Влияние нитропруссида натрия на параметры электрической и сократительной активности гладкой мускулатуры нижнего пищеводного сфинктера

Investigations of electrical and contractile activities of lower esophageal sphincter unstriped muscles under sodium nitroprusside impact have been fulfilled by the method of double sucrose gap. Effect of nitric oxide donor on potassium and calcium membrane conductance has been evaluated, as well as the role of intracellular NO-synthase. Membrane hyperpolarization and contractile activity decrease during the use of sodium nitroprusside and L-NAME have been observed. Conclusion has been drawn of NO effect on potassium membrane conductance as well as of the possible effect on contractile proteins and activation of cAMP-dependent regulation of LES UM physiological functions.Методом двойного сахарозного мостика проведены исследования электрической и сократительной активности гладких мышц нижнего пищеводного сфинктера (НПС) при действии нитропруссида натрия. Оценено действие донора оксида азота NO на калиевую и кальциевую проводимость мембраны, роль внутриклеточной NO-синтазы. Наблюдалась гиперполяризация мембран и снижение сократительной активности при применении нитропруссида натрия и L-NAME. Сделан вывод о действии NO на калиевую проводимость мембран, а также о возможном действии на сократительные белки и активацию цАМФ-зависимого пути регуляции физиологических функций гладкомышечной клетки (ГМК) НПС

GSH 006-15+7: A local Galactic supershell featuring transition from HI emission to absorption

We report on the discovery of a new Galactic supershell, GSH 006-15+7, from the Galactic All Sky Survey data. Observed and derived properties are presented and we find that GSH 006-15+7 is one of the nearest physically large supershells known, with dimensions of ~ 780 x 520 pc at a distance of ~ 1.5 kpc. The shell wall appears in HI emission at b <~ -6.5 deg and in HI self-absorption (HISA) at b >~ -6.5 deg. We use this feature along with HISA diagnostics to estimate an optical depth of tau ~ 3, a spin temperature of ~ 40 K and a swept-up mass of M ~ 3e6 solar masses. We also investigate the origin of GSH 006-15+7, assessing the energy contribution of candidate powering sources and finding evidence in favour of a formation energy of ~ 1e52 ergs. We find that this structure provides evidence for the transfer of mass and energy from the Galactic disk into the halo.Comment: 12 pages, 8 figures, accepted for publication in MNRA