328 research outputs found
Social Experimentation as Reflection-in-A ction
We present the results of our review of some forty community-level interventions undertaken in the developing world over the past twenty years m order to reduce malnourishment in children. We argue that such interventions, if they are considered as social experiments, cannot be assimilated to models of quasi-experimental method. We propose an alternative model of experimentation, which we call "reflection-in-action", which seems to us better suited to account for the kinds ofvahdity and rigor attainable in situations such as these.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68568/2/10.1177_107554708400600101.pd
Combinatorial Markov chains on linear extensions
We consider generalizations of Schuetzenberger's promotion operator on the
set L of linear extensions of a finite poset of size n. This gives rise to a
strongly connected graph on L. By assigning weights to the edges of the graph
in two different ways, we study two Markov chains, both of which are
irreducible. The stationary state of one gives rise to the uniform
distribution, whereas the weights of the stationary state of the other has a
nice product formula. This generalizes results by Hendricks on the Tsetlin
library, which corresponds to the case when the poset is the anti-chain and
hence L=S_n is the full symmetric group. We also provide explicit eigenvalues
of the transition matrix in general when the poset is a rooted forest. This is
shown by proving that the associated monoid is R-trivial and then using
Steinberg's extension of Brown's theory for Markov chains on left regular bands
to R-trivial monoids.Comment: 35 pages, more examples of promotion, rephrased the main theorems in
terms of discrete time Markov chain
Scaling properties in off equilibrium dynamical processes
In the present paper, we analyze the consequences of scaling hypotheses on
dynamic functions, as two times correlations . We show, under general
conditions, that must obey the following scaling behavior , where the scaling variable is
and , two
undetermined functions. The presence of a non constant exponent
signals the appearance of multiscaling properties in the dynamics.Comment: 6 pages, no figure
Discrete molecular dynamics simulations of peptide aggregation
We study the aggregation of peptides using the discrete molecular dynamics
simulations. At temperatures above the alpha-helix melting temperature of a
single peptide, the model peptides aggregate into a multi-layer parallel
beta-sheet structure. This structure has an inter-strand distance of 0.48 nm
and an inter-sheet distance of 1.0 nm, which agree with experimental
observations. In this model, the hydrogen bond interactions give rise to the
inter-strand spacing in beta-sheets, while the Go interactions among side
chains make beta-strands parallel to each other and allow beta-sheets to pack
into layers. The aggregates also contain free edges which may allow for further
aggregation of model peptides to form elongated fibrils.Comment: 15 pages, 8 figure
Hopf algebras and Markov chains: Two examples and a theory
The operation of squaring (coproduct followed by product) in a combinatorial
Hopf algebra is shown to induce a Markov chain in natural bases. Chains
constructed in this way include widely studied methods of card shuffling, a
natural "rock-breaking" process, and Markov chains on simplicial complexes.
Many of these chains can be explictly diagonalized using the primitive elements
of the algebra and the combinatorics of the free Lie algebra. For card
shuffling, this gives an explicit description of the eigenvectors. For
rock-breaking, an explicit description of the quasi-stationary distribution and
sharp rates to absorption follow.Comment: 51 pages, 17 figures. (Typographical errors corrected. Further fixes
will only appear on the version on Amy Pang's website, the arXiv version will
not be updated.
Automated quantification of the landing error scoring system with a markerless motion-Capture system
Context: The Landing Error Scoring System (LESS) can be used to identify individuals with an elevated risk of lower extremity injury. The limitation of the LESS is that raters identify movement errors from video replay, which is time-consuming and, therefore, may limit its use by clinicians. A markerless motion-capture system may be capable of automating LESS scoring, thereby removing this obstacle. Objective: To determine the reliability of an automated markerless motion-capture system for scoring the LESS. Design: Cross-sectional study. Setting: United States Military Academy. Patients or Other Participants: A total of 57 healthy, physically active individuals (47 men, 10 women; age ¼ 18.6 6 0.6 years, height ¼ 174.5 6 6.7 cm, mass ¼ 75.9 6 9.2 kg). Main Outcome Measure(s): Participants completed 3 jump-landing trials that were recorded by standard video cameras and a depth camera. Their movement quality was evaluated by expert LESS raters (standard video recording) using the LESS rubric and by software that automates LESS scoring (depth-camera data). We recorded an error for a LESS item if it was present on at least 2 of 3 jump-landing trials. We calculated j statistics, prevalence- and bias-adjusted j (PABAK) statistics, and percentage agreement for each LESS item. Interrater reliability was evaluated between the 2 expert rater scores and between a consensus