I marchi nel mondo reale e nel ciberspazio: profili di diritto del commercio internazionale

Dottorato di ricerca in diritto internazionale. 12. ciclo. Relatori Andrea Comba e Alberto Santa Maria. Coordinatore Franco MosconiConsiglio Nazionale delle Ricerche - Biblioteca Centrale - P.le Aldo Moro, 7, Rome; Biblioteca Nazionale Centrale - Piazza Cavalleggeri, 1, Florence / CNR - Consiglio Nazionale delle RichercheSIGLEITItal

Nome e identità femminile nel mondo antico

Il volume, che inaugura la collana LINGUISTICA DELLE DIFFERENZE, raccoglie contributi dedicati al nome e all'identità femminile, con particolare attenzione alle modalità con cui, attraverso lo strumento linguistico e nell'ambito del testo letterario, storico e filosofico, si viene delinando l'identità linguistica e culturale della donna nell'antichità classica, momento fondativo per la costruzione dei saperi sui quali tuttora si fonda la nostra civiltà occidentale. I contributi e il dibattito scientifico che ne è scaturito sono il frutto delle attività promosse nell'ambito di un Accordo Internazionale tra l'Università Federico II di Napoli e l'Universidad Metropolitana de Cinencias de la Educación di Santiago del Cile, dirette ad approfondire e rinnovare, attraverso la riflessione sul pensiero antico, tematiche ancora oggi attualissime e di fondamentale importanza per la promozione di spazi di interscambio, confronto e integrazione, indispensabili allo stabilirsi di una solida cultura della pace. Contributi di Grazia Basile, Francesca Chiusaroli, Francesca M. Dovetto, Rodrigo Frías Urrea, Simona Leonardi, Victor Hugo Méndez, Lidia Palumbo, Massimo Peri, Mauro Serra, Domenico Silvestri, Marisa Squillante, Guglielmo Trupiano, Cristina Vallini. Francesca M. Dovetto insegna Glottologia e linguistica all'Università di Napoli Federico II. Si interessa di storia del pensiero linguistico, di lessico e edi etimologia, degli aspetti connotativi della comunicazione linguistica con particolare riferimento alla linguistica delle 'differenze'. Rodrigo Frías Urrea insegna Filosofía Antigua nel Centro de Estudios Clásicos Giuseppina Grammatico Amari della Universidad Metropolitana de Ciencias de la Educación di Santiago del Cile, ed Etica nella Pontificia Universidad Católica de Chile. Si interessa di filosofía antica e della sua influenza sulla riflessione filosofica di epoca più tarda, con particolare riguardo per l'età contemporanea, così come di etica e bioetica

Frequency and clinical features of GBA mutations in Italian patients with Parkinson disease

Biallelic mutations in the Glucocerebrosidase gene (GBA) cause autosomal recessive Gaucher Disease. More recently, heterozygous rare variants of GBA have been consistently associated with increased risk to develop Parkinson Disease (PD) and Lewy Body Dementia (LBD). All exons and exon/intron boundaries of GBA gene were sequenced in familial and sporadic patients with early onset parkinsonism (EOP, 130), PD (408) and LBD (70) from Central-Southern Italy. GBA mutations were detected in 71/608 probands (11,68%; 27 EOP, 39 PD and 5 LBD), all but five in heterozygous state. Among homozygous patients (2 EOP, 1 PD and 1 LBD), none had features of Gaucher features. Overall, 27 distinct mutations were identified. The two recurrent mutations L444P and N370S overall accounted only for less than 40% of mutated cases (15/71, 21%, and 13/71, 18% respectively). A third mutation, E326K, was also common (10/71, 14%), while three mutations (p.G232R, p.C381F and p.M400Lfs*2) were novel. No specific genotype-phenotype correlations emerged. Frequencies of mutation carriers were 7,1% among LBD, 9,6% among PD and up to 20,8% among EOP patients. In fact, 38% of GBA mutation carriers had a diagnosis of EOP. Among PD and EOP patients, non-motor signs, such as cognitive impairment, psychiatric and autonomic dysfunctions were more frequently reported in mutated than not mutated cases, although this difference did not reach statistical significance. GBA mutations were significantly more frequent in patients with positive family history (15,9%) than sporadic cases (9%). About half mutated cases (34/71) originated from Campania, while the others came mostly from Lazio, Abruzzo and Sicily. These findings suggest that sequencing of the whole GBA gene should be considered in patients with PD, LBD and especially EOP if other monogenic forms have been excluded, even more in case of positive family history and if coming from high prevalence regions such as Campania

Changes in surgicaL behaviOrs dUring the CoviD-19 pandemic. The SICE CLOUD19 Study

BACKGROUND: The spread of the SARS-CoV2 virus, which causes COVID-19 disease, profoundly impacted the surgical community. Recommendations have been published to manage patients needing surgery during the COVID-19 pandemic. This survey, under the aegis of the Italian Society of Endoscopic Surgery, aims to analyze how Italian surgeons have changed their practice during the pandemic.METHODS: The authors designed an online survey that was circulated for completion to the Italian departments of general surgery registered in the Italian Ministry of Health database in December 2020. Questions were divided into three sections: hospital organization, screening policies, and safety profile of the surgical operation. The investigation periods were divided into the Italian pandemic phases I (March-May 2020), II (June-September 2020), and III (October-December 2020).RESULTS: Of 447 invited departments, 226 answered the survey. Most hospitals were treating both COVID-19-positive and -negative patients. The reduction in effective beds dedicated to surgical activity was significant, affecting 59% of the responding units. 12.4% of the respondents in phase I, 2.6% in phase II, and 7.7% in phase III reported that their surgical unit had been closed. 51.4%, 23.5%, and 47.8% of the respondents had at least one colleague reassigned to non-surgical COVID-19 activities during the three phases. There has been a reduction in elective (>200 procedures: 2.1%, 20.6% and 9.9% in the three phases, respectively) and emergency (<20 procedures: 43.3%, 27.1%, 36.5% in the three phases, respectively) surgical activity. The use of laparoscopy also had a setback in phase I (25.8% performed less than 20% of elective procedures through laparoscopy). 60.6% of the respondents used a smoke evacuation device during laparoscopy in phase I, 61.6% in phase II, and 64.2% in phase III. Almost all responders (82.8% vs. 93.2% vs. 92.7%) in each analyzed period did not modify or reduce the use of high-energy devices.CONCLUSION: This survey offers three faithful snapshots of how the surgical community has reacted to the COVID-19 pandemic during its three phases. The significant reduction in surgical activity indicates that better health policies and more evidence-based guidelines are needed to make up for lost time and surgery not performed during the pandemic