠΌ, Π½ΠΎ ΠΈ ΠΊ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠΌ ΠΈ Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΠΌ Π±Π°ΠΊΡΠ΅ΡΠΈΡΠΌ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΡΡΠ»Π°Π½ Π²Π»ΠΈΡΠ΅Ρ Π½Π° ΠΌΠ΅ΡΠ°Π±ΠΎΠ»ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΡ Π³ΡΠΈΠ±Π½ΠΎΠΉ ΠΊΠ»Π΅ΡΠΊΠΈ. ΠΡΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π΄ΠΎΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ°Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠ°Ρ ΡΠ°Π±ΠΎΡΠ° Π΄ΠΎΠ»ΠΆΠ½Π° Π±ΡΡΡ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π° Π½Π° ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ° Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½Π° ΠΊΠ»Π΅ΡΠΊΠΈ Π³ΡΠΈΠ±Π½ΡΡ
ΠΊΡΠ»ΡΡΡΡ
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΌΠΈΠΊΠΎΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΈ ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·Π΅ Ρ Π΄Π΅ΡΠ΅ΠΉ
Fifty-two children with cystic fibrosis (CF) were examined. An association between risk factors for mycosis and mycoallergosis occurrence in CF children was found. Clinical features of this patology were reviewed. A relation between systemic mycosis prevalence and CF severity was shown. Diagnosis criteria and management of mycotic infections and allergic complications in CF were developed.ΠΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Ρ 52 ΡΠ΅Π±Π΅Π½ΠΊΠ° Ρ ΠΌΡΠΊΠΎΠ²ΠΈΡΡΠΈΠ΄ΠΎΠ·ΠΎΠΌ (M B). Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Π° Π°ΡΡΠΎΡΠΈΠ°ΡΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ° ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΈΠΊΠΎΠ·ΠΎΠ² ΠΈ ΠΌΠΈΠΊΠΎΠ°Π»Π»Π΅ΡΠ³ΠΎΠ·ΠΎΠ² ΠΏΡΠΈ M B Ρ Π΄Π΅ΡΠ΅ΠΉ. ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΡΠΎΠΉ ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΈ. ΠΡΡΠ²Π»Π΅Π½Π° Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΡΠ°ΡΡΠΎΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΡΡ
ΡΠΎΡΠΌ ΠΌΠΈΠΊΠΎΠ·ΠΎΠ² ΠΎΡ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠΆΠ΅ΡΡΠΈ MB. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΡΠ°ΠΊΡΠΈΠΊΠ° Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΈ Π°Π»Π»Π΅ΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ ΠΏΡΠΈ MB
COMPARATIVE CHARACTERISTICS OF IMMUNOLOGICAL RECONSTRUCTION OF WHITE MICE IMMUNIZED BY CELL WALL OF DIFFERENT SUBSPECIES OF FRANCISELLA TULARENSIS
At present, development of effective vaccines of new generation is an actual problem, in particular concerning the tularemia causative agent. It determines the need to search antigen determinants with high immunogenic activity. Some authors demonstrate that outer membrane proteins of Francisella tularensis possess immunological activity. This fact gave occasion to isolation and comprehensive study of F tularensis cellular envelopes as a perspective component in vaccine engineering. The influence of cell walls of F. tularensis was studied for morphological changes in immunocompetent organs of experimental animals. Cell walls were obtained from three virulence strains of living cultures: F. tularensis subsp. mediaasiatica Π-61, F. tularensis subsp. nearctica Π-399 A-Cole, F. tularensis subsp. holarctica 306 and vaccine strain F. tularensis subsp. holarctica 15 (extracted by Research Institute of Epidemiology and Hygiene). Cell walls of different subspecies of F. tularensis stimulate the production of antibody forming cells and cell proliferation more in T-dependent zones of lymph nodes and spleen. It has been determined that these antigen preparations do not cause stress reaction of the experimental animal organisms. Basing on the findings, we made a conclusion that there is a need for further detailed investigation of immunogenic properties of CE F. tularensis subsp. holarctica 306, F. tularensis subsp. mediasiatica Π-61 and F. tularensis subsp. tularensis B-399 A-Cole as perspective components in development of tularemia vaccines
ΠΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½Π°Ρ ΡΠ΅ΡΠ°ΠΏΠΈΡ ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Ρ Π±ΠΎΠ»ΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΡΠΊΠ»Π΅ΡΠΎΠ΄Π΅ΡΠΌΠΈΠ΅ΠΉ
Scleroderma systematica (SDS) is a disease in which vascular diseases underlie the pathogenesis and presented by diverse clinical manifestations. Raynaud's syndrome and digital ulceration are the most common symptom of the diseases, which influences the quality of life in patients and requires continuous drug therapy. The paper discusses the recent European guidelines for the management of this manifestation of SDS. The proposed recommendations cannot unfortunately be realized in full measure now due to the unavailability of some drugs. The authors give their clinical experience with therapy for the vascular manifestations of SDS.Π‘ΠΈΡΡΠ΅ΠΌΠ½Π°Ρ ΡΠΊΠ»Π΅ΡΠΎΠ΄Π΅ΡΠΌΠΈΡ (Π‘Π‘Π) - Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠ΅, ΠΏΡΠΈ ΠΊΠΎΡΠΎΡΠΎΠΌ ΡΠΎΡΡΠ΄ΠΈΡΡΡΠ΅ Π½Π°ΡΡΡΠ΅Π½ΠΈΡ Π»Π΅ΠΆΠ°Ρ Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π° ΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡΠΌΠΈ. Π‘ΠΈΠ½Π΄ΡΠΎΠΌ Π Π΅ΠΉΠ½ΠΎ ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠ³ΠΈΡΠ°Π»ΡΠ½ΡΡ
ΡΠ·Π² - Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠ°ΡΡΡΠΉ ΡΠΈΠΌΠΏΡΠΎΠΌ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π²Π»ΠΈΡΡΡΠΈΠΉ Π½Π° ΠΊΠ°ΡΠ΅ΡΡΠ²ΠΎ ΠΆΠΈΠ·Π½ΠΈ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² ΠΈ ΡΡΠ΅Π±ΡΡΡΠΈΠΉ ΠΏΠΎΡΡΠΎΡΠ½Π½ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ. Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ Π½Π΅Π΄Π°Π²Π½ΠΎ ΠΎΠΏΡΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΡΠ΅ Π΅Π²ΡΠΎΠΏΠ΅ΠΉΡΠΊΠΈΠ΅ ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΈ ΠΏΠΎ Π»Π΅ΡΠ΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΡ Π‘Π‘Π. ΠΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π½ΡΡ
ΡΠ΅ΠΊΠΎΠΌΠ΅Π½Π΄Π°ΡΠΈΠΉ Π² ΠΏΠΎΠ»Π½ΠΎΠΌ ΠΎΠ±ΡΠ΅ΠΌΠ΅, ΠΊ ΡΠΎΠΆΠ°Π»Π΅Π½ΠΈΡ, Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π΅Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎ ΠΈΠ·-Π·Π° Π½Π΅Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΠΈ Π½Π΅ΠΊΠΎΡΠΎΡΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ². ΠΠ²ΡΠΎΡΠ°ΠΌΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡΡΡ ΡΠΎΠ±ΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠΏΡΡ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ Π‘Π‘Π
INFLUENCE OF BRUCELLA ABORTUS I-206 THERMOEXTRACTS IN L- AND S-FORM ON MORPHOFUNCTIONAL STATE OF WHITE MICE ADRENAL GLANDS
Live vaccines are used for specific brucellosis prophylaxis in the Russian Federation. These vaccines in addition toΒ a number ofΒ positive properties have some limitations including highΒ agglutinogenicity, reactogenicity, sensitizingΒ activity. In thisΒ connection, the development of subunit vaccines without adverseΒ reactions is a perspective directionΒ in modern vaccinology.Β ComplexΒ morphological research of the adrenal glands and comparativeΒ analysis of peripheral blood (leukogram, leukocyticΒ index and indexΒ of allergization) of white mice immunized with thermoextracts (Π’E)Β of Brucella abortus I-206 inΒ L- and S-form and inactivated vaccine B.Β abortus 19 ΠΠ were conducted. It was shown that Π’E unlike B.Β abortus 19 ΠΠΒ caused minor alterations in peripheral blood of theΒ experimental animals in early periods of observation (increase ofΒ allergization index, changes in leukogram) with the subsequentΒ levelling to the values in control.Β Expositions of the adrenal glandΒ zoning were determined and cellular structure was estimated inΒ consideration ofΒ morphometry. Changes in architectonics of the miceΒ organ immunized with B. abortus 19 ΠΠ were revealed. TheseΒ alterations could indicate the stress-reaction development. InΒ case of Π’E application the given changes were insignificantΒ and wereΒ developed in early periods.Β The revealed morphological changes inΒ adrenal glands of laboratory animals permit to prove the necessity ofΒ realizationΒ the further experimental researches to Π’E applicationΒ as the components for development of a subcellular brucellosisΒ vaccine
