Prospectus, October 26, 1973

STAFF PROFILES; Trustees Welcome Stugo President Kendricks To Board; Chills Highlight Haunted House; Only Two Of Seven Amendments Pass, Original Report Incorrect; Prospectus In Perspective: Impeachment Now; The Short Circuit; Cruisin\u27 \u2773; Senator Hulsizer Asks For Student Involvement; Letters From Our Readers; To the Faculty of Parkland College; Bowling Bulletin Board; Death By Hunger; TARGET Explained At Open House; Behind The Books; Scott I Deal With The Issues ; Human Development Seminar Slated; The History Of The Controversial Film - Salt Of The Earth ; S.W.A.M.P. Not A Fad; News Bulletin; Allman Bros. Come Through On Brothers and Sisters; Johnson We Take The Student Where He Is, and Build On That ; Campus Continues To Be Completed; Pre-Registration Additional Info; Mutt and Mortie; Leaders To Meet At Allerton This Saturday, Sunday; Debaters Shows Strength At Bradley Tourney; Health Center Free Clinic; Day Senators Outline Platforms; Slave Auction, Dance Today; President Releases Tapes; Marshall Wins PCFW Scholarship; A\u27s Repeat As World Champs, Dump N.Y. Mets In Seven Games; Wrist-Wrestling, Frisbie Contests To Be Held Soon; Monday\u27s Coach; Harriers Lose Flores Burnette, Will Run In Region IV Finals On Saturday, October 26; Fast Freddy\u27s Football Forecast; Fast Freddy Pays In Cash, Too; Female Winner Of Fast Freddy; Classified Ads; Champaign To Pick Up Leaves; Masters\u27 \u27Spoon River\u27 Comes To Parkland; A Column By And For Women; What The Signs Say; W. Virginia U. Hires Attorney; Who Will Listen?; Final Exam Schedule - Fall Quarter; Callboard; Sharing Group Recommends Eighthttps://spark.parkland.edu/prospectus_1973/1003/thumbnail.jp

Prospectus, November 9, 1973

FORD - OUR NEXT PRESIDENT?; Faculty, Staff Evaluations Adopted As College Policy; Fellowships For Women Announced; Student Senate Vice-President Resigns Post; Debaters Take Third At IVC Meet; Vandalism Suspected In Fire; Parkland To Participate In Conference; Declaration Of Impeachment; Prospectus In Perspective; Letters From Our Readers; Student Opinion Survey; President\u27s Comment; The Short Circuit; Behind The Books; Counselors And Question Marks; Zindars Shares Her Experiences; $6 Bid Tops In Vets Dance, Slave-Auction; UFO\u27s: Citizens Vs. Air Force; The Pinkertons Are At Parkland; Allied Health Program; November Student Activities Parkland College; American Assoc. Of Univ. Women Host General Meeting Nov. 11; Peterson Addresses Phi Beta Lambda; PLATO Popular With Students, Teachers; Cycle Mishap Injures One; Road Rally; Mutt and Mortie; Evening Program Diversified Next Quarter At P/C; Geology Flight Delayed; Final Exam Schedule - Fall Quarter; Costs At School Dominate P.C.A. Senate Meeting; \u27Passion Play\u27 Not Dull; P/C Gen. Biology-Pollution, Genetics Other Relevant Topics; No Grease-Monkey Graduatess At Parkland; Campus Leaders Exchange Ideas at Allerton Meeting; Parkland Co-Hosts Veterans Conference; TB Examinations; Classified Ads; A Column By And For Women: Originality, The Cell; Monday\u27s Coach; Jim Redman, Jane Hawthorne Grab Parkland\u27s First Road Rally; Football Finals To Be Held Tuesday; Fast Freddy\u27s Football Forecast; WVLJ Plans Broadcasts Of PC Basketball; Thompson Wins Fast Freddy As Upsets Abound; Local Volunteer Suggests Grants; Lost And Found; Earle, Seger Go To N.J.C.A.A. Nationals; Parkland Cagers Start Practice For Nov. 29 Debut With Millikin; Wrestlers Open Workouts, Seven Spots Open On 10-Man Roster; Parkland College Basketball Schedule 1973-74; Parkland College Wrestling Schedule 1973-74; Bowing Bulletin Board; Callboard; Changes In Calendar, Staff Status, Registration Proposed; Cade Re-elected Board Chairmanhttps://spark.parkland.edu/prospectus_1973/1002/thumbnail.jp

