Copyright Protection for Works in the Language of Life

In 2001, the DNA Copyright Institute sought to capitalize on the fear of human cloning by offering celebrities the opportunity to use copyright to secure exclusive rights in their DNA. At the time, a Copyright Office spokesperson pointed out that a person’s DNA “is not an original work of authorship.” That statement is no longer self-evident. A scientist claims to have used CRISPR technology to create a pair of twin girls with human-altered DNA that may provide immunity to HIV infection and improved cognitive function. Through gene therapy, doctors can “author” changes to patients’ DNA to cure disease. Scientists “edit” bacterial cell DNA to produce medicines and industrial enzymes. Researchers have “written” original DNA encoding a GIF of a running horse. Does copyright grant exclusive rights to these creations? For decades, scholars have argued that DNA sequences, like computer programs, are copyrightable “works” encompassed by the Copyright Act’s definition of “literary works.” So far, the Copyright Office is unconvinced and continues to list DNA sequences and compounds as “works” that do not constitute copyrightable subject matter. This Article takes a new approach by proposing that DNA is not a “work” at all. Rather, DNA is a medium in which information is stored. In the words of the Copyright Act, DNA compounds are “copies” in which an original copyrightable work or a functional creation may be fixed. Under this framework, literature is entitled to copyright protection whether it exists as a copy printed on paper or encoded into DNA. Genetic DNA, which functions as a component of cellular machinery to produce useful chemicals, is entitled to no more copyright protection any other machine component. Rejecting this approach and continuing to treat DNA as a “work” rather than a “copy” has real world consequences. The recent history of copyright protection for computer programs provides a cautionary tale. Mischaracterizing DNA in the way that computer programs have been mischaracterized – as a type of “work” under the Copyright Act – could lead to the extension of exclusive copyrights to the functional DNA in living organisms in the same way that copyright protection has been extended to some functional aspects of computer programs

Copyright Protection for Works in the Language of Life

In 2001, the DNA Copyright Institute sought to capitalize on the fear of human cloning by offering celebrities the opportunity to use copyright to secure exclusive rights in their DNA. At the time, a Copyright Office spokesperson pointed out that a person’s DNA “is not an original work of authorship.” That statement is no longer self-evident. A scientist claims to have used CRISPR technology to create a pair of twin girls with human-altered DNA that may provide immunity to HIV infection and improved cognitive function. Through gene therapy, doctors can “author” changes to patients’ DNA to cure disease. Scientists “edit” bacterial cell DNA to produce medicines and industrial enzymes. Researchers have “written” original DNA encoding a GIF of a running horse. Does copyright grant exclusive rights to these creations? For decades, scholars have argued that DNA sequences, like computer programs, are copyrightable “works” encompassed by the Copyright Act’s definition of “literary works.” So far, the Copyright Office is unconvinced and continues to list DNA sequences and compounds as “works” that do not constitute copyrightable subject matter. This Article takes a new approach by proposing that DNA is not a “work” at all. Rather, DNA is a medium in which information is stored. In the words of the Copyright Act, DNA compounds are “copies” in which an original copyrightable work or a functional creation may be fixed. Under this framework, literature is entitled to copyright protection whether it exists as a copy printed on paper or encoded into DNA. Genetic DNA, which functions as a component of cellular machinery to produce useful chemicals, is entitled to no more copyright protection than any other machine component. Rejecting this approach and continuing to treat DNA as a “work” rather than a “copy” has real world consequences. The recent history of copyright protection for computer programs provides a cautionary tale. Mischaracterizing DNA in the way that computer programs have been mischaracterized — as a type of “work” under the Copyright Act — could lead to the extension of exclusive copyrights to the functional DNA in living organisms in the same way that copyright protection has been extended to some functional aspects of computer programs

Session 3: Diversity Enhancing Intellectual Property

The field of intellectual property suffers from a lack of diversity. Women are underrepresented as credited inventors in the United States. Additionally, multi-gender inventor groups are underrepresented compared to all-male and, sometimes, even all-female groups. This representation has changed over time, with changes not always reflecting an increase in female representation. This is particularly true when studying gender-disparity as it exists in the field of computer programming and software patents. While women were well represented in computer programming at field’s inception, this changed after World War II because men lobbied to push women out of the field. Women have since been erased from the history of computer programming and have not been recognized for their contributions to the field

