Low-G fluid transfer technology study, executive summary

For abstract, see N76-24502

New Uses for Sensitivity Analysis: How Different Movement Tasks Effect Limb Model Parameter Sensitivity

Original results for a newly developed eight-order nonlinear limb antagonistic muscle model of elbow flexion and extension are presented. A wider variety of sensitivity analysis techniques are used and a systematic protocol is established that shows how the different methods can be used efficiently to complement one another for maximum insight into model sensitivity. It is explicitly shown how the sensitivity of output behaviors to model parameters is a function of the controller input sequence, i.e., of the movement task. When the task is changed (for instance, from an input sequence that results in the usual fast movement task to a slower movement that may also involve external loading, etc.) the set of parameters with high sensitivity will in general also change. Such task-specific use of sensitivity analysis techniques identifies the set of parameters most important for a given task, and even suggests task-specific model reduction possibilities

Space LOX vent system

The research of the program to design and build a prototype vent system capable of exhausting only vapor to space from an all liquid or two-phase mixture of oxygen, while operating under low or zero-gravity conditions is reported. Work performed during the detail design phase of the program was concerned with the finalization of vent system performance, development of component specifications, solicitation of vendor bids, selection of components and overall system package design. The compact system preliminary design defined for the comparisons was reviewed in light of a desirability to demonstrate complete tank mixing at one-g. Also, performance of the system at low-g conditions with a full tank and maximum temperature stratification or maximum pressure rise between vent cycles was investigated. It was found that under these extreme conditions, not previously considered, that use of a larger pump mixer than previously defined would be desirable. In addition, to simplify ground testing with only a small weight penalty, the exchanger vent pressure was increased from 5 psia to 22 psia nominal. This resulted in less than a 0.2% increase in system weight

On the capacity of channels with block memory

The capacity of channels with block memory is investigated. It is shown that, when the problem is modeled as a game-theoretic problem, the optimum coding and noise distributions when block memory is permitted are independent from symbol to symbol within a block. Optimal jamming strategies are also independent from symbol to symbol within a block

Mnemonic discrimination relates to perforant path integrity: An ultra-high resolution diffusion tensor imaging study.

Pattern separation describes the orthogonalization of similar inputs into unique, non-overlapping representations. This computational process is thought to serve memory by reducing interference and to be mediated by the dentate gyrus of the hippocampus. Using ultra-high in-plane resolution diffusion tensor imaging (hrDTI) in older adults, we previously demonstrated that integrity of the perforant path, which provides input to the dentate gyrus from entorhinal cortex, was associated with mnemonic discrimination, a behavioral outcome designed to load on pattern separation. The current hrDTI study assessed the specificity of this perforant path integrity-mnemonic discrimination relationship relative to other cognitive constructs (identified using a factor analysis) and white matter tracts (hippocampal cingulum, fornix, corpus callosum) in 112 healthy adults (20-87 years). Results revealed age-related declines in integrity of the perforant path and other medial temporal lobe (MTL) tracts (hippocampal cingulum, fornix). Controlling for global effects of brain aging, perforant path integrity related only to the factor that captured mnemonic discrimination performance. Comparable integrity-mnemonic discrimination relationships were also observed for the hippocampal cingulum and fornix. Thus, whereas perforant path integrity specifically relates to mnemonic discrimination, mnemonic discrimination may be mediated by a broader MTL network

