A proposal for curriculum content in transfusion medicine and blood banking education in pathology residency programs

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/71606/1/j.1537-2995.2007.01417.x.pd

ZOOMICS: comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days

The use of omics technologies in human transfusion medicine has improved our understanding of the red blood cell (RBC) storage lesion(s). Despite significant progress towards understanding the storage lesion(s) of human RBCs, a comparison of basal and post-storage RBC metabolism across multiple species using omics technologies has not yet been reported, and is the focus of this study

Nuclear Power Feasibility 2007

Nuclear power is a proven technology and has the potential to generate virtually limitless energy with no significant greenhouse gas emissions. Nuclear power can become one of the main options to contribute to substantial cuts in global greenhouse gas emissions. Modern development of nuclear power technology and the established framework of international agreements and conventions are responding to the major political, economic and environmental issues -high capital costs, the risks posed by nuclear waste and accidents, and the proliferation of nuclear weaponry- that until recently hindered the expansion of nuclear power. In response to such prospects, the WFEO Energy Standing Committee set up a Task Group to develop this Report on NUCLEAR POWER FEASIBILITY - 2008. This Report gathers information on the state-of-the-art of nuclear energy technology and its current technical and economic feasibility based on engineering criteria and technological maturity. Members of the Task Group were appointed by WFEO Member Organizations. This Report is being presented as a publication in the Energy Standing Committee Series on Feasibility of Current Energy Options. The Series is intended to give the viewpoint of the engineer on questions related to technical and economic feasibility of energy issues of significance to society. It aims at providing the engineer and decision making officers with updated information regarding the state-of-the-art of different technologies that are being used or are under consideration for the supply of energy

NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

Because blood transfusion is one of the most common therapeutic interventions in hospitalized patients, much recent research has focused on improving the storage quality in vitro of donor red blood cells (RBCs) that are then used for transfusion. However, there is a significant need for enhancing our understanding of the efficacy of the transfused RBCs in vivo. To this end, the NIH sponsored a one-and-a-half-day workshop that brought together experts in multiple disciplines relevant to tissue oxygenation (eg, transfusion medicine, critical care medicine, cardiology, neurology, neonatology and pediatrics, bioengineering, biochemistry, and imaging). These individuals presented their latest findings, discussed key challenges, and aimed to identify opportunities for facilitating development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally-invasive to non-invasive fashion, before and after RBC transfusion

NIH Workshop 2018: Towards Minimally-invasive or Non-invasive Approaches to Assess Tissue Oxygenation Pre- and Post-Transfusion

Because blood transfusion is one of the most common therapeutic interventions in hospitalized patients, much recent research has focused on improving the storage quality in vitro of donor red blood cells (RBCs) that are then used for transfusion. However, there is a significant need for enhancing our understanding of the efficacy of the transfused RBCs in vivo. To this end, the NIH sponsored a one-and-a-half-day workshop that brought together experts in multiple disciplines relevant to tissue oxygenation (e.g., transfusion medicine, critical care medicine, cardiology, neurology, neonatology and pediatrics, bioengineering, biochemistry, and imaging). These individuals presented their latest findings, discussed key challenges, and aimed to construct recommendations for facilitating development of new technologies and/or biomarker panels to assess tissue oxygenation in a minimally-invasive to non-invasive fashion, before and after RBC transfusion. The workshop was structured into four sessions: (1) Global Perspective; (2) Organ Systems; (3) Neonatology; and (4) Emerging Technologies. The first day provided an overview of current approaches in the clinical setting, both from a global perspective, including the use of metabolomics for studying RBCs and tissue perfusion, and from a more focused perspective, including tissue oxygenation assessments in neonates and in specific adult organ systems. The second day focused on emerging technologies, which could be applied pre- and post-RBC transfusion, to assess tissue oxygenation in minimally-invasive or non-invasive ways. Each day concluded with an open-microphone discussion among the speakers and workshop participants. The workshop presentations and ensuing interdisciplinary discussions highlighted the potential of technologies to combine global “omics” signatures with additional measures (e.g., thenar eminence measurements or various imaging methods) to predict which patients could potentially benefit from a RBC transfusion and whether the ensuing RBC transfusion was effective. The discussions highlighted the need for collaborations across the various disciplines represented at the meeting to leverage existing technologies and to develop novel approaches for assessing RBC transfusion efficacy in various clinical settings. Although the Workshop took place in April, 2018, the concepts described and the ensuing discussions were, perhaps, even more relevant in April, 2020, at the time of writing this manuscript, during the explosive growth of the COVID-19 pandemic in the United States. Thus, issues relating to maintaining and improving tissue oxygenation and perfusion are especially pertinent because of the extensive pulmonary damage resulting from SARS-CoV-2 infection [1], compromises in perfusion caused by thrombotic-embolic phenomena [2], and damage to circulating RBCs, potentially compromising their oxygen-carrying capacity [3]. The severe end organ effects of SARS-CoV-2 infection mandate even more urgency for improving our understanding of tissue perfusion and oxygenation, improve methods for measuring and monitoring them, and develop novel ways of enhancing them

Sociometric and disruptive behavior as a function of four types of token reinforcement programs

Children in a first-grade classroom were divided into four groups. Baseline measures of disruptive classroom behavior were taken on a well-behaved and disruptive child in each group. Following baseline, four types of token economies were simultaneously introduced and rotated every 10 days within a Latin Square design. The token economies were: (1) individual reinforcement determined by individual performance; (2) group reinforcement determined by the behavior of the most disruptive child; (3) group reinforcement determined by the behavior of the least disruptive child; (4) group reinforcement determined by the behavior of a randomly chosen child. The token economies were compared on their effectiveness in changing target behavior, preference by the targets, ease of use, and cost. Additionally, sociometric responses were taken on questions of responsibility, friendship, and funniness. Results showed a significant decrease of inappropriate behavior for the disruptive children and no difference between the effectiveness of the four types of token economies in producing behavior change. However, there were other differences that indicated that the system in which group reinforcement was determined by a randomly selected child would be desirable for most teachers. Results also showed changes in the sociometric status of the disruptive children. As predicted, disruptive children were rated as more responsible when they were in the group reinforcement determined by the most disruptive child in the group token economy. Using behavior modification techniques indirectly to change sociometric status is suggested as offering a new potential technique for behavior change agents