Total Quality Management Practices and Technology Transfer in Malaysian Public University

It is widely accepted that the implementation of Total Quality Management (TQM) as a management philosophy has significantly contributed to good management practice in business organization particularly in the manufacturing and service sectors. The applications of that concepts, techniques and tools have been successfully tailored to non-profit service or government-based organization. In the context of higher education institution, it has been seriously debated by the TQM scholars and academicians on the issue of to what extent TQM can be applied and how relevant its practices are to higher education\u27s core business i.e. teaching and research. Despite having sufficient knowledge and research on TQM implementation in the scope of manufacturing practices and administration-related services, it is hard to find a research on TQM, which focuses on the scope of R&D at a university. This gap has to be filled because the management of research is a critical topic for universities worldwide. For developing countries such as Malaysia the need to have good management practice in R&D is even greater. Without effective research management, the task of becoming significant players in the global knowledge market will become harder. Thus, the first part of this paper will discuss the applicability of TQM and propose a theoretical framework or model of TQM to suit the need of R&D context. The constructs for the TQM framework are based on previous empirical studies and the evaluation criteria of world standard criteria such as MBNQA, EFQM, and QMS ISO 9000. The TQM constructs that will be proposed are leadership, strategic planning, student/stakeholder & industry focus, data & information management, staff management, process & system approach, partnership & resource and continuous improvement. The second part of the paper will discuss the performance indicators of R&D activities particularly in the context of public university. The review of International literatures stressed that the performance of R&D activities have to be measured. The current issue related to research performance at university is the level the research output that can be transferred to the stakeholders. Therefore, this study will use technology transfer framework to measure research performance such as publication, patents, royalty and Spin-off Company. Finally, this paper will conceptually develop a model that would show the relationship between the TQM practices in the area of research and the level of technology transfer

Stimulatory effects of egg-laying hormone and gonadotropin-releasing hormone on reproduction of the tropical abalone, Haliotis asinina linnaeus

Egg-laying hormone (ELH) is a neuropeptide hormone that stimulates ovulation of gastropods, including Aplysia californica and Lymnaea stagnalis. Other neuropeptides, gonadotropin releasing hormones (GnRHs), also play important roles in controlling reproduction in both vertebrates and invertebrates. In the current study, the effects of abalone ELH (aELH) and several GnRHs on somatic growth, sex differentiation, gonad maturation, and spawning of Haliotis asinina were investigated in 3 experiments. In experiment 1, groups of 4-mo-old juveniles (11.8&nbsp;&plusmn;&nbsp; 0.03 mm shell length (SL) and 0.33&nbsp;&plusmn; 0.04 g body weight (BW)) were injected with aELH and GnRHs, including buserelin (mammalian GnRH analogue), octopus GnRH (octGnRH), and tunicate GnRH-I (tGnRH-I), at doses of 20 ng/g BW and 200 ng/g BW. The aELH induced early sex differentiation with a bias toward females, but with normal somatic growth, whereas the different isoforms of GnRH had no effect on sexual differentiation or somatic growth. In experiment 2, groups of 1-y-old-abalone (SL, 4.04&nbsp;&plusmn; 0.02 cm; BW, 20.15&nbsp;&plusmn;&nbsp;0.25 g) were injected with aELH and the 3 isoforms of GnRH including buserelin, octGnRH, and lamprey GnRH (1GnRH-I) at doses of 500 ng/g BW and 1,000 ng/g BW, and all produced stimulatory effects. For each peptide treatment, the gonads reached full maturation within 5- 6 wk and spawning occurred, whereas control groups took 8 wk to reach maturity. In experiment 3, injections of ripe abalone with aELH stimulated spawning of both sexes in a dose-dependent manner. Buserelin had a lesser effect on inducing spawning, and octGnRH had no apparent effect. The gametes released from induced spawnings by aELH and GnRH showed normal fertilization and development of larvae. Altogether, these findings provide further knowledge on manipulating abalone reproduction, which is important in improving abalone aquaculture.<br /

The existence of gonadotropin-releasing hormone-like peptides in the neural ganglia and ovary of the abalone, Haliotis asinina L.

