Sticky policies approach within cloud computing

This paper discusses a secure document sharing approach, which addresses confidentiality, integrity and authenticity concerns related to cloud-based data sharing. This research is focused on a secure construct that would integrate with other cloud ready standards and products for data protection. Sticky policies recently considered as one of the preferred cloud data protection techniques are here combined with standardized OOXML data package. The defined model leverages the Identity Based Encryption (IBE) scheme to attach sticky policies to the data. This paper also shows several security features and functions that are suitable for secure data sharing in the cloud. Technologies used for proposed construction are not new, therefore only their unique combination with AES key derived from XACML sticky policy via IBE and OOXML wrapper constitutes novelty of this research

Cloud-based identity and identity meta-data: secure and control own data in globalization era.

This paper proposes a new identity, and its underlying meta-data, model. The approach enables secure spanning of identity meta-data across many boundaries such as health-care, financial and educational institutions, including all others that store and process sensitive personal data. It introduces the new concepts of Compound Personal Record (CPR) and Compound Identifiable Data (CID) ontology, which aim to move toward own your own data model. The CID model ensures: authenticity of identity meta-data; high availability via unified Cloud-hosted XML data structure; and privacy through encryption, obfuscation and anonymity applied to Ontology-based XML distributed content. Additionally CID via XML ontologies is enabled for identity federation. The paper also proposes that access over sensitive data is strictly governed through an access control model with granular policy enforcement on the service side. This includes the involvement of relevant access control model entities which are enabled to authorize an ad-hoc break-glass data access which should give high accountability for data access attempts

Genomic imbalance of HMMR/RHAMM regulates the sensitivity and response of malignant peripheral nerve sheath tumour cells to aurora kinase inhibition

Malignant peripheral nerve sheath tumours (MPNST) are rare, hereditary cancers associated with neurofibromatosis type I. MPNSTs lack effective treatment options as they often resist chemotherapies and have high rates of disease recurrence. Aurora kinase A (AURKA) is an emerging target in cancer and an aurora kinase inhibitor (AKI), termed MLN8237, shows promise against MPNST cell lines in vitro and in vivo. Here, we test MLN8237 against two primary human MPNST grown in vivo as xenotransplants and find that treatment results in tumour cells exiting the cell cycle and undergoing endoreduplication, which cumulates in stabilized disease. Targeted therapies can often fail in the clinic due to insufficient knowledge about factors that determine tumour susceptibilities, so we turned to three MPNST cell-lines to further study and modulate the cellular responses to AKI. We find that the sensitivity of cell-lines with amplification of AURKA depends upon the activity of the kinase, which correlates with the expression of the regulatory gene products TPX2 and HMMR/RHAMM. Silencing of HMMR/RHAMM, but not TPX2, augments AURKA activity and sensitizes MPNST cells to AKI. Furthermore, we find that AURKA activity is critical to the propagation and self-renewal of sphere-enriched MPNST cancer stem-like cells. AKI treatment significantly reduces the formation of spheroids, attenuates the self-renewal of spheroid forming cells, and promotes their differentiation. Moreover, silencing of HMMR/RHAMM is sufficient to endow MPNST cells with an ability to form and maintain sphere culture. Collectively, our data indicate that AURKA is a rationale therapeutic target for MPNST and tumour cell responses to AKI, which include differentiation, are modulated by the abundance of HMMR/RHAMM

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Mathematical model of dynamic work conditions in the measuring chamber of an air gauge

The goal of the proposed computational model was to evaluate the dynamical properties of air gauges in order to exploit them in such industrial applications as in-process control, form deviation measurement, dynamical measurement. The model is based on Reynolds equations complemented by the k-ε turbulence model. The boundary conditions were set in different areas (axis of the chamber, side surfaces, inlet pipeline and outlet cross-section) as Dirichlet's and Neumann's ones. The TDMA method was applied and the efficiency of the calculations was increased due to the "line-by-line" procedure. The proposed model proved to be accurate and useful for non-stationary two-dimensional flow through the air gauge measuring chamber

Ecosystem Service Trade-Offs in Peri-Urban Landscapes: Drivers, Governance Obstacles and Improvements

Trade-offs in ecosystem services (ESs) manifest when the enhancement of one service leads to the diminishment of another. These trade-offs pose a notable challenge, impacting the sustainability of particular socioecological system peri-urban landscapes (PULs). This issue arises from the dynamic processes associated with peri-urbanization, which threaten natural ecosystems and their services in peri-urban areas. Additionally, the escalating demand for ecosystem services in PULs contributes to these trade-offs. Policymaking and planning concerning ES trade-offs in PULs should prioritize promoting a balance between conflicting services and fostering synergies among them. However, it is noteworthy that ES trade-offs in PULs are not given high priority in policy and planning agendas. Knowledge regarding policy development and planning for ES trade-offs in PULs often remains concealed within specific country and regional case studies. Consequently, this research seeks to characterize the ES trade-offs in selected PUL case studies, with the objective of identifying potential commonalities among them. Furthermore, this study aims to identify (i) the factors driving ES trade-offs, (ii) challenges related to how policymaking and planning address ES trade-offs in PULs, and (iii) recommendations for enhancing governance practices to better manage peri-urban ES trade-offs. We designed a semi-quantitative survey and collected information about 24 case studies located across the world. The answers from this survey were analyzed using principal component analysis. The results showed that the most common trade-offs occurred between “cultural and provisioning” and “regulating and provisioning” ESs. It was found that urban development is the primary driver behind the emergence of the examined trade-offs. To address this issue at the governance level, this study recommends establishing mechanisms to facilitate collaboration among stakeholders. This should be accompanied by robust dissemination efforts and the promotion of awareness among actors regarding the fundamental concepts of ESs and PULs