699 research outputs found

    UK Strategy in the Gulf and Middle East After American Retrenchment

    Get PDF
    This is the final version. Available from SETA Foundation via the DOI in this recordThis paper considers the impact of the possible relative decline of the U.S. and its engagement in the Middle East and the Gulf in particular. US disengagement started under the Obama administration and seems to be continuing under the Trump administration. Applying theories of ā€˜rival hegemonic transition,ā€™ possible post-Amercan successors are identified. In particular, the UKā€™s intents, capabilities, and strategies as it returns ā€˜East of Suezā€™ are examined, along with the geopolitical implications of such a return for the shifting balance of power in the Middle East

    tRNA properties help shape codon pair preferences in open reading frames

    Get PDF
    Translation elongation is an accurate and rapid process, dependent upon efficient juxtaposition of tRNAs in the ribosomal A- and P-sites. Here, we sought evidence of A- and P-site tRNA interaction by examining bias in codon pair choice within open reading frames from a range of genomes. Three distinct and marked effects were revealed once codon and dipeptide biases had been subtracted. First, in the majority of genomes, codon pair preference is primarily determined by a tetranucleotide combination of the third nucleotide of the P-site codon, and all 3 nt of the A-site codon. Second, pairs of rare codons are generally under-used in eukaryotes, but over-used in prokaryotes. Third, the analysis revealed a highly significant effect of tRNA-mediated selection on codon pairing in unicellular eukaryotes, Bacillus subtilis, and the gamma proteobacteria. This was evident because in these organisms, synonymous codons decoded in the A-site by the same tRNA exhibit significantly similar P-site pairing preferences. Codon pair preference is thus influenced by the identity of A-site tRNAs, in combination with the P-site codon third nucleotide. Multivariate analysis identified conserved nucleotide positions within A-site tRNA sequences that modulate codon pair preferences. Structural features that regulate tRNA geometry within the ribosome may govern genomic codon pair patterns, driving enhanced translational fidelity and/or rate

    Dysphagia assessment and intervention: evaluating inclusive approaches using video

    Get PDF
    Purpose: Dysphagia experienced by adults with mental health conditions and/or intellectual disabilities (IDs) has been well-reported. However, accessible and inclusive assessment measures to identify and monitor for deterioration in dysphagia are very limited. The purpose of this paper is to explore the use of video to enhance inclusion in dysphagia assessment and intervention for an inpatient setting. Design/methodology/approach: This service evaluation involved adults with IDs and mental illness living in in-patient accommodation and their multidisciplinary team. Participants were invited to film and then reflect on videos and their comments were transcribed for qualitative analysis. Findings: In total, 42 adults gave consent to film, review and discuss mealtime video-clips. Staff feedback was invited. Thematic analysis was conducted for service-user and staff comments. A global theme of ā€œinvolvementā€ was identified from the data analysis, with sub-themes of ā€œenhancing participation, insight and incentiveā€. An additional global theme ā€œclinical benefitsā€ resulted from staff comments. This included sub-themes of breadth of assessment, shared working and outcome measures. Research limitations/implications: Limitations included refusal of video by people with heightened anxiety but these were a minority. Most people showed enthusiasm and enhanced engagement. Practical issues were resolved regarding governance. Practical implications: Video offers a dynamic record of muscle tone, coordination, mealtime experience and individual context benefiting both service-user and staff practice. It stimulates insightful discussion of outcomes and supports the inclusion of service-user perspectives. Further research is indicated to develop a greater understanding of dysphagia in this population. Inclusion of service-users in planning and managing safer mealtimes may be enhanced through the sensitive use of video. Social implications: This evaluation suggests opportunities for improving inclusive approaches for service-users using video to promote insight. Originality/value: Further research is indicated to explore the nature of dysphagia in people with mental health conditions using video as a dynamic and unique resource

    Chapter 3: Mental health treatment and services

    Get PDF
    In this chapter reported use of psychotropic medication and psychological therapy are examined, as well as the extent of use of health care services for a mental health reason (GP, inpatient and outpatient health care) and day and community service use. It should be noted that rates presented are based on participant self-reports, not health records. Misclassifications of type of treatment or service are possible, and which was the providing organisation was not established

    What helps to support people affected by Adverse Childhood Experiences? A review of evidence

    Get PDF
    Adverse Childhood Experiences (ACEs) include physical, sexual or emotional abuse; neglect; domestic violence in the home; homelessness or living in care; parental mental health problems or substance abuse; and parents who are absent through imprisonment, separation or death. We sought to understand how people affected by ACEs can best be supported by conducting a review of evidence. The review involved three components: a qualitative synthesis of UK views studies; a systematic review of reviews which measured the effectiveness of interventions to support people affected by ACEs; and a stakeholder workshop with young people with lived experience of ACEs. The review was commissioned by the Department of Health and Social Care

    Content analysis of the professional journal of the Royal College of Speech and Language Therapists, III: 1966ā€“2015ā€”into the 21st century

    Get PDF
    Ā© 2017 Royal College of Speech and Language Therapists Background: Following content analyses of the first 30 years of the UK speech and language therapy professional body's journal, this study was conducted to survey the published work of the speech (and language) therapy profession over the last 50 years and trace key changes and themes. Aim: To understand better the development of the UK speech and language therapy profession over the last 50 years. Methods & Procedures: All volumes of the professional journal of the Royal College of Speech and Language Therapists published between 1966 and 2015 (British Journal of Communication Disorders, European Journal of Communication Disorders and International Journal of Language and Communication Disorders) were examined using content analysis. The content was compared with that of the same journal as it appeared from 1935 to 1965. Outcomes & Results: The journal has shown a trend towards more multi-authored and international papers, and a formalization of research methodologies. The volume of papers has increased considerably. Topic areas have expanded, but retain many of the areas of study found in earlier issues of the journal. Conclusions & Implications: The journal and its articles reflect the growing complexity of conditions being researched by speech and language therapists and their professional colleagues and give an indication of the developing evidence base for intervention and the diverse routes which speech and language therapy practice has taken over the last 50 years
    • ā€¦
    corecore