Gonadotropin-releasing hormone (GnRH) is a neuropeptide that is conserved in both vertebrate and invertebrate species. In this study, we have demonstrated the presence and distribution of two isoforms of GnRH-like peptides in neural ganglia and ovary of reproductively mature female abalone, Haliotis asinina, using immunohistochemistry. We found significant immunoreactivities (ir) of anti-lamprey(I) GnRH-III and anti-tunicate(t) GnRH, but with variation of labeling intensity by each anti-GnRH type. IGnRH-III-ir was detected in numerous type1 neurosecretory cells (NS1) throughout the cerebral and pleuropedal ganglia, whereas tGnRH-I-ir was detected in only a few NS1 cells in the dorsal region of cerebral and pleuropedal ganglia. In addition, a small number of type2 neurosecretory cells (NS2) in cerebral ganglion showed lGnRH-III-ir. Long nerve fibers in the neuropil of ventral regions of the cerebral and pleuropedal ganglia showed strong tGnRH-I-ir. In the ovary, lGnRH-III-ir was found primarily in oogonia and stage I oocytes, whereas tGnRH-ir was observed in stage I oocytes and some stage II oocytes. These results indicate that GnRH produced in neural ganglia may act in neural signaling. Alternatively, GnRH may also be synthesized locally in the ovary where it could induce oocytes development

Identification of an attractin-like pheromone in the mucus-secreting hypobranchial gland of the abalone Haliotis asinina linnaeus.

Pheromones are chemicals used to communicate between animals of the same species, and are thought to be used by most marine animals. With limited vision, abalone primarily sense their world chemically, and pheromones may play an important role in settlement, attraction, recognition, alarm, and reproduction. Despite this, there has been no detailed investigation into pheromone substances, both in their precise biochemical nature or pheromonal function. In this study, we investigated the presence of pheromonelike substances from the hypobranchial gland of the abalone Haliotis asinina using bioassays, immunohistochemistry, Western blotting, and reverse-phase high-performance liquid chromatography (RP-HPLC). The hypobranchial gland of many prosobranchial marine molluscs has been classified as a sex auxiliary gland releasing unknown substances during spawning. In our study, cephalic tentacle assays demonstrated that the cell extracts of the hypobranchial gland contain chemical cues that are sensed by conspecifics. An antibody against the sea slug &ldquo;attractin&rdquo; pheromone was used as a probe to localize a similar protein in the mucin-secreting cells of the epithelial lining the hypobranchial gland of both male and female abalone. The approximate molecular weight of this abalone attractin-like protein is 30 kDa in both males and females. Fractionation of hypobranchial gland extracts by C5 RP-HPLC could not selectively purify this protein, and no sex-specific differences were observed. We predict that the attractin-like protein could be one of a number of important proteins involved in maturation, aggregation, and/or spawning behavior of abalone. In future research, additional hypobranchial gland components will be tested further for these types of behavior

The effects of biogenic amines, gonadotropin-releasing hormones and corazonin on spermatogenesis in sexually mature small giant freshwater prawns, Macrobrachium rosenbergii (De Man, 1879)

Neurotransmitters such as the serotonin (5-HT) and dopamine (DA), as well as the neurohormones gonadotropin-releasing hormones (GnRHs) and corazonin (Crz), are known to have various effects on decapod crustaceans, including ovarian maturation and spermatogenesis. The effects of these neurotransmitters and neurohormones on spermatogenesis in the small male freshwater prawns, Macrobrachium rosenbergii, have not been reported. So, we undertook histological and histochemical observations, as well as germ cell proliferation assays to examine the effects of 5-HT, DA, two exogenous GnRH isoforms (l-GnRH-III and oct-GnRH) and Crz. Ten experimental groups were injected with 5-HT and DA at 2.5 × 10−7 and 2.5 × 10−6 mol/prawn, and l-GnRH-III, oct-GnRH and Crz at 50 and 500 ng/gBW, at 4-day intervals from days 0 to 16. We found that prawns treated with 5-HT and GnRH isoforms exhibited significant increases in their testis-somatic index (TSI), seminiferous tubules at early maturation, i.e., stages I and III, with increased diameter of the tubules (DST), and germ cell proliferation, by days 4, 12 and 16, compared with saline control groups. In contrast, prawns treated with DA and Crz showed mostly seminiferous tubules at late maturation stages VIII and IX, and decreases of TSI, DST, and cell proliferation, by day 12, compared with saline control groups. By day 16 the Crz-treated prawns had died. These data indicate that 5-HT and GnRHs can stimulate spermatogenesis, while DA and Crz inhibit spermatogenesis. Consequently, hormonal treatment of male broodstocks in aquaculture with 5-HT and GnRHs could provide valuable tools to enhance reproduction by accelerating testicular maturation, leading to increased production of sperm

Tissue-specific expression of <i>Macrobrachium rosenbergii</i> neuropeptide genes, using RT-PCR.

<p>Expression of 11 neuropeptide genes using gene-specific primers, as well as the β-actin gene. PCR used cDNA derived from 13 tissues of female (including 4 stages of ovarian tissue) and 1 tissue of male (testis). Negative control represents no cDNA in PCR. CCAP, Crustacean cardioactive peptide; CLDH, Calcitonin-like diuretic hormone; EH, Eclosion hormone; NPF, Neuropeptide F; SK, Sulfakinin; SIF, SIFamide; NP, Neuroparsin.</p