Equality cases for condenser capacity inequalities under symmetrization

It is well known that certain transformations decrease the capacity of a condenser. We prove equality statements for the condenser capacity inequalities under symmetrization and polarization without connectivity restrictions on the condenser and without regularity assumptions on the boundary of the condenser

Advances in fluorescent carbon dots for biomedical applications

Carbon Dots are an emerging class of carbon-based nanoparticles, which since their discovery have attracted tremendous attention because of their exceptional fluorescent, chemical and mechanical properties as well as high photostability and biocompatibility. This unique combination of outstanding characteristics, together with the ease with which they can be synthesized, qualify carbon dots as highly promising materials for applications in electronics and biology, in particular, for biosensing, bioimaging, biotherapy and drug delivery. In this review, we present some of the most recent applications of carbon dots in biology and medicine, concentrating on their fluorescence properties, biocompatibility and efficiency; we also discuss how improvements could prompt their use in human studies. We illustrate how carbon dots, prepared through several facile and cost-effective methods by either the bottom-up or the top-down route, can be used for imaging cells and bacteria and as sensing probes of metal cations. Moreover, we explain how their astonishing versatility has given rise to new biotherapy methods especially in the field of cancer theranostics

Cytokines and Other Mediators in Alopecia Areata

Alopecia areata, a disease of the hair follicles with multifactorial etiology and a strong component of autoimmune origin, has been extensively studied as far as the role of several cytokines is concerned. So far, IFN-γ, interleukins, TNF-α, are cytokines that are well known to play a major role in the pathogenesis of the disease, while several studies have shown that many more pathways exist. Among them, MIG, IP-10, BAFF, HLA antigens, MIG, as well as stress hormones are implicated in disease onset and activity. Within the scope of this paper, the authors attempt to shed light upon the complexity of alopecia areata underlying mechanisms and indicate pathways that may suggest future treatments

The experience of First Sexual Intercourse: an Exploratory Study in Greek Women

Background: A young person's first sexual intercourse is often a remarkable and memorable experience.However, little information exists regarding contextual factors of this first experience and the possible effects ontheir subsequent sexual lifeObjective: This study explored the conditions of and women’s emotional reactions to first sexual intercourse(FSI), as well as FSI’s impact on their future sexual experiences.Methodology: Participants were 899 women aged 19 to 40 yrs, registered in 23 arbitrarily selected GPs privatepractices. They completed a 30-item questionnaire regarding their first sexual intercourse experience.Results: It was found that information sources for sexual issues (family vs media) significantly influence both theadoption of responsible sexual behaviours and the formation of feelings preceding sexual initiation (p<0.05). Thestudy also demonstrated that even when FSI is perceived as voluntary other correlates (e.g. woman’s and /orpartner’s age, contraceptive use etc.) affect women’s emotional reaction to first coital experience and theirresponse to future sexual encounters.Conclusions: The findings of this study provide initial data to suggest that the first sexual intercourse experiencesignificantly impacts women’s sexual life. Health professionals should be aware of this information in thedevelopment of programs focusing on the promotion of sexual health for adolescents or parents; education

Left Ventricular Mass One Year After Radiofrequency Ablation for Atrial Fibrillation

Myxomas are the most common benign tumors of the heart. The exact etiology of myxomas is unknown and most cases are sporadic. It is well known though that myxomas can develop after cardiac trauma, and that radiofrequency ablation (RFA) for paroxysmal atrial fibrillation (PAF) increases the risk of thrombus or endocarditis in the atrium. The association of RFA and the formation of myxomas is not known. We report a case of a left ventricular myxoma in a patient after RFA

Laccase-Functionalized Graphene Oxide Assemblies as Efficient Nanobiocatalysts for Oxidation Reactions

Multi-layer graphene oxide-enzyme nanoassemblies were prepared through the multi-point covalent immobilization of laccase from Trametes versicolor (TvL) on functionalized graphene oxide (fGO). The catalytic properties of the fGO-TvL nanoassemblies were found to depend on the number of the graphene oxide-enzyme layers present in the nanostructure. The fGO-TvL nanoassemblies exhibit an enhanced thermal stability at 60 degrees C, as demonstrated by a 4.7-fold higher activity as compared to the free enzyme. The multi-layer graphene oxide-enzyme nanoassemblies can efficiently catalyze the oxidation of anthracene, as well as the decolorization of an industrial dye, pinacyanol chloride. These materials retained almost completely their decolorization activity after five reaction cycles, proving their potential as efficient nano- biocatalysts for various applications

Discovery of Novel Adenosine Receptor Antagonists through a Combined Structure- and Ligand-Based Approach Followed by Molecular Dynamics Investigation of Ligand Binding Mode

An intense effort is made by pharmaceutical and academic research laboratories to identify and develop selective antagonists for each adenosine receptor (AR) subtype as potential clinical candidates for "soft" treatment of various diseases. Crystal structures of subtypes A2A and A1ARs offer exciting opportunities for structure-based drug design. In the first part of the present work, Maybridge HitFinder library of 14400 compounds was utilized to apply a combination of structure-based against the crystal structure of A2AAR and ligand-based methodologies. The docking poses were rescored by CHARMM energy minimization and calculation of the desolvation energy using Poisson-Boltzmann equation electrostatics. Out of the eight selected and tested compounds, five were found positive hits (63% success). Although the project was initially focused on targeting A2AAR, the identified antagonists exhibited low micromolar or micromolar affinity against A2A/A3, ARs, or A3AR, respectively. Based on these results, 19 compounds characterized by novel chemotypes were purchased and tested. Sixteen of them were identified as AR antagonists with affinity toward combinations of the AR family isoforms (A2A/A3, A1/A3, A1/A2A/A3, and A3). The second part of this work involves the performance of hundreds of molecular dynamics (MD) simulations of complexes between the ARs and a total of 27 ligands to resolve the binding interactions of the active compounds, which were not achieved by docking calculations alone. This computational work allowed the prediction of stable and unstable complexes which agree with the experimental results of potent and inactive compounds, respectively. Of particular interest is that the 2-amino-thiophene-3-carboxamides, 3-acylamino-5-aryl-thiophene-2-carboxamides, and carbonyloxycarboximidamide derivatives were found to be selective and possess a micromolar to low micromolar affinity for the A3 receptor

One Complete and Seven Draft Genome Sequences of Subdivision 1 and 3 Acidobacteria Isolated from Soil.

We report eight genomes from representatives of the phylum Acidobacteria subdivisions 1 and 3, isolated from soils. The genome sizes range from 4.9 to 6.7 Mb. Genomic analysis reveals putative genes for low- and high-affinity respiratory oxygen reductases, high-affinity hydrogenases, and the capacity to use a diverse collection of carbohydrates