391 research outputs found
ATLAST detector needs for direct spectroscopic biosignature characterization in the visible and near-IR
Are we alone? Answering this ageless question will be a major focus for
astrophysics in coming decades. Our tools will include unprecedentedly large
UV-Optical-IR space telescopes working with advanced coronagraphs and
starshades. Yet, these facilities will not live up to their full potential
without better detectors than we have today. To inform detector development,
this paper provides an overview of visible and near-IR (VISIR;
) detector needs for the Advanced Technology
Large Aperture Space Telescope (ATLAST), specifically for spectroscopic
characterization of atmospheric biosignature gasses. We also provide a brief
status update on some promising detector technologies for meeting these needs
in the context of a passively cooled ATLAST.Comment: 8 pages, Presented 9 August 2015 at SPIE Optics + Photonics, San
Diego, C
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Demography, baseline disease characteristics and treatment history of patients with psoriasis enrolled in a multicentre, prospective, disease-based registry (PSOLAR)*
Summary Background: Psoriasis is associated with several comorbidities and behavioural risk factors. Objectives: To evaluate demographic and disease characteristics in patients enrolled in the Psoriasis Longitudinal Assessment and Registry (PSOLAR). Methods: PSOLAR is a global, prospective, longitudinal, disease-based registry that includes a postmarketing commitment to evaluate safety in patients with psoriasis. Enrolled patients had to be receiving, or be eligible to receive, conventional systemic or biological agents. Demographic/disease characteristics, medical histories, lifestyle risk factors and previous treatments are collected at enrolment. Efficacy and safety data are collected every 6 months for 8 years, and data are extracted annually. Selected parameters are evaluated by age quartile using post hoc analyses. Results: As of 23 August 2012, 11 900 patients were enrolled at 301 sites in North America, Europe and Latin America. Over half of the PSOLAR population (54·7%) is male, with a mean age of 48·6 years and mean body mass index of 30·9 kg m−2 at enrolment. Mean duration of disease at enrolment was 17·5 years, and mean Physician's Global Assessment score was 2·0. Psoriatic arthritis (35·5%) and cardiovascular diseases (38·2%) were highly prevalent. Diabetes mellitus type II was reported in 11·4% of patients. Depression and anxiety were noted in 14·7% and 11·1% of patients, respectively; 79·0% reported any alcohol use and 56·7% reported smoking or a history of smoking. The occurrence of most comorbidities, including cardiovascular disease and risk factors, increased with age. Conclusions: In the PSOLAR population, multiple and age-appropriate comorbidities are associated with psoriasis and may affect the selection of psoriasis treatments. What's already known about this topic? Psoriasis is a complicated disorder, often accompanied by multiple comorbidities. Demographic and disease characteristics of patients with psoriasis reported from large claims datasets may be affected by misclassification bias or coding errors. In clinical trials, many patients are excluded owing to strict inclusion criteria. What does this study add? Data collected by the Psoriasis Longitudinal Assessment and Registry reveal that the demographics and disease characteristics of patients with psoriasis who are receiving, or are candidates for, systemic therapy in actual clinical care resemble those reported in clinical trials. Most comorbidities occur more frequently in older patients, who, in turn, may require more comprehensive overall medical care
Dual Band Deep Ultraviolet AlGaN Photodetectors
We report on the design, fabrication and characterization of a back-illuminated voltage bias selectable dual-band AlGaN UV photodetector. The photodetector can separate UVA and W-B band radiation by bias switching a two terminal n-p-n homojunction structure that is fabricated in the same pixel. When a forward bias is applied between the top and bottom electrodes, the detector can sense UV-A and reject W-B band radiation. Alternatively, under reverse bias, the photodetector can sense UV-B and reject UV-A band radiation
A Finite Element Analysis of a Crack Penetrating or Deflecting into an Interface in a Thin Laminate
The crack tip driving force of a crack growing from a pre-crack that is perpendicular to and terminating at an interface between two materials is investigated using a linear fracture mechanics theory. The analysis is performed both for a crack penetrating the interface, growing straight ahead, and for a crack deflecting into the interface. The results from finite element calculations are compared with asymptotic solutions for infinitesimally small crack extensions. The solution is found to be accurate even for fairly large amounts of crack growth. Further, by comparing the crack tip driving force of the deflected crack with that of the penetrating crack, it is shown how to control the path of the crack by choosing the adhesion of the interface relative to the material toughness
On-Line Monitoring of Environment-Assisted Cracking in Nuclear Piping Using Array Probe Direct Current Potential Drop
