Multi Scale Modelling of Friction Induced Vibrations at the Example of a Disc Brake System

Friction induced vibrations such as brake squealing, or juddering are still challenging topics in product engineering processes. So far, this topic was particularly relevant for the automobile industry because they were the main market for disc brake systems. However, since mobility habits change, disc brake system are more often to be found on bikes or e-scooters. In all of these systems, vibrations are excited in contacts on the micro scale but affect the user comfort and safety on the macro scale. Therefore, the aim of this cross-scale method is to analyze a system on a micro scale and to transfer the excitation mechanisms on a macro scale system. To address both scales, the current work presents a finite element model on the micro scale for the determination of the coefficient of friction, which is transferred to the macro scale and used in a multi-body simulation. Finally, a finite element modal analysis is conducted, which allowed us to evaluate the brake system behavior on base of an excitation

Multi Scale Modelling of Friction Induced Vibrations at the Example of a Disc Brake System

Friction induced vibrations such as brake squealing, or juddering are still challenging topics in product engineering processes. So far, this topic was particularly relevant for the automobile industry because they were the main market for disc brake systems. However, since mobility habits change, disc brake system are more often to be found on bikes or e-scooters. In all of these systems, vibrations are excited in contacts on the micro scale but affect the user comfort and safety on the macro scale. Therefore, the aim of this cross-scale method is to analyze a system on a micro scale and to transfer the excitation mechanisms on a macro scale system. To address both scales, the current work presents a finite element model on the micro scale for the determination of the coefficient of friction, which is transferred to the macro scale and used in a multi-body simulation. Finally, a finite element modal analysis is conducted, which allowed us to evaluate the brake system behavior on base of an excitation

Rapid clinical-scale propagation of mesenchymal stem cells using cultures initiated with immunoselected bone marrow CD105(+) cells

Current clinical protocols used for isolation and purification of mesenchymal stem cells (MSC) are based on long-term cultures starting with bone marrow (BM) mononuclear cells. Using a commercially available immunoselection kit for enrichment of MSC, we investigated whether culture of enriched BM-CD105(+) cells could provide an adequate number of pure MSC in a short time for clinical use in the context of graft versus host disease and graft failure/rejection. We isolated a mean of 5.4 x 10(5) +/- 0.9 x 10(5) CD105(+) cells from 10 small volume (10-25 ml) BM samples achieving an enrichment > 100-fold in MSC. Seeding 2 x 10(3) immunoselected cells/cm(2) we were able to produce 2.5 x 10(8) +/- 0.7 x 10(8) MSC from cultures with autologous serum enriched medium within 3 weeks. Neither haematopoietic nor endothelial cells were detectable even in the primary culture cell product. Expanded cells fulfilled both phenotypic and functional current criteria for MSC; they were CD29(+), CD90(+), CD73(+), CD105(+), CD45(-); they suppressed allogeneic T-cell