Collisional Grooming Models of the Kuiper Belt Dust Cloud

We modeled the 3-D structure of the Kuiper Belt dust cloud at four different dust production rates, incorporating both planet-dust interactions and grain-grain collisions using the collisional grooming algorithm. Simulated images of a model with a face-on optical depth of ~10^-4 primarily show an azimuthally-symmetric ring at 40-47 AU in submillimeter and infrared wavelengths; this ring is associated with the cold classical Kuiper Belt. For models with lower optical depths (10^-6 and 10^-7), synthetic infrared images show that the ring widens and a gap opens in the ring at the location of of Neptune; this feature is caused by trapping of dust grains in Neptune's mean motion resonances. At low optical depths, a secondary ring also appears associated with the hole cleared in the center of the disk by Saturn. Our simulations, which incorporate 25 different grain sizes, illustrate that grain-grain collisions are important in sculpting today's Kuiper Belt dust, and probably other aspects of the Solar System dust complex; collisions erase all signs of azimuthal asymmetry from the submillimeter image of the disk at every dust level we considered. The model images switch from being dominated by resonantly-trapped small grains ("transport dominated") to being dominated by the birth ring ("collision dominated") when the optical depth reaches a critical value of tau ~ v/c, where v is the local Keplerian speed.Comment: 31 pages, including 9 figure

Limbic Tract Integrity Contributes to Pattern Separation Performance Across the Lifespan.

Accurate memory for discrete events is thought to rely on pattern separation to orthogonalize the representations of similar events. Previously, we reported that a behavioral index of pattern separation was correlated with activity in the hippocampus (dentate gyrus, CA3) and with integrity of the perforant path, which provides input to the hippocampus. If the hippocampus operates as part of a broader neural network, however, pattern separation would likely also relate to integrity of limbic tracts (fornix, cingulum bundle, and uncinate fasciculus) that connect the hippocampus to distributed brain regions. In this study, healthy adults (20-89 years) underwent diffusion tensor imaging and completed the Behavioral Pattern Separation Task-Object Version (BPS-O) and Rey Auditory Verbal Learning Test (RAVLT). After controlling for global effects of brain aging, exploratory skeleton-wise and targeted tractography analyses revealed that fornix integrity (fractional anisotropy, mean diffusivity, and radial diffusivity; but not mode) was significantly related to pattern separation (measured using BPS-O and RAVLT tasks), but not to recognition memory. These data suggest that hippocampal disconnection, via individual- and age-related differences in limbic tract integrity, contributes to pattern separation performance. Extending our earlier work, these results also support the notion that pattern separation relies on broad neural networks interconnecting the hippocampus

Recognition Memory Dysfunction Relates to Hippocampal Subfield Volume: A Study of Cognitively Normal and Mildly Impaired Older Adults.

ObjectivesThe current study examined recognition memory dysfunction and its neuroanatomical substrates in cognitively normal older adults and those diagnosed with mild cognitive impairment (MCI).MethodsParticipants completed the Mnemonic Similarity Task, which provides simultaneous measures of recognition memory and mnemonic discrimination. They also underwent structural neuroimaging to assess volume of medial temporal cortex and hippocampal subfields.ResultsAs expected, individuals diagnosed with MCI had significantly worse recognition memory performance and reduced volume across medial temporal cortex and hippocampal subfields relative to cognitively normal older adults. After controlling for diagnostic group differences, however, recognition memory was significantly related to whole hippocampus volume, and to volume of the dentate gyrus/CA3 subfield in particular. Recognition memory was also related to mnemonic discrimination, a fundamental component of episodic memory that has previously been linked to dentate gyrus/CA3 structure and function.DiscussionResults reveal that hippocampal subfield volume is sensitive to individual differences in recognition memory in older adults independent of clinical diagnosis. This supports the notion that episodic memory declines along a continuum within this age group, not just between diagnostic groups

Doppler Modulation of X-ray lines in Cygnus X-3

We measured Doppler shifts of three bright spectral lines in the X-ray emission from Cygnus X-3 as recorded by the Chandra X-Ray Observatory. Doppler shifts of lines associated with Si XIV and S XVI exhibit orbital modulation. The magnitude and phasing of this modulation relative to the orbital ephemeris indicate the location of the source of this emission within the wind emanating from the compact object's companion. These observations enable us to make an indirect measurement of the separation of the two stars. Under certain assumptions our observation of a line associated with Fe XXV also limits the mass of the compact object M < 3.6 MSun.Comment: 7 pages, 3 figures, Accepted for publication in The Astrophysical Journal Letter