A direct current potential drop method utilizing array probes with measurement ends maintaining an equalized potential designated as equi-potential switching array probe direct current potential drop (ESAP-DCPD) technique has been developed earlier at Seoul National University. This paper validates ESAP-DCPD technique by showing consistency among experimental measurements, analytical solution and numerical predictions using finite element analysis (FEA) of electric field changes with crack growth in metals. In order to examine its viability as an on-line monitoring of environment assisted crack growth at the inner surface of piping welds, artificial inner surface cracks were introduced in a full-scale weldment mockup pipe and stainless steel metal mockup pipe. The weldment was joined by low alloy steel and stainless steel pipes. The pipes were monitored by using ESAP-DCPD in laboratory environments. Optimization of electrical wiring configuration has produced results with significantly reduced noise for adequately long period of time. Then optimized experimental results were compared with the FEA prediction results for the mockup to show a good agreement. Also a round-robin measurement has been made at three laboratories. It has been found that the developed ESAP-DCPD can detect circumferential cracks with a depth of 40 % of wall thickness in stainless steel with a good detectability for further growth behaviors. For axial cracks, however, the measurements showed poor detectability. Hence the developed ESAP-DCPD system can be used to monitor large circumferential cracks that existing non-destructive examination techniques often fail to detect until leakage takes place.Korea (South). Ministry of Trade, Industry and Energy. Korea Institute of Energy Technology Evaluation and Plannin
A Microcalorimeter and Bolometer Model
The standard non-equilibrium theory of noise in ideal bolometers and
microcalorimeters fails to predict the performance of real devices due to
additional effects that become important at low temperature. In this paper we
extend the theory to include the most important of these effects, and find that
the performance of microcalorimeters operating at 60 mK can be quantitatively
predicted. We give a simple method for doing the necessary calculations,
borrowing the block diagram formalism from electronic control theory.Comment: 20 pages, 15 figure
Multipixel characterization of imaging CZT detectors for hard X-ray imaging and spectroscopy
We report our in-depth study of Cd-Zn-Te (CZT) crystals to determine an
optimum pixel and guard band configuration for Hard X-ray imaging and
spectroscopy. We tested 20x20x5mm crystals with 8x8 pixels on a 2.46mm pitch.
We have studied different types of cathode / anode contacts and different pixel
pad sizes. We present the measurements of leakage current as well as spectral
response for each pixel. Our I-V measurement setup is custom designed to allow
automated measurements of the I-V curves sequentially for all 64 pixels,
whereas the radiation properties measurement setup allows for interchangeable
crystals with the same XAIM3.2 ASIC readout from IDEAS. We have tested multiple
crystals of each type, and each crystal in different positions to measure the
variation between individual crystals and variation among the ASIC channels. We
also compare the same crystals with and without a grounded guard band deposited
on the crystal side walls vs. a floating guard band and compare results to
simulations. This study was carried out to find the optimum CZT crystal
configuration for prototype detectors for the proposed Black-Hole Finder
mission, EXIST.Comment: To appears in the SPIE 2004 proceedings (5540: Hard X-ray and
gamma-ray detector physics V
Correlation Between Bulk Material Defects and Spectroscopic Response in Cadmium Zinc Telluride Detectors
One of the critical challenges for large area cadmium zinc telluride (CdZnTe) detector arrays is obtaining material capable of uniform imaging and spectroscopic response. Two complementary nondestructive techniques for characterizing bulk CdZnTe have been developed to identify material with a uniform response. The first technique, infrared transmission imaging, allows for rapid visualization of bulk defects. The second technique, x-ray spectral mapping, provides a map of the material spectroscopic response when it is configured as a planar detector. The two techniques have been used to develop a correlation between bulk defect type and detector performance. The correlation allows for the use of infrared imaging to rapidly develop wafer mining maps. The mining of material free of detrimental defects has the potential to dramatically increase the yield and quality of large area CdZnTe detector arrays
Pan American interactions of Amazon precipitation, streamflow, and tree growth extremes
Rainfall and river levels in the Amazon are associated with significant precipitation anomalies of opposite sign in temperate North and South America, which is the dominant mode of precipitation variability in the Americas that often arises during extremes of the El Niño/Southern Oscillation (ENSO). This co-variability of precipitation extremes across the Americas is imprinted on tree growth and is detected when new tree-ring chronologies from the eastern equatorial Amazon are compared with hundreds of moisture-sensitive tree-ring chronologies in mid-latitude North and South America from 1759 to 2016. Pan-American co-variability exists even though the seasonality of precipitation and tree growth only partially overlaps between the Amazon and mid-latitudes because ENSO forcing of climate can persist for multiple seasons and can orchestrate a coherent response, even where the growing seasons are not fully synchronized. The tree-ring data indicate that the El Niño influence on inter-hemispheric precipitation and tree growth extremes has been strong and stable over the past 258-years, but the La Niña influence has been subject to large multi-decadal changes. These changes have implications for the dynamics and forecasting of hydroclimatic variability over the Americas and are supported by analyses of the available instrumental data and selected climate model simulations.Fil: Stahle, D.W.. University of Arkansas for Medical Sciences; Estados UnidosFil: Torbenson, Max Carl Arne. Ohio State University; Estados UnidosFil: Howard, I. M.. University of Arkansas for Medical Sciences; Estados UnidosFil: Granato Souza, D.. University of Arkansas for Medical Sciences; Estados UnidosFil: Barbosa, A. C.. Universidad Federal de Lavras; BrasilFil: Feng, S.. University of Arkansas for Medical Sciences; Estados UnidosFil: Schöngart, J.. National Institute For Amazon Research; BrasilFil: Lopez Callejas, Lidio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Villalba, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; ArgentinaFil: Villanueva, J.. Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias; MéxicoFil: Fernandes, K.. Columbia University; Estados Unido
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