Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population.Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay.Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity.Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes

Exploring Local Explanations of Nonlinear Models Using Animated Linear Projections

The increased predictive power of nonlinear models comes at the cost of interpretability of its terms. This trade-off has led to the emergence of eXplainable AI (XAI). XAI attempts to shed light on how models use predictors to arrive at a prediction with local explanations, a point estimate of the linear feature importance in the vicinity of one instance. These can be considered linear projections and can be further explored to understand better the interactions between features used to make predictions across the predictive model surface. Here we describe interactive linear interpolation used for exploration at any instance and illustrate with examples with categorical (penguin species, chocolate types) and quantitative (soccer/football salaries, house prices) output. The methods are implemented in the R package cheem, available on CRAN.Comment: 24 pages, 9 figures, 0 table

"Is IEEE VIS *that* good?" On key factors in the initial assessment of manuscript and venue quality

Background: Academic performance is at the heart of hiring decisions and funding applications. It is based on a combination of qualitative and quantitative metrics. One of those is the venue in which scholarly publications are published. Depending on the perceived (qualitative) or measured (quantitative) prestige associated with a venue, a specific publication will have more or less weight. Objectives: We want to understand how visualization researchers consider the prestige of a venue when looking for papers that they could use in their own manuscripts, and how they determine the prestige of any given venue. Method: We ran an online survey open for 10 days that we sent out to visualization researchers. Results: We gathered 46 responses from a sample of convenience. We found that publication venue plays the biggest part in how visualization researchers assess research articles. Interestingly, rating systems and metrics are least important criteria for researchers when assessing the quality of a venue. Conclusion: We highlight the potential risks around focusing on venue when assessing research articles. We further underline the necessity to discuss with the community on strategies to switch the focus to robustness and reliability to foster better practices and less stressful publishing expectations. Reproducibility: Data, materials and preregistration available on osf.io/ch6p4

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19.

INTRODUCTION: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. METHODS: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. RESULTS: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. CONCLUSIONS: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes

Association of Country Income Level With the Characteristics and Outcomes of Critically Ill Patients Hospitalized With Acute Kidney Injury and COVID-19

Introduction: Acute kidney injury (AKI) has been identified as one of the most common and significant problems in hospitalized patients with COVID-19. However, studies examining the relationship between COVID-19 and AKI in low- and low-middle income countries (LLMIC) are lacking. Given that AKI is known to carry a higher mortality rate in these countries, it is important to understand differences in this population. Methods: This prospective, observational study examines the AKI incidence and characteristics of 32,210 patients with COVID-19 from 49 countries across all income levels who were admitted to an intensive care unit during their hospital stay. Results: Among patients with COVID-19 admitted to the intensive care unit, AKI incidence was highest in patients in LLMIC, followed by patients in upper-middle income countries (UMIC) and high-income countries (HIC) (53%, 38%, and 30%, respectively), whereas dialysis rates were lowest among patients with AKI from LLMIC and highest among those from HIC (27% vs. 45%). Patients with AKI in LLMIC had the largest proportion of community-acquired AKI (CA-AKI) and highest rate of in-hospital death (79% vs. 54% in HIC and 66% in UMIC). The association between AKI, being from LLMIC and in-hospital death persisted even after adjusting for disease severity. Conclusions: AKI is a particularly devastating complication of COVID-19 among patients from poorer nations where the gaps in accessibility and quality of healthcare delivery have a major impact on patient outcomes