The effects of direct red bull administration to isolated hearts of trained and untrained rats who regularly consumed or did not consume energy drink: Focus on cardiodynamics and oxidative stress

Energy drinks (EDs) contain caffeine and other active ingredients which affect cardiovascular system. The aims of this study were to examine direct effects of Red Bull (RB) on cardiodynamics and oxidative stress in isolated hearts of rats. The rats were divided into four groups: Untrained rats who never consumed ED (dEDUT); untrained rats who consumed ED 5 days a week during 4 weeks (ch+dED-UT); rats trained 5 times a week for 4 weeks, but did not consume ED (dED-T); rats trained and consumed ED 5 times a week for 4 weeks (ch+dED-T). After sacrificing, hearts were isolated and perfused according to Langendorff technique. Through the isolated heart of all rats in each group, RB was administered. The parameters of cardiac function were recorded, and the levels of prooxidants were measured in the coronary effluent during coronary autoregulation. Rats in ch+dED-UT group had significantly lower rates of myocardial contraction and relaxation compared to rats in dED-UT group. The same effect was recorded in the dED-T group compared to dED-UT group. The levels of hydrogen peroxide were significantly higher in trained rats. Rats in ch+dED-T group also had significantly higher levels of superoxide anion radical and index of lipid peroxidation, as well as lower levels of nitrites when compared to ch+dED-UT group, while opposite effect was recorded in rats in dED-T group compared to dEDUT group. The RB could have a potentially negative inotropic effect in chronic consumers. Prooxidative effect of RB was most pronounced in trained chronic consumers

Acute effects of nandrolone decanoate on oxidative stress in isolated rat heart

Abuse of anabolic-androgenic steroids (AAS) produces side effects in different tissues, with oxidative stress linked to their pathophysiology, being involved in fibrosis, cellular proliferation, and tumorigenesis. The aim of this study was to examine the acute effects of nandrolone decanoate (ND) on oxidative stress in isolated rat heart. The hearts of male Wistar albino were excised and perfused according to the Langendorff technique at gradually increasing coronary perfusion pressures (40-120 cm H2O). The hearts were perfused with ND at doses of 1, 10 and 100 μM. Oxidative stress markers, including the index of lipid peroxidation (thiobarbituric acid reactive substances (TBARS)), nitric oxide (nitrites; NO2-), the superoxide anion radical (O2-) and hydrogen peroxide (H2O2) were measured in the coronary venous effluent. Our results showed that acute effects of ND do not promote the production of reactive oxygen species (ROS). Our finding pointed out that the highest concentration of ND may even possess some anti-oxidative potential, which should be examined further

The role of hydrogen sulfide in homocysteine-induced cardiodynamic effects and oxidative stress markers in the isolated rat heart

This study aimed to assess the role of H2S in homocysteine-induced cardiodynamic effects in the isolated rat heart. The hearts were retrogradely perfused according to the Langendorff technique. The maximum and minimum rates of pressure in the left ventricle (dp/dt max, dp/dt min), systolic and diastolic left ventricular pressures (SLVP, DLVP), heart rate (HR), and coronary flow (CF) were measured. A spectrophotometrical method was used to measure the following oxidative stress markers: index of lipid peroxidation (thiobarbituric acid reactive substances, TBARS), nitrite level (NO2−), superoxide anion radicals (O2•−), and hydrogen peroxide (H2O2) concentrations. The administration of 10 µmol/l DL-homocysteine (DL-Hcy) alone decreased dp/dt max, SLVP, and CF but did not change any oxidative stress parameters. The administration of 10 µmol/l DL-propargylglycine (DL-PAG) decreased all cardiodynamic parameters and increased the concentration of O2•−. The co-administration of DL-Hcy and DL-PAG induced a significant decrease in all estimated cardiodynamic parameters and decreased the concentration of NO2− and O2•− but increased the levels of TBARS and H2O2. Homocysteine shows a lower pro-oxidative effect in the presence of hydrogen sulfide (H2S), which indicates a potential anti-oxidative capacity of H2S