DEVELOPMENT OF MANAGEMENT OF REPRODUCTION OF FIXED ASSETS

The article is devoted to topical issues of development of management of reproduction of fixed assets. The authors emphasize an important role for the successful solution of important problems of development management of such forms of reproduction of fixed assets as the repair, reconstruction, modernization or upgrading in terms of implementation of innovation investment in the modern requirements of the domestic market economy

DEVELOPMENT OF MANAGEMENT OF REPRODUCTION OF FIXED ASSETS

The article is devoted to topical issues of development of management of reproduction of fixed assets. The authors emphasize an important role for the successful solution of important problems of development management of such forms of reproduction of fixed assets as the repair, reconstruction, modernization or upgrading in terms of implementation of innovation investment in the modern requirements of the domestic market economy

Actuality IT - consulting in conditions of the Russian economy

The purpose of it consulting is to provide recommendations on the strategic management of information systems, evaluation, design and development of it architecture, project management, automation of business processes of organizations, and many other issues related to using of computers and information technology. This paper describes typical tasks of consulting projects in the it sector, the structure of the Russian market of it services-consulting, action for development and regulation of the market of it-consulting in conditions of the Russian economyНазначение ИТ - консалтинга заключается в предоставлении рекомендаций по вопросам стратегического управления информационными системами, оценки, проектирования и разработки ИТ - архитектуры, управления проектами автоматизации бизнес-процессов организаций и многим другим вопросам, связанным с использованием вычислительной техники и информационных технологий. В данной работе описаны типовые задачи консалтинговых проектов в сфере ИТ, определена структура российского рынка услуг ИТ - консалтинга, меры по развитию и регулированию рынка ИТ - консалтинга в условиях российской экономик

A Drosophila DEG/ENaC Subunit Functions Specifically In Gustatory Neurons Required For Male Courtship Behavior

Detection of specific female pheromones stimulates courtship behavior in Drosophila melanogaster males, but the chemosensory molecules, cells, and mechanisms involved remain poorly understood. Here we show that ppk25, a DEG/ENaC ion channel subunit required for normal male response to females, is expressed at highest levels in a single sexually dimorphic gustatory neuron of most taste hairs on legs and wings, but not in neurons that detect courtship-inhibiting pheromones or food. Synaptic inactivation of ppk25-expressing neurons, or knockdown of ppk25 expression in all gustatory neurons, significantly impairs male response to females, whereas gustatory expression of ppk25 rescues the courtship behavior of ppk25 mutant males. Remarkably, the only other detectable albeit significantly weaker expression of ppk25 occurs in olfactory neurons implicated in modulation of courtship behavior. However, expression of ppk25 in olfactory neurons is not required for male courtship under our experimental conditions. These data show that ppk25 functions specifically in peripheral taste neurons involved in activation of courtship behavior, an unexpected function for this type of channel. Furthermore, our work identifies a small subset of gustatory neurons with an essential role in activation of male courtship behavior, most likely in response to female pheromones

Depression, cognitive dysfunction and other factors associated with 5-year overall mortality in type 2 diabetes mellitus: a pilot prospective observational study

BACKGROUND: Psychological predictors of overall mortality in the Russian population of Type 2 diabetic patients and their impact compared to biological risk factors have not been studied.AIM. To identify clinical, laboratory and psychological factors independently associated with the 5-year overall mortality in Type 2 diabetic patients in the Moscow region.MATERIALS AND METHODS: This open label observational prospective study included 178 consecutive type 2 diabetic patients (women 145, men 33, age range 37 to 82 years, duration of diabetes 0,5 to 30 years). At baseline, in addition to the standard clinical, laboratory and instrumental work-up, all patients were assessed for depression, cognitive dysfunction and diabetes-related quality of life. No study-related intervention was performed; all patients were followed up and treated by their local physicians. After 5 years, we assessed the patients’ vital status (alive or dead). Multiple logistic regression was used to identify baseline patients’ characteristics, which were significantly and independently associated with 5-year overall mortality. Taking into account the exploratory type of multiple regression, the results were considered significant at α<0.1.RESULTS: At 5 years, 150 (84%) patients were alive and 15 (8,4%) were dead; no information could be obtained for the rest 13 (7,3%) patients. The analysis of 165 patients with the verified outcome, independent and significant associations with the death outcome were found for male gender (odds ratio [OR] 6,36 [95%CI 0,91–44.40]; p=0.06), age (OR 2.06 [1.30–3.27]; p<0.002), chronic heart failure (CHF) (OR 2.78 [1.25–6.2]; р=0.012), Hamilton depression scale score (OR 1,18 [1.03–1.34]; р=0.016), cognitive dysfunction score (Roschina scale) (OR 1.20 [1.05–1.35]; р=0.006), and age — body mass index interaction (OR 0,98 [0,97–0,997]; р = 0,013). The predicted probability of death within the next 5 years in men and women was 22,9% and 6,7%, respectively. The highest score of cognitive dysfunction was associated with a 25% predicted probability of death and the lowest, with a 2% probability of death; predicted probabilities of death for the highest and lowest depression scores were 26% and 2%, respectively. The 5-year predicted probability of death in the patients without CHF was 6,7%, with CHF I NYHA functional class, 9,8%, II functional class 13,6%, III functional class 18,2%, and IV functional class 23,5%. All other baseline clinical, laboratory, demographic, psychological and socioeconomic variables were not significantly associated with the 5-year survival rate. The model was not verified on an external cohort.CONCLUSION: Cognitive dysfunction and depression have a significant negative impact on the 5-year mortality rate at much higher degree, than glycemic control, any diabetes-related complications and cardiovascular disorders, excluding CHF. The results obtained highlight the importance of the diagnosis and treatment of depression and cognitive dysfunction in type 2 diabetes mellitus

