728 research outputs found
Sex Does Not Affect Survival: A Propensity Score-Matched Comparison in a Homogenous Contemporary Radical Cystectomy Cohort.
OBJECTIVES
To determine whether biological sex affects oncological outcome after extended pelvic lymph node dissection, radical cystectomy, and urinary diversion for muscle-invasive bladder cancer, and to identify risk factors impacting outcome.
PATIENTS AND METHODS
We performed a single-center, retrospective observational cohort study with prospective data collection with a propensity score matched population. A total of 1165 consecutive patients from 2000 to 2020, (317 women and 848 men) scheduled for open extended pelvic lymph node dissection, radical cystectomy, and urinary diversion for urothelial bladder cancer were included in the final analysis. Overall Survival (OS), Cancer-Specific-Survival (CSS), and Recurrence-Free-survival (RFS) were assessed with multivariable weighted Cox regression analysis as well as with propensity score matched Cox-Regression.
RESULTS
No significant difference was found between sexes regarding OS (HR 1.18, [0.93-1.49], PÂ =Â .16), CSS (HR 0.87, [0.64-1.18], PÂ =Â .38), or RFS (HR 0.80, [0.59-1.07], PÂ =Â .13). These results were confirmed after propensity score matching: female sex was not associated with inferior OS (HR 1.20, [0.91-1.60], PÂ =Â .19), CSS (HR 1.01, [0.75-1.35], PÂ =Â .97) or RFS (HR 0.98, [0.75-1.27], PÂ =Â .86).
CONCLUSIONS
We did not find a significant difference in cancer-related outcomes or overall survival after extended pelvic lymph node dissection, open radical cystectomy, and urinary diversion for urothelial cancer between males and females even after adjustment with propensity matching score for multiple factors including oncological parameters, smoking status, and renal function
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Microscopic insight into the bilateral formation of carbon spirals from a symmetric iron core
Mirrored carbon-spirals have been produced from pressured ferrocene via the bilateral extrusion of the spiral pairs from an iron core. A parametric plot of the surface geometry displays the fractal growth of the conical helix made with the logarithmic spiral. Electron microscopy studies show the core is a crystalline cementite which grows and transforms its shape from spherical to biconical as it extrudes two spiralling carbon arms. In a cross section along the arms we observe graphitic flakes arranged in a herringbone structure, normal to which defects propagate. Local-wave-pattern analysis reveals nanoscale defect patterns of two-fold symmetry around the core. The data suggest that the bilateral growth originates from a globular cementite crystal with molten surfaces and the nano-defects shape emerging hexagonal carbon into a fractal structure. Understanding and knowledge obtained provide a basis for the controlled production of advanced carbon materials with designed geometries
Fluctuating magnetic moments in liquid metals
We re-analyze literature data on neutron scattering by liquid metals to show
that non-magnetic liquid metals possess a magnetic moment that fluctuates on a
picosecond time scale. This time scale follows the motion of the cage-diffusion
process in which an ion rattles around in the cage formed by its neighbors. We
find that these fluctuating magnetic moments are present in liquid Hg, Al, Ga
and Pb, and possibly also in the alkali metals.Comment: 17 pages, 5 figures, submitted to PR
Collective dynamics of liquid aluminum probed by Inelastic X-ray Scattering
An inelastic X-ray scattering experiment has been performed in liquid
aluminum with the purpose of studying the collective excitations at wavevectors
below the first sharp diffraction peak. The high instrumental resolution (up to
1.5 meV) allows an accurate investigation of the dynamical processes in this
liquid metal on the basis of a generalized hydrodynamics framework. The
outcoming results confirm the presence of a viscosity relaxation scenario ruled
by a two timescale mechanism, as recently found in liquid lithium.Comment: 8 pages, 7 figure
Tonische und phasische AkivitÀt des endokrinen Herzens bei kardiovaskulÀren Patienten und Patienten mit Leberzirrhose
Influence of Pacing Mode and Rate on Peripheral Levels of Atrial Natriuretic Peptide (ANP)
The effect of acute modifications of pacing mode and rate on plasma ANP levels was evaluated. ANP was determined in ten resting patients with ODD pacemokers due to binodal disease or intermittent second- and third-degree AV block. At 82/minute pacing rate the ANP plasma levels (normal range 2 to 30 fmol/mL) corresponded to those under AAI (4.05 ± 2.10 fmol/mL) and DDD (4.18 ± 2.02 fmol/mL) pacing, but increased significantly (P < 0.05) during VVI pacing (6.96 ± 3.70 fmol/mL). Acceleration of DDD stimulation frequency from 82 to 113/minutes led to significant increases of ANP levels by the factor of three in all chosen AV delays. The lowest ANP plasma levels were measured of 175 msec AV delay under 82/minute pacing rate in DDD mode. Under 113/minutes the differences of ANP concentration after variations of AV delays were less pronounced. The influences of altered atrial pressure and tension on ANP release are discussed to account for changes in ANP plasma levels following different modes and rates of pacemaker stimulation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75366/1/j.1540-8159.1989.tb01862.x.pd
Evidence of short time dynamical correlations in simple liquids
We report a molecular dynamics (MD) study of the collective dynamics of a
simple monatomic liquid -interacting through a two body potential that mimics
that of lithium- across the liquid-glass transition. In the glassy phase we
find evidences of a fast relaxation process similar to that recently found in
Lennard-Jones glasses. The origin of this process is ascribed to the
topological disorder, i.e. to the dephasing of the different momentum
Fourier components of the actual normal modes of vibration of the disordered
structure. More important, we find that the fast relaxation persists in the
liquid phase with almost no temperature dependence of its characteristic
parameters (strength and relaxation time). We conclude, therefore, that in the
liquid phase well above the melting point, at variance with the usual
assumption of {\it un-correlated} binary collisions, the short time particles
motion is strongly {\it correlated} and can be described via a normal mode
expansion of the atomic dynamics.Comment: 7 pages, 7 .eps figs. To appear in Phys. Rev.
The Graz seismo-electromagnetic VLF facility
Abstract. In this paper we describe the Graz seismo-electromagnetic very low frequency (VLF) facility, as part of the European VLF receiver network, together with the scientific objectives and results from two years operation. After a brief technical summary of the present system â with heritage from a predecessor facility â i.e. hardware, software, operational modes and environmental influences, we discuss results from statistical data and scientific events related to terrestrial VLF propagation over Europe
Inelastic X-ray scattering study of the collective dynamics in liquid sodium
Inelastic X-ray scattering data have been collected for liquid sodium at
T=390 K, i.e. slightly above the melting point. Owing to the very high
instrumental resolution, pushed up to 1.5 meV, it has been possible to
determine accurately the dynamic structure factor, , in a wide
wavevector range, nm, and to investigate on the dynamical
processes underlying the collective dynamics. A detailed analysis of the
lineshape of , similarly to other liquid metals, reveals the
co-existence of two different relaxation processes with slow and fast
characteristic timescales respectively. The present data lead to the conclusion
that: i) the picture of the relaxation mechanism based on a simple viscoelastic
model fails; ii) although the comparison with other liquid metals reveals
similar behavior, the data do not exhibit an exact scaling law as the principle
of corresponding state would predict.Comment: RevTex, 7 pages, 6 eps figures. Accepted by Phys. Rev.
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