Cannabis Analysis II: Detection of Cannabinoid Acids that Inhibit COVID-19 Infection in Consumer Products

The cannabis plant (Cannabis Sativa L., aka hemp) produces a variety of compounds covering numerous chemical classes such as cannabinoids, terpenes, and terpenoids. The cannabinoid subclass which produces psychoactive and other pharmacological effects includes chemically neutral and acidic compounds. Cannabinoid acids were recently proven to be effective at binding to the spike protein of the COVID-19 virus and thus inhibited cell entry, replication, and infection. Analysis of these compounds can be performed by numerous techniques including Gas Chromatography-Electron Impact-Mass Spectrometry (GC-EI-MS). We developed a targeted methodology to analyze four of the known acids commonly found in consumer products by GC-EI-MS. Since the cannabinoid acids are prone to decarboxylate at elevated temperatures and revert to their neutral counterparts (ex. CBDA to CBD, THCA to THC), they are found formulated mainly into non-smokable consumer products. The elevated temperatures used in GC-EI-MS analysis necessitated the addition of a protective group to active –OH groups via derivatization. This methodology proved to be effective at overcoming decarboxylation and allowed the acids to survive the analysis

The Advancing State of AF-M315E Technology

The culmination of twenty years of applied research in hydroxyl ammonium nitrate (HAN)-based monopropellants, the NASA Space Technology mission Directorate's (STMD) Green Propellant Infusion Mission (GPIM) will achieve the first on-orbit demonstration of an operational AF-M315E green propellant propulsion system by the end of 2015. Following an contextual overview of the completed flight design of the GPIM propellant storage and feed system, results of first operation of a flight-representative heavyweight 20-N engineering model thruster (to be conducted in mid-2014) are presented with performance comparisons to prior lab model (heavyweight) test articles

Establishing a Robotic, LEO-to-GEO Satellite Servicing Infrastructure as an Economic Foundation for Exploration

The strategy for accomplishing civilian exploration goals and objectives is in the process of a fundamental shift towards a potential new approach called Flexible Path. This paper suggests that a government-industry or public-private partnership in the commercial development of low Earth orbit to geostationary orbit (LEO-to-GEO (LTG)) space, following or in parallel with the commercialization of Earth-to-LEO and International Space Station (ISS) operations, could serve as a necessary, logical step that can be incorporated into the flexible path approach. A LTG satellite-servicing infrastructure and architecture concept is discussed within this new strategic context. The concept consists of a space harbor that serves as a transport facility for a fleet of specialized, fully- or semi-autonomous robotic servicing spacecraft. The baseline, conceptual system architecture is composed of a space harbor equipped with specialized servicer spacecraft; a satellite command, communication, and control system; a parts station; a fuel station or depot; and a fuel/parts replenishment transport. The commercial servicer fleet would consist of several types of spacecraft, each designed with specialized robotic manipulation subsystems to provide services such as refueling, upgrade, repair, inspection, relocation, and removal. The space harbor is conceptualized as an ISS-type, octagonal truss structure equipped with radiation tolerant subsystems. This space harbor would be primarily capable of serving as an operational platform for various commercially owned and operated servicer spacecraft positioned and docked symmetrically on four of the eight sides. Several aspects of this concept are discussed, such as: system-level feasibility in terms of ISS-truss-type infrastructure and subsystems emplacement and maintenance between LEO and GEO; infrastructure components assembly in LEO, derived from ISS assembly experience, and transfer to various higher orbital locations; the evolving Earth-to-orbit (ETO) capability to deliver humans and cargo to LEO for assembly purposes; system architectural definition, optimal orbital parameters, mass estimations, delta velocity ( V) estimations, power and propulsion options, and assessments of various critical technologies. Large-scale, robotic, LTG satellite servicing is considered as an essential economic pre-condition and next parallel or sequential step on the road toward exploration beyond LEO. Such a step might produce the necessary pre-requisite economic value that can be used by future decision makers to justify further investment in exploration beyond LEO