Analysis of Bj fibroblasts mitochondrial respiratory chain function under glucose starvation and exposure to different doses of rotenone: Implications for neurogenerative diseases

Certain neurodegenerative diseases, such as Parkinson and Alzheimer, are characterizing by an impairment in mitochondrial function and biogenesis, which may lead to pathological changes in the central nervous system. From this putative link stems a growing interest in changes to the mitochondrial electron transport chain and the ensuing energy dysfunction in neuronal cells and connective tissue cells under normal and pathological conditions. Fibroblasts involved in the formation of microenvironments of different types of specialized cells from the nervous system and their dysfunction may contribute to the pathogenesis of disease as well. In this regard, we have obtained stressful conditions of human dermal fibroblasts approximating of the pathological phenotype observed in Parkinson's disease. Was studied the expression and activity of the protein complexes of the mitochondria respiratory chain including translocase TOM20 under inhibition of NADH dehydrogenase and maintaining of oxidative stress

Оценка цифровизации взаимодействия государства и граждан

The purpose of this paper is to develop a comprehensive approach to evaluating digitalization of interaction of the state and citizens in the sphere of providing state services. The objectives of the study include the analysis of current Russian and foreign approaches to assessing the digitalization of interaction between the state and citizens; development and testing of a composite indicator methodology for conducting such an assessment in the provision of public services. Materials and methods. When preparing the paper, the authors studied Russian and foreign theoretical and practical approaches to evaluating digitalization of interaction between the state and citizens. The approbation of the digitalization index of interaction between the state and citizens proposed in the article was carried out on the basis of data from a selective federal statistical observation of the Federal State Statistics Service on the use of information technologies, information and communication networks by the population, as well as the data from the Ministry of Economic Development of the Russian Federation. To achieve the objective, theoretical methods (comparative analysis, synthesis, and generalization), modelling, and correlation analysis were used. Results. Based on the analysis of foreign and Russian approaches, their advantages and limitations, the article substantiates the methodology for calculating the digitalization index of interaction between the state and citizens, taking into account the immediate results (the availability of state and municipal services in the electronic form), intermediate results (the demand for the electronic form of service provision) and the final results of digital transformation in the provision of public services (satisfaction of citizens with the quality of services provided in the electronic form), as well as the risks of digital interaction (the level of digital trust of citizens in the interaction with the state). Approbation of the digitalization index of interaction between the state and citizens in the regional context was carried out. To assess the applicability of the proposed index, the correlation dependence of its values and the values of the index components on the level of education of the population, employment, income and urbanization, as well as differences in the availability of information and communication technologies infrastructure was investigated. At the same time, the level of digitalization correlation of interaction between the state and citizens with social factors is higher than with infrastructural ones. This means that to solve the problem of digital inequality in Russian regions, it is not enough to provide universal access to the Internet; factors of human capital development also play an important role in promoting digital channels of interaction. Conclusion. Assessing the digitalization of interaction between the state and citizens requires taking into account various indicators that reflect the immediate, intermediate and final results of such an interaction, as well as the risks associated with the transition to “digit”. In terms of the provision of public services for such an assessment, it is advisable to use the digitalization index of interaction between the state and citizens. Further promising areas of research in the field of assessing the digitalization of interaction between the state and citizens are related to the study of the influence of citizens’ trust in government bodies on the level of digitalization of interaction between the state and citizens, as well as taking into account the interaction of citizens and the state within the framework of other types of state functions (development and implementation of state policy, regulation, control and supervisory activities). The implementation of these directions will require the expansion of the currently available information base.Целью исследования является выработка комплексного подхода к оценке цифровизации взаимодействия государства и граждан в сфере оказания государственных услуг. В задачи исследования входит анализ действующих российских и зарубежных подходов к оценке цифровизации взаимодействия государства и граждан; разработка и апробация методологии комплексного показателя для проведения такой оценки в сфере оказания государственных услуг. Материалы и методы. При подготовке статьи авторами изучены российские и зарубежные теоретические и практические подходы к оценке цифровизации взаимодействия государства и граждан. Апробация предложенного в статье индекса цифровизации взаимодействия государства и граждан проведена на основе данных выборочного федерального статистического наблюдения Федеральной службы государственной статистики по вопросам использования населением информационных технологий и информационно-коммуникационных сетей, а также данных Министерства экономического развития Российской Федерации. Для достижения цели использованы теоретические методы (сравнительный анализ, синтез, обобщение), моделирование и корреляционный анализ. Результаты. Исходя из анализа зарубежных и российских подходов, их преимуществ и ограничений, в статье обоснована методология расчета индекса цифровизации взаимодействия государства и граждан, учитывающего непосредственные результаты (наличие государственных и муниципальных услуг в электронном виде), промежуточные результаты (востребованность электронной формы оказания услуг) и конечные результаты цифровой трансформации в сфере оказания государственных услуг (удовлетворенность граждан качеством оказываемых услуг в электронном виде), а также риски цифрового взаимодействия (уровень цифрового доверия граждан при взаимодействии с государством). Проведена апробация индекса цифровизации взаимодействия государства и граждан в региональном разрезе. Для оценки применимости предложенного индекса исследована корреляционная зависимость его значений и значений компонентов индекса от уровня образования населения, занятости, доходов и урбанизации, так и различиями в доступности инфраструктуры информационно-коммуникационных технологий. При этом уровень корреляции цифровизации взаимодействия государства и граждан с социальными факторами выше, чем с инфраструктурными. Это означает, что для решения проблемы цифрового неравенства российских регионов недостаточно обеспечить универсальный доступ к сети Интернет; важную роль в продвижении цифровых каналов взаимодействия играют и факторы развития человеческого капитала. Заключение. Оценка цифровизации взаимодействия государства и граждан требует учета различных показателей, отражающих непосредственные, промежуточные и конечные результаты такого взаимодействия, а также риски, связанные с переходом к «цифре». В части оказания государственных услуг для такой оценки целесообразно использовать индекс цифровизации взаимодействия государства и граждан. Дальнейшие перспективные направления исследований в сфере оценки цифровизации взаимодействия государства и граждан связаны с изучением влияния доверия граждан к органам государственного управления на уровень цифровизации взаимодействия государства и граждан, а также с учетом взаимодействия граждан и государства в рамках иных видов государственных функций (выработки и реализации государственной политики, регулирования, контрольно-надзорной деятельности). Реализация этих направлений потребует расширения имеющейся в настоящее время информационной базы