Prospectus, October 12, 1973

AGNEW RESIGNS VICE-PRESIDENCY; Small Turnout For Election; Prospectus Editors Announced; Walk Attracts Over 600; All Amendments Pass; Prospectus In Perspective: Excellent Bike Path Choice, Letters From Our Readers, New Magazine Coming, At this point in time.....; The Short Circuit; Drama Department Introduces New Lounge Theatre; United Way Campaign Begins; Announces $19,290 Bog Award; Ieardi Headlines Talent Program; Road Rally Club; New Breed of Businessman: Young College Graduate; Student Appointed As Board Member; New Concept For P/C Typing Classes; New Name, Faces For Magazine; Parkland Team To Debate At Bradley Oct. 20; Parkland Instructor Hospitalized at Mercy; PCA Appoints Student Affairs Committee Members; C-U Politics To Be Discussed At Forum; Walk For Mankind; Parkland Announces Bike Rules; Student Senate Reviews Charters, Future Plans; Gayle Wright Chosen To Advise Capstone; Vet\u27s Outreach Aids Readjustment; Prospectus Gains Two Campus Cartoonists; Seminar Planned On \u27Volunteering\u27; P/C Biologists At IACCB Convention; \u27Siege\u27 Shocking, Relevant Film; Faculty Members To Hold Offices; Winter Registration Information; Parkland Student Wins Santa Fe Scholarship; Birthday Wishes; Pre-Registration Benefits All; Target Program To Sponsor Open House; Women Voters Begin Sale Of ERA Bracelet; Ferlinghetti Sues San Francisco Police; Applications Must Be Filed; A Column By And For Women: Born To Be A Woman, The Way It Used To Be, The Lib, I Am Woman; Mutt and Mortie; Fast Freddy\u27s Football Forecast; Fall Intramural; Bowling Bulletin Board; Football Results; Dennis Bailen Wins Fast Freddy; Monday\u27s Coach; Rugby Play Not Football; Harriers Slump To Third, Fourth; Hiser Receives Babe Ruth Award; Graduation; TARGET Sets Sights On Juveniles; Classified Ads; Johnson Calls For Truth, Integrity; Gammon: \u27Everyone Born With Ability\u27; Student President\u27s Report; Lives Changed By Jesus Christ; Cruisin\u27 \u2773; Candidates Learn Voting Procedure; Speleunkers Travel Virgin Paths; Krannert Art Center Schedule; Illini Student Union Movies; Lab Develops Self-Study Habits; Callboard; Race To Fund Town With Doctor; Council Member Proposes Later Bar Hourshttps://spark.parkland.edu/prospectus_1973/1004/thumbnail.jp

Prospectus, December 14, 1973

MERRY CHRISTMAS, HAPPY NEW YEAR; College Officials Present Carol Frate Fund Money; Seniors Tour Campus During Visitation Week; Parkland Campus Parking Problems; Senate Considers Pool Tables, Clubs; Prospectus In Perspective; Industrial Giants Dominate Energy; Conveniamus Has Uncertain Future; The Short Circuit; Who Will Listen?; Debaters Take Second At Greenville Contest; Roberta Peters Well Received At Great Hall In Krannert Center; Represent P/C At ISU Union Games; Vacated Student Posts To Be Filled By Elections On Dec. 19-20; Amendments Would Clarify Constitution If Passed; Instructors Take Third Straight Fast Freddy ; Counseling\u27s Walk-In Office; A Column By And For Women: Merry Christmas; Female Psychology Instructor Dismissed For Lesbian Panel; P/C Women Start Democratic Club; Internship Program Developed; Music Groups To Give Christmas Shows; Student Government Elections Set; Prospectus Accepting New Applications; UFO\u27s and Air Force Politics; Doobie Brothers were \u27Just Alright With Me\u27; Scholarship Program Announced; Meetings Scheduled; Mutt and Mortie; Kohoutek (Coe-hoe-tek) Is Coming, And With It What Else?; Classified Ads; Cagers Off To Fast Start With Three Wins; Godspell - Worth the Wait; Callboard; John Moore To Head Ski Area; P/C Musical; Energy Crisis Strange, A Hoax According To Parkland Students; Energy Committee Organized; Tournament Time!; Learning Exchange At Parkland; WILL Radio Plans Car Pool Service; Monday\u27s Coach; Grapplers Host Double Dual Meet Saturday, Dec. 8; Illini Football Honored By C-U Rotary; Abbey Envisions Strong Team for 74 Indoor Season; Track Schedule; First Flights; Phi Beta Lambda Sponsors Raffle; I M Winter Sports Features Women-Men Basketball; Fast Freddy\u27s Football Forecast; Bout and Denhart Win Second Rally; Gay Raiders Invade CBS; Tau Epsilon And Phi Beta Lambda; Agnew Replaces TV\u27s \u27Let\u27s Make A Deal\u27; Resignation Forced By Constitutional Interpretation Of Student Government; High School Newspapers Can Swap With Prospectus; Two wheelers are gaining popularityhttps://spark.parkland.edu/prospectus_1973/1000/thumbnail.jp

Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase.

Inhibitors of bacterial dd-peptidases represent potential antibiotics. In the search for alternatives to beta-lactams, we have investigated a series of compounds designed to generate transition state analogue structures upon reaction with dd-peptidases. The compounds contain a combination of a peptidoglycan-mimetic specificity handle and a warhead capable of delivering a tetrahedral anion to the enzyme active site. The latter includes a boronic acid, two alcohols, an aldehyde, and a trifluoroketone. The compounds were tested against two low-molecular mass class C dd-peptidases. As expected from previous observations, the boronic acid was a potent inhibitor, but rather unexpectedly from precedent, the trifluoroketone [d-alpha-aminopimelyl(1,1,1-trifluoro-3-amino)butan-2-one] was also very effective. Taking into account competing hydration, we found the trifluoroketone was the strongest inhibitor of the Actinomadura R39 dd-peptidase, with a subnanomolar (free ketone) inhibition constant. A crystal structure of the complex between the trifluoroketone and the R39 enzyme showed that a tetrahedral adduct had indeed formed with the active site serine nucleophile. The trifluoroketone moiety, therefore, should be considered along with boronic acids and phosphonates as a warhead that can be incorporated into new and effective dd-peptidase inhibitors and therefore, perhaps, antibiotics