SCLERODERMA SYSTEMATICA WITH INTERSTITIAL LUNG LESION: COMPARATIVE CLINICAL CHARACTERISTICSWITH PATIENTS WITHOUT LUNG LESION
Objective. To compare disease history data and clinical and laboratory parameters in patients with scleroderma systematica (SDS) with high-resolution computed tomography (HRCT)-verified interstitial lung lesion (ILL) versus those without lung involvement. Subjects and methods. An examination was made in 138 patients with SDS who had been consecutively admitted in 2006-2008, female/male ratio, 124 : 14; limited : diffuse : mixed forms, 78 : 40 : 20; mean age, 47Β±13 years; median disease duration, 6 (2.5 11) years. The history data (occupational hazards, smoking, respiratory diseases) and clinical manifestations of SDS and laboratory data were studied. The diagnosis of ILL was established on the basis of chest HRCT. Results. According to HRCT data, the signs of varying ILL were found in 82% of the patients with SDS. The duration of SDS was similar in the patients with and without lung involvement; but the latter were younger at the time of disease onset. There were no significant differences between the groups compared in history data, clinical forms of SDS, the frequency of involvement of visceral organs and systems. Crepitation was heard only in the patients with ILL. The frequency of respiratory manifestations increased with a larger number of the involved lung segments. The prevalence of ILL was found to be positively correlated with age at the onset of SDS (r=0.29;
Radioisotope Products and the Medicine of the Future: an IAEA Perspective
The production and application of radioisotopes and radiopharmaceuticals is a major peaceful application of nuclear science and technology and has opened new gateways for nuclear medicine in critical human diseases. Advances in the production of radioisotopes via nuclear reactors, accelerators, fission, etc. has facilitated the access to these products for Member States. 99Mo, 131I, 177Lu are among the most essential radioisotopes for nuclear medicine and human health and their production and availability always has been an important theme for professional societies and the International Atomic Energy Agency (IAEA). In the meantime, a large list of theranostic radioisotopes including but not limited to 89Zr, 68Ga, 225Ac, Cu-series, Sc-series, Tb-series etc. has provided a powerful toolbox for clinicians and the IAEA is taking steps to ensure their safe and appropriate application in radiopharmacy. The Agency promotes the production and application routes, including research reactors, cyclotrons, linear accelerators, and other cutting-edge methods, according to international and national guidelines and regulations. The IAEA also conducts activities such as Coordinated Research Projects (CRPs), Technical Meetings (TMs), national/regional training courses and conferences, to support and join forces with international professional societies in the development of human resources and research and development activities. Development of databases and freely available publications for all Member States are other useful means to support Member States in radiopharmaceutical sciences
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