IMMUNE PREDICTORS OF FIBROGENESIS AND THEIR APPLICATION FOR NON-INVASIVE DIAGNOSTICS OF LIVER FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS

The study was devoted to development of non-invasive methods for diagnosis of liver fibrosis in patients with chronic viral hepatitis (CVH). The stepwise logistic multivariate regression analysis of biochemical (PTI, glucose, albumin, AST, LDH) and immunological parameters (the functional activity of neutrophils and monocytes, the relative content of CD8+ T- and CD19+B-cells) was used for the establishment of diagnostic model. Based on the multiple regression analysis we derived a 2 novel Integral Indexes of Liver Fibrosis (IILF-biochem and IILF-immun, respectively). It is shown that IILF-biochem allows, without resorting to liver biopsy to predict the appropriate stage of fibrosis in CHV patients with diagnostic accuracy of 86—87 %, and in combination with IILF — at 97.7 %

Efficacy of metformin for treatment and prevention of antipsychotic-induced overweight and obesity in women: an open-label, randomized, prospective placebo-controlled study

Background: The prevalence of obesity and metabolic abnormalities is increased patients with mental disorders receiving psychopharmacotherapy, which significantly impairs their treatment adherence.Aims: To evaluate the efficacy and safety of metformin in prevention and treatment obesity and overweight in patients with mental disorders receiving antipsychotics.Materials and methods: This was an open-label, prospective, randomized, placebo-controlled study of female patients with mental disorders (age, 18 to 50). The patients were randomized into two groups in a 2:1 ratio: the treatment group received metformin and the control group received placebo. Metformin was administered at a starting dose of 500 mg daily, with subsequent up-titration every 2 weeks when necessary, up to 2000 mg daily. The treatment duration was 6 months.Results: Baseline BMI in the treatment group (N=62) was 27,3 [24,0; 30,4] kg/m2; it decreased to 26,0 [22,5; 30,5] kg/m2, p < 0.0001, Wilсoxon test) after 6 months of treatment. The patients receiving metformin decreased their body weight by 3 [-6; 0] kg, or  -4,0 [-8; 0] %. In the placebo group (N=30), the baseline BMI was 27,5 [24,0; 32,0] kg/m2 and increased to 28,2 [25,8; 34,0] kg/m2 at 6 month (p=0.001, Wilсoxon test), or 3 [1; 6] kg. After 6 months of treatment, the difference in BMI between the metformin and placebo groups was significant (26,0 и 28,2 kg/m2, respectively, р=0,027, Mann-Withney test). Six (6) of 62 patients treated with metformin had side effects and were switched to an equivalent dose of prolonged release metformin, with reduction of side effects in 5 of them.Conclusions: The use of metformin in patients with mental disorders receiving antipsychotics allows for reduction or stabilization of body weight in 80% of cases, with ≥5% decrease of body weight in 44% of patients. It is recommended to start metformin at a dose of 500 mg daily with subsequent up-titration of up to 2000 mg if necessary