Exploring the Knowledge Landscape of <em>Escherichia coli</em> Research: A Scientometric Overview

Escherichia coli (E. coli) has the hallmark of being the most extensively studied organism. This is shown by the thousands of articles published since its discovery by T. Escherich in 1885. On the other hand, very little is known about the intellectual landscape in E. coli research. For example, how the trend of publications on E. coli has evolved over time and which scientific topics have been the focus of interest for researchers. In this chapter, we present the results of a large-scale scientometric analysis of about 100,000 bibliographic records from PubMed over the period 1981–2021. To examine the evolution of research topics over time, we divided the dataset into four intervals of equal width. We created co-occurrence networks from keywords indexed in the Medical Subject Headings vocabulary and systematically examined the structure and evolution of scientific knowledge about E. coli. The extracted research topics were visualized in strategic diagrams and qualitatively characterized in terms of their maturity and cohesion

Two Tales of Prokaryotic Genomic Diversity: Escherichia coli and Halophiles

Jedna je od općenitih značajki prokariota velika raznolikost genoma, na što utječu mutacije, horizontalni prijenos gena, prisutnost bakteriocina i bakterijskih virusa. Iznimna se genomska raznolikost razvila kao posljedica izlaganja mikroorganizama stresu i njihove prilagodbe različitim uvjetima okoliša. U radu su predstavljena dva primjera raznolikosti prokariota: genetska varijabilnost jedinki vrste Escherichia coli i raznolikost mikroorganizama prisutnih u slanim staništima, praćena raspravom o zdravstvenim problemima uzrokovanim unosom kontaminirane hrane i mogućnosti primjene mikroorganizama u biotehnologiji.Prokaryotes are generally characterized by vast genomic diversity that has been shaped by mutations, horizontal gene transfer, bacteriocins and phage predation. Enormous genetic diversity has developed as a result of stresses imposed in harsh environments and the ability of microorganisms to adapt. Two examples of prokaryotic diversity are presented: on intraspecies level, exemplified by Escherichia coli, and the diversity of the hypersaline environment, with the discussion of food-related health issues and biotechnological potential

The Universe of Escherichia coli

The title of the book ""The Universe of Escherichia coli"" aims to present and emphasize the huge diversity of this bacterial species and our efforts to prevent the E. coli infections. As it is part of the gut microbiota, E. coli is a well-known commensal species, and probiotic E. coli strains are successfully used for improving host's health. Also many ""workhorse"" E. coli strain exist that are employed in laboratory and biotechnology settings. But certain E. coli strains can cause intestinal and also extraintestinal infections at many anatomical sites. Therefore many efforts are undertaken to prevent E. coli infections, among them food safety, vaccines, but also new antimicrobial agents are searched for