Charakterisierung der Interaktion von Dystroglycan mit Neurexin unter Einbeziehung der Wechselwirkungen mit weiteren Neurexin-Liganden

Neurexin (Nrxn) bindet über seine extrazelluläre Domäne an Dystroglycan (DAG). Über die Interaktion von Nrxn und DAG ist bisher wenig bekannt und die Auswirkungen auf den Nrxn-Neuroligin- (Nlgn-) Komplex sind unbeleuchtet. Mithilfe zielgerichteter Mutagenese und Ko-Sedimentationsstudien wurden die exakten Bindungsepitope von DAG auf den Nrxn-Domänen LNS2 und LNS6 bestimmt und gezeigt, dass DAG mit bekannten Nrxn-Liganden Neurexophilin (Nxph) und Nlgn konkurriert. DAG bindet ausschließlich an insert-freie LNS-Domänen. Unerwarteterweise behindert die DAG-Bindung an die LNS2 die Nlgn-Interaktion mit der LNS6 von Nrxn. Eine simultane Bindung von Nxph und DAG an Nrxn ist jedoch möglich. Die Expression von DAG und die verschiedenen Nrxn-splice-Varianten könnten die Ausbildung unterschiedlicher transsynaptischer Nrxn-Nlgn-Komplexe ermöglichen oder verhindern und so einen Mechanismus andeuten um die synaptische Identität in verschiedenen Entwicklungs- und Aktivitätszuständen zu bestimmen.<br/

Formation of iron nitride thin films with Al and Ti additives

In this work we investigate the process of iron nitride (Fe-N) phase formation using 2 at.% Al or 2 at.% Ti as additives. The samples were prepared with a magnetron sputtering technique using different amount of nitrogen during the deposition process. The nitrogen partial pressure (\pn) was varied between 0-50% (rest Argon) and the targets of pure Fe, [Fe+Ti] and [Fe+Al] were sputtered. The addition of small amount of Ti or Al results in improved soft-magnetic properties when sputtered using \pn $\leq$ 10\p. When \pn is increased to 50\p non-magnetic Fe-N phases are formed. We found that iron mononitride (FeN) phases (N at% $\sim$50) are formed with Al or Ti addition at \pn =50% whereas in absence of such addition \eFeN phases (N\pat$\sim$30) are formed. It was found that the overall nitrogen content can be increased significantly with Al or Ti additions. On the basis of obtained result we propose a mechanism describing formation of Fe-N phases Al and Ti additives.Comment: 9 Pages, 7 Figure

Fe and N self-diffusion in non-magnetic Fe:N

Fe and N self-diffusion in non-magnetic FeN has been studied using neutron reflectivity. The isotope labelled multilayers, FeN/57Fe:N and Fe:N/Fe:15N were prepared using magnetron sputtering. It was remarkable to observe that N diffusion was slower compared to Fe while the atomic size of Fe is larger compared to N. An attempt has been made to understand the diffusion of Fe and N in non-magnetic Fe:N

Surfactant induced smooth and symmetric interfaces in Cu/Co multilayers

In this work we studied Ag surfactant induced growth of Cu/Co multilayers. The Cu/Co multilayers were deposited using Ag surfactant by ion beam sputtering technique. It was found that Ag surfactant balances the asymmetry between the surface free energy of Cu and Co. As a result, the Co-on-Cu and Cu-on-Co interfaces become sharp and symmetric and thereby improve the thermal stability of the multilayer. On the basis of obtained results, a mechanism leading to symmetric and stable interfaces in Cu/Co multilayers is discussed.Comment: 7 Pages, 7 Figure

Lithium Transport through Ultrathin Silicon Layers

This contribution presents non-destructive measurements of lithium transport parameters (diffusivity, permeability) in nanometer sized silicon layers done by a novel neutron reflectometry (NR) based approach [4]

SDSS J212531.92–010745.9 : the first definite PG 1159 close binary system

Aims. The archival spectrum of SDSS J212531.92−010745.9 shows not only the typical signature of a PG 1159 star, but also indicates the presence of a companion. Our aim was the proof of the binary nature of this object and the determination of its orbital period. Methods. We performed time-series photometry of SDSS J212531.92−010745.9. We observed the object during 10 nights, spread over one month, with the Tübingen 80 cm and the Göttingen 50 cm telescopes. We fitted the observed light curve with a sine and simulated the light curve of this system with the nightfall program. Furthermore, we compared the spectrum of SDSS J212531.92−010745.9 with NLTE models, the results of which also constrain the light curve solution. Results. An orbital period of 6.95616(33) h with an amplitude of 0.354(3) mag is derived from our observations. A pulsation period could not be detected. For the PG 1159 star we found, as preliminary results from comparison with our NLTE models, T eff ∼ 90 000 K, log g ∼ 7.60, and the abundance ratio C/He ∼ 0.05 by number fraction. For the companion we obtained with a mean radius of 0.4 ± 0.1 R, a mass of 0.4 ± 0.1 M, and a temperature of 8200 K on the irradiated side, good agreement between the observed light curve and the nightfall simulation, but we do not regard those values as final

Multi-wavelength photometric variation of PG1605+072

In a large coordinated attempt to further our understanding of the $p$-mode pulsating sdB star PG1605+072, the Multi-Site Spectroscopic Telescope (MSST) collaboration has obtained simultaneous time-resolved spectroscopic and photometric observations. The photometry was extended by additional WET data which increased the time base. This contribution outlines the analysis of the MSST photometric light curve, including the four-colour BUSCA data from which chromatic amplitudes have been derived, as well as supplementary FUV spectra and light curves from two different epochs. These results have the potential to complement the interpretation of the published spectroscopic information.Comment: 6 pages, to be published in "Interpretation of asteroseismic data", proceedings of the HELAS NA5 Workshop, eds. W. Dziembowski, M. Breger and M. Thompson, Communications in Asteroseismology, 15