expert score and the markerless motion-capture system score. Results: We observed reliability between the 2 expert LESS raters (average j ¼ 0.45 6 0.35, average PABAK ¼ 0.67 6 0.34; percentage agreement ¼ 0.83 6 0.17). The markerless motion-capture system had similar reliability with consensus expert scores (average j ¼ 0.48 6 0.40, average PABAK ¼ 0.71 6 0.27; percentage agreement ¼ 0.85 6 0.14). However, reliability was poor for 5 LESS items in both LESS score comparisons. Conclusions: A markerless motion-capture system had the same level of reliability as expert LESS raters, suggesting that an automated system can accurately assess movement. Therefore, clinicians can use the markerless motion-capture system to reliably score the LESS without being limited by the time requirements of manual LESS scoring
Water-like anomalies for core-softened models of fluids: One dimension
We use a one-dimensional (1d) core-softened potential to develop a physical
picture for some of the anomalies present in liquid water. The core-softened
potential mimics the effect of hydrogen bonding. The interest in the 1d system
stems from the facts that closed-form results are possible and that the
qualitative behavior in 1d is reproduced in the liquid phase for higher
dimensions. We discuss the relation between the shape of the potential and the
density anomaly, and we study the entropy anomaly resulting from the density
anomaly. We find that certain forms of the two-step square well potential lead
to the existence at T=0 of a low-density phase favored at low pressures and of
a high-density phase favored at high pressures, and to the appearance of a
point at a positive pressure, which is the analog of the T=0 ``critical
point'' in the Ising model. The existence of point leads to anomalous
behavior of the isothermal compressibility and the isobaric specific heat
.Comment: 22 pages, 7 figure
Transfer Matrices and Partition-Function Zeros for Antiferromagnetic Potts Models. V. Further Results for the Square-Lattice Chromatic Polynomial
We derive some new structural results for the transfer matrix of
square-lattice Potts models with free and cylindrical boundary conditions. In
particular, we obtain explicit closed-form expressions for the dominant (at
large |q|) diagonal entry in the transfer matrix, for arbitrary widths m, as
the solution of a special one-dimensional polymer model. We also obtain the
large-q expansion of the bulk and surface (resp. corner) free energies for the
zero-temperature antiferromagnet (= chromatic polynomial) through order q^{-47}
(resp. q^{-46}). Finally, we compute chromatic roots for strips of widths 9 <=
m <= 12 with free boundary conditions and locate roughly the limiting curves.Comment: 111 pages (LaTeX2e). Includes tex file, three sty files, and 19
Postscript figures. Also included are Mathematica files data_CYL.m and
data_FREE.m. Many changes from version 1: new material on series expansions
and their analysis, and several proofs of previously conjectured results.
Final version to be published in J. Stat. Phy
Associations Between Slower Walking Speed and T1ρ Magnetic Resonance Imaging of Femoral Cartilage Following Anterior Cruciate Ligament Reconstruction
Objective: To determine whether walking speed, collected at 6 and 12 months following anterior cruciate ligament reconstruction (ACLR), is associated with inter-extremity differences in proteoglycan density, measured via T1ρ magnetic resonance imaging, in tibiofemoral articular cartilage 12 months following ACLR. Methods: Twenty-one individuals with a unilateral patellar-tendon autograft ACLR (10 women and 11 men, mean ± SD age 23.9 ± 2.7 years, mean ± SD body mass index 23.9 ± 2.7 kg/m2) were recruited for participation in this study. Walking speed was collected using 3-dimensional motion capture at 6 and 12 months following ACLR. The articular cartilage of the medial femoral condyle (MFC) and lateral femoral condyle and medial and lateral tibial condyles was manually segmented and subsectioned into 3 regions of interest (anterior, central, and posterior) based on the location of the meniscus in the sagittal plane. Inter-extremity mean T1ρ relaxation time ratios (T1ρ ACLR extremity / T1ρ contralateral extremity) were calculated and used for analysis. Pearson product-moment correlations were used to determine associations between walking speed and inter-extremity differences in T1ρ relaxation time ratios. Results: Slower walking speed 6 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the MFC of the ACLR extremity 12 months following ACLR (posterior MFC, r = −0.51, P = 0.02; central MFC, r = −0.47, P = 0.04). Similarly, slower walking speed at 12 months post-ACLR was significantly associated with higher T1ρ relaxation time ratios in the posterior MFC ACLR extremity (r = −0.47, P = 0.04) 12 months following ACLR. Conclusion: Slower walking speed at 6 and 12 months following ACLR may be associated with early proteoglycan density changes in medial femoral compartment cartilage health in the first 12 months following ACLR
Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease
Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy.Mary M. Kavurma, Christina Bursill, Christopher P. Stanley, Freda Passam, Siân P. Cartland, Sanjay Patel, Jacky Loa, Gemma A. Figtree, Jonathan Golledge, Sarah Aitken, and David A. Robinso
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