Evaluations of a Mechanistic Hypothesis for the Influence of Extracellular Ions on Electroporation Due to High-Intensity, Nanosecond Pulsing

The effect of ions present in the extracellular medium on electroporation by high-intensity, short-duration pulsing is studied through molecular dynamic simulations. Our simulation results indicate that mobile ions in the medium might play a role in creating stronger local electric fields across membranes that then reinforce and strengthen electroporation. Much faster pore formation is predicted in higher conductivity media. However, the impact of extracellular conductivity on cellular inflows, which depend on transport processes such as electrophoresis, could be different as discussed here. Our simulation results also show that interactions between cations (Na+ in this case) and the carbonyl oxygen of the lipid headgroups could impede pore resealing

Bounds on Energy and Laplacian Energy of Graphs

Let G be simple graph with n vertices and m edges. The energy E(G) of G, denotedby E(G), is dened to be the sum of the absolute values of the eigenvalues of G. Inthis paper, we present two new upper bounds for energy of a graph, one in terms ofm,n and another in terms of largest absolute eigenvalue and the smallest absoluteeigenvalue. The paper also contains upper bounds for Laplacian energy of graph

Awareness of Web 3.0 Technology among the Researchers and Faculty member of Medical, Rajiv Gandhi University of health science: A Study

Abstract This paper depicts the Awareness of web 3.0 utilized as a part of Medical Faculty Members and Researchers condition in Rajiv Gandhi University of Health science. We have just observed our administrations and accumulations change drastically with the ascent of the web and everything that it has carried with it, from the coordination’s of offering open web access, to e-assets, Web 2.0 and the utilization of the semantic web. The Social networking sites (SNSs) have permeated our daily lives. As social media usage with mobile devices such as smart phones and tablet devices increases, it has gained attention to communicate in emergency situations such as natural disasters. Moreover, many researchers consider Social Networking Sites as promising tools for gathering information to find the solutions of contemporary issues

Monte Carlo Analysis of GaN-Based Gunn Oscillators for Microwave Power Generation

Monte Carlo studies of transferred electron oscillators based on bulk wurtzite GaN are presented. Two structures have been examined: (i) devices with the conventional single notch structure, and (ii) repetitive structures with serial segments to fashion a multiple domain device. Wurtzite material has been chosen because of the higher drift velocity and because analytical expressions for the band structure have recently become available. Performance parameters of interest such as the operating frequency, output power, and conversion efficiency are calculated. Variations due to changes in temperature, biasing voltage, and device length are also included. It is shown that multidomain Gunn diodes can lead to significant improvements in output power over conventional, single-transit structure, and so such multiple GaN diodes merit serious experimental study

Effect of Integrated Nutrient Management on Onion Yield and Soil Properties under Chromic haplusterts of Karnataka

A field experiment was conducted during the Kharif season of 2002 and 2003 under Chromic Haplusterts (medium black soils) at Zonal Agricultural Research Station, Hiriyur to study the effect of Coir Pith Based Compost (CPBC) along with organic manures and inorganic fertilizers on yield of Onion. The study revealed that combined application of CPBC @ 15 t/ha along with press mud (PM) and half the recommended dose of fertilizer (RDF) gave significant higher bulb yield of onion (14.70 t/ha) as compared to RDF along with FYM (9.55 t/ha). The bulb yields were on par with the combined application of CPBC along with FYM and 50% RDF or combined application of CPBC and Green manure (GM) along with 100% RDF, indicating the utility of CPBC in onion cultivation. Higher net and gross returns were recorded with application of CPBC and PM @ 15 t/ha each along with 50% RDF with better benefit cost ratio. The yield and quality parameters also differed significantly among the various combinations of CPBC with PM or FYM in conjunction with inorganic fertilizers. Analysis of the soil after the harvest of onion crop did not show any significant difference in pH and EC among the treatments. However, organic carbon, available phosphorus and available potash were significantly higher due to application of CPBC, PM, FYM and GM along with 50% or 100% RDF

Simulations of Intracellular Calcium Release Dynamics in Response to a High-Intensity, Ultrashort Electric Pulse

Numerical simulations for electrically induced, intracellular calcium release from the endoplasmic reticulum are reported. A two-step model is used for self-consistency. Distributed electrical circuit representation coupled with the Smoluchowski equation yields the ER membrane nanoporation for calcium outflow based on a numerical simulation. This is combined with the continuum Li-Rinzel model and drift diffusion for calcium dynamics. Our results are shown to be in agreement with reported calcium release data. A modest increase (rough doubling) of the cellular calcium is predicted in the absence of extra-cellular calcium. In particular, the applied field of 15 kV/cm with 60 ns pulse duration makes for a strong comparison. No oscillations are predicted and the net recovery period of about 5 min are both in agreement with published experimental results. A quantitative explanation for the lack of such oscillatory behavior, based on the density dependent calcium fluxes, is also provided

Influence of Heat Input, Working Fluid and Evacuation Level on the Performance of Pulsating Heat Pipe

An experimental study on pulsating heat pipe (PHP) is presented in this work. A closed loop PHP with a single U turn is fabricated and tested. The transient and steady state experiments are conducted and operating temperatures are measured. The experiments are carried out for different working fluids, heat input and for different evacuation levels. The derived parameters include thermal resistance and heat transfer coefficient of PHP. The results of these experiments show an intermittent motion of the working fluid at lower heat input. The temperature difference between evaporator and condenser at steady state is found lower for acetone compared to water, ethanol and methanol. Lower value of thermal resistance and higher value of heat transfer coefficient are observed in case of acetone compared to water, ethanol and methanol. Lower values of temperature difference between evaporator and condenser and thermal resistance and higher value of heat transfer coefficient are observed at atmospheric conditions of operation of PHP compared to evacuation conditions. The Power Spectral Density Analysis is also carried out on the results of these experiments using FFT technique to analyse the pulsating motion of the fluid in a PHP. In the Power Spectral Density analysis, the frequency distribution of temperature variation in PHP was observed over a wider range, signifying the periodic motion in the fluid flow of the liquid slug and vapour plug. This characteristic frequency corresponded to the characteristic time for a couple of adjacent vapour plug and liquid slug passing through a specific local wall surface in a PHP