A conceptual framework for developing explorative e-learning strategy using ontology-based knowledge management

This paper presents a conceptual framework for developing explorative e-learning strategy using ontology-based knowledge management. It conducts a comprehensive analysis of the applicability of ontologies in management of knowledge, with a particular reference to the development of explorative e-learning environments for enhancing an efficient use and reuse of available information and knowledge in e-learning, leading to a better understanding of the main issues for developing effective explorative e-learning strategies in an e-learning environment

From high-mass starless cores to high-mass protostellar objects

Aims: Our aim is to understand the evolutionary sequence of high-mass star formation from the earliest evolutionary stage of high-mass starless cores, via high-mass cores with embedded low- to intermediate-mass objects, to finally high-mass protostellar objects. Methods: Herschel far-infrared PACS and SPIRE observations are combined with existing data at longer and shorter wavelengths to characterize the spectral and physical evolution of massive star-forming regions. Results: The new Herschel images spectacularly show the evolution of the youngest and cold high-mass star-forming regions from mid-infrared shadows on the Wien-side of the spectral energy distribution (SED), via structures almost lost in the background emission around 100mum, to strong emission sources at the Rayleigh-Jeans tail. Fits of the SEDs for four exemplary regions covering evolutionary stages from high-mass starless cores to high-mass protostellar objects reveal that the youngest regions can be fitted by single-component black-bodies with temperatures on the order of 17K. More evolved regions show mid-infrared excess emission from an additional warmer component, which however barely contributes to the total luminosities for the youngest regions. Exceptionally low values of the ratio between bolometric and submm luminosity additionally support the youth of the infrared-dark sources. Conclusions: The Herschel observations reveal the spectral and physical properties of young high-mass star-forming regions in detail. The data clearly outline the evolutionary sequence in the images and SEDs. Future work on larger samples as well as incorporating full radiative transfer calculations will characterize the physical nature at the onset of massive star formation in even more depth.Comment: 4 pages, A&A Herschel special issu

A Generative-Discriminative Basis Learning Framework to Predict Clinical Severity from Resting State Functional MRI Data

We propose a matrix factorization technique that decomposes the resting state fMRI (rs-fMRI) correlation matrices for a patient population into a sparse set of representative subnetworks, as modeled by rank one outer products. The subnetworks are combined using patient specific non-negative coefficients; these coefficients are also used to model, and subsequently predict the clinical severity of a given patient via a linear regression. Our generative-discriminative framework is able to exploit the structure of rs-fMRI correlation matrices to capture group level effects, while simultaneously accounting for patient variability. We employ ten fold cross validation to demonstrate the predictive power of our model on a cohort of fifty eight patients diagnosed with Autism Spectrum Disorder. Our method outperforms classical semi-supervised frameworks, which perform dimensionality reduction on the correlation features followed by non-linear regression to predict the clinical scores

Hot Core, Outflows and Magnetic Fields in W43-MM1 (G30.79 FIR 10)

We present submillimeter spectral line and dust continuum polarization observations of a remarkable hot core and multiple outflows in the high-mass star-forming region W43-MM1 (G30.79 FIR 10), obtained using the Submillimeter Array (SMA). A temperature of $\sim$ 400 K is estimated for the hot-core using CH$_3$CN (J=19-18) lines, with detections of 11 K-ladder components. The high temperature and the mass estimates for the outflows indicate high-mass star-formation. The continuum polarization pattern shows an ordered distribution, and its orientation over the main outflow appears aligned to the outflow. The derived magnetic field indicates slightly super-critical conditions. While the magnetic and outflow energies are comparable, the B-field orientation appears to have changed from parsec scales to $\sim$ 0.1 pc scales during the core/star-formation process.Comment: accepted, ApJ Letter

High Mass Starless Cores

We report the identification of a sample of potential High-Mass Starless Cores (HMSCs). The cores were discovered by comparing images of the fields containing candidate High-Mass Protostellar Objects (HMPOs) at 1.2mm and mid-infrared (8.3um; MIR) wavelengths. While the HMPOs are detected at both wavelengths, several cores emitting at 1.2mm in the same fields show absorption or no emission at the MIR wavelength. We argue that the absorption is caused by cold dust. The estimated masses of a few 10^2Msun - 10^3 Msun and the lack of IR emission suggests that they may be massive cold cores in a pre-stellar phase, which could presumably form massive stars eventually. Ammonia (1,1) and (2,2) observations of the cores indicate smaller velocity dispersions and lower rotation temperatures compared to HMPOs and UCHII regions suggesting a quiescent pre-stellar stage. We propose that these newly discovered cores are good candidates for the HMSC stage in high-mass star-formation. This sample of cores will allow us to study the high-mass star and cluster formation processes at the earliest evolutionary stages.Comment: 7 pages, 3 figures, 1 table, to be published in ApJL, author names replaced with comma separatio

Application of medical gases in the field of neurobiology

Medical gases are pharmaceutical molecules which offer solutions to a wide array of medical needs. This can range from use in burn and stroke victims to hypoxia therapy in children. More specifically however, gases such as oxygen, helium, xenon, and hydrogen have recently come under increased exploration for their potential theraputic use with various brain disease states including hypoxia-ischemia, cerebral hemorrhages, and traumatic brain injuries. As a result, this article will review the various advances in medical gas research and discuss the potential therapeutic applications and mechanisms with regards to the field of neurobiology

SMA outflow/disk studies in the massive star-forming region IRAS18089-1732

SMA observations of the massive star-forming region IRAS 18089-1732 in the 1mm and 850mu band reveal outflow and disk signatures in different molecular lines. The SiO(5--4) data show a collimated outflow in the northern direction. In contrast, the HCOOCH3(20--19) line, which traces high-density gas, is confined to the very center of the region and shows a velocity gradient across the core. The HCOOCH3 velocity gradient is not exactly perpendicular to the outflow axis but between an assumed disk plane and the outflow axis. We interpret these HCOOCH3 features as originating from a rotating disk that is influenced by the outflow and infall. Based on the (sub-)mm continuum emission, the mass of the central core is estimated to be around 38M_sun. The dynamical mass derived from the HCOOCH3 data is 22Msun, of about the same order as the core mass. Thus, the mass of the protostar/disk/envelope system is dominated by its disk and envelope. The two frequency continuum data of the core indicate a low dust opacity index beta ~ 1.2 in the outer part, decreasing to beta ~ 0.5 on shorter spatial scales.Comment: 7 pages of text, 1 table, 3 figures, accepted for ApJ Letter

Submillimeter Array multiline observations of the massive star-forming region IRAS 18089-1732

Submillimeter Array (SMA) observations of the high-mass star-forming region IRAS 18089-1732 in the 1 mm and 850 $\mu$m band with 1 GHz bandwidth reveal a wealth of information. We present the observations of 34 lines from 16 different molecular species. Most molecular line maps show significant contributions from the outflow, and only few molecules are confined to the inner core. We present and discuss the molecular line observations and outline the unique capabilities of the SMA for future imaging line surveys at high spatial resolution.Comment: Accepted for ApJ Letters, SMA special volum