23 research outputs found
Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTICâHF: baseline characteristics and comparison with contemporary clinical trials
Aims:
The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTICâHF) trial. Here we describe the baseline characteristics of participants in GALACTICâHF and how these compare with other contemporary trials.
Methods and Results:
Adults with established HFrEF, New York Heart Association functional class (NYHA)ââ„âII, EF â€35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokineticâguided dosing: 25, 37.5 or 50âmg bid). 8256 patients [male (79%), nonâwhite (22%), mean age 65âyears] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NTâproBNP 1971âpg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTICâHF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressureâ<â100âmmHg (n = 1127), estimated glomerular filtration rate <â30âmL/min/1.73 m2 (n = 528), and treated with sacubitrilâvalsartan at baseline (n = 1594).
Conclusions:
GALACTICâHF enrolled a wellâtreated, highârisk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation
Einfluss neutrophiler Granulozyten auf die Angiogenese bei Patienten mit HÀmorrhagischer HereditÀrer Teleangiektasie (HHT)
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Academic literature review on violence prevention in secure settings: findings from a scoping review commissioned by HMYOI Werrington, completed by Nottingham Trent University
VerÀnderungen des Immunsystems der Patienten mit HÀmorrhagischer HereditÀrer Teleangiektasie (HHT)
Are there differences in the fouling of the native and invasive Unionidae by Dreissena polymorpha
The Importance of the Mining Subsidence Reservoirs Located Along the Trans-Regional Highway in the Conservation of the Biodiversity of Freshwater Molluscs in Industrial Areas (Upper Silesia, Poland)
The objectives of the survey were to analyse
the structure of the mollusc communities in the mining
subsidence reservoirs that were created as a result of
land subsidence over exploited hard coal seams and to
determine the most predictive environmental factors that
influence the distribution of mollusc species. The reservoirs
are located in urbanised and industrialised areas
along the Trans-Regional Highway, which has a high
volume of vehicular traffic. They all have the same
sources of supply but differ in the physical and chemical
parameters of the water. In total, 15 mollusc species
were recorded including four bivalve species. Among
them Anodonta cygnea is classified as Endangered according
to the Polish Red Data Book of Animals and
also as Near Threatened according to the European Red
List of Non-marine Molluscs. Eleven of the 15 mollusc
species are included on the European Red List of Nonmarine
Molluscs as Least Concern. Conductivity, pH
and the concentration of calcium were the parameters
most associated with the distribution of mollusc species.
Canonical correspondence analysis showed that
Potamopyrgus antipodarum, Radix balthica, Physella
acuta, Gyraulus crista and Pisidium casertanum were
associated with higher conductivity and lower pH
values. A. cygnea, Anodonta anatina and Ferrissia
fragilis were negatively influenced by these parameters
of the water. The results of this survey showed that the
mining subsidence reservoirs located in urbanised and
industrialised areas provide refuges for rare and legally
protected species and that they play an essential role in
the dispersal of alien species as well
Response of the mollusc communities to environmental factors along an anthropogenic salinity gradient
Results, Old and New, in Computed Tomography
Introduction Computed tomography (CT) entails the reconstruction of a function f from line integrals of f . This mathematical problem is encountered in a growing number of diverse settings in medicine, science, and technology, ranging from the famous application in diagnostic radiology to recent research in quantum optics. As a consequence, many aspects of CT have been extensively studied and are now well understood, thus providing an interesting model case for the study of other inverse problems. Other aspects, notably three-dimensional reconstructions, still provide numerous open problems. The present article grew out of a series of tutorial talks given by the author at the IMA. In the spirit of such talks, it attempts to provide a brief introduction to the subject, highlight some aspects of general interest, sketch some recent developments, and point out references for further study. In practice only integrals over finitely many lines can b