Comparison of neonatal complications.

<p>WG: weeks of gestation; A/S: Affected/Survivors; <b>*</b> Inflammatory disease: Periventricular leukomalacia, and/or IVH and/or chronic lung disease and/or necrotizing enterocolitis and/or death.</p

Outcomes of 94 cases of PPROM before 24 WG.

<p>WG: Weeks of Gestation; EPPROM: Early Preterm Premature Rupture Of Membranes; NCIU: Neonatal Intensive Care Unit.</p

Comparison of neonatal criteria.

<p>SD: standard deviation; WG: weeks of gestation; gr: gram; ^<b>1</b> Difference of means, impact of rupture of membranes on the variable; * non interpretable.</p

Comparison of maternal, pregnancy and labour characteristics.

<p>SD: standard deviation; ^<b>1</b> Repetitive urinary or vaginal infections; ^<b>2</b> Uterus malformation, cervix insufficiency, conisation; ^<b>3</b> Interruption of pregnancy, C section, preterm birth; <b>*</b> non interpretable.</p

Comparison in Outcomes at Two-Years of Age of Very Preterm Infants Born in 2000, 2005 and 2010

<div><p>Objective</p><p>To investigate alteration in 2-year neurological/behavioral outcomes of very preterm infants born in a French level three neonatal intensive care unit.</p><p>Methods</p><p>We conducted a prospective, comparative study of very preterm infants born before 33 weeks’ gestation at 5-year intervals in 2000, 2005 and 2010 at Rouen University Hospital. Neonatal mortality/morbidities, ante- and neonatal treatments, and at age 2 years motor, cognitive and behavioral data were collected by standardized questionnaires.</p><p>Results</p><p>We included 536 very preterm infants. Follow-up rates at two years old were 78% in 2000, 93% in 2005 and 92% in 2010 respectively. No difference in gestational age, birthweight, neonatal mortality/morbidities was observed except a decrease in low grade subependymal/intraventricular hemorrhages. Care modifications concerned use of antenatal magnesium sulfate, breast-feeding and post-natal corticosteroid therapy. Significant improvement in motor outcome and dramatic decrease in cerebral palsy rates (12% in 2000, 6% in 2005, 1% in 2010, <i>p</i><0.001) were observed, as were improvements in feeding behavior. Although a non significant difference to better psychosocial behavior was reported, there was no difference in cognitive outcome.</p><p>Conclusions</p><p>Improvement in neuromotor outcome and behavior was reported. This could be due to multiple modifications in care: including administration of magnesium sulfate to women at risk of preterm birth, increase in breast-feeding, decrease in low grade subependymal/intraventricular hemorrhages, and decrease in post-natal corticosteroid therapy, all of which require further investigation in other studies. Extended follow-up until school age is mandatory for better detection of cognitive, learning and behavioral disorders.</p></div

Anthropometric data and parent’s level at 2 years of age.

<p>SD: Standard deviation</p><p>Anthropometric data and parent’s level at 2 years of age.</p

Outcomes at 2 years of age in the survivors of 2000, 2005 and 2010 cohorts.

<p>† Persistance difference between 2000 and 2010,</p><p>■ Persistance difference between 2000 and 2005</p><p>Outcomes at 2 years of age in the survivors of 2000, 2005 and 2010 cohorts.</p

Perinatal characteristics of 2000, 2005 and 2010 cohorts.

<p># Persistence difference between 2005 and 2010,</p><p>† Persistence difference between 2000 and 2010,</p><p>■ Persistence difference between 2000 and 2005SD: Standard deviation, PDA: patent ductus arteriosus</p><p>Perinatal characteristics of 2000, 2005 and 2010 cohorts.</p

Anthropometric data and parent’s level at 2 years of age.

<p>SD: Standard deviation</p><p>Anthropometric data and parent’s level at 2 years of age.</p

Flow chart of the study.

<p>Flow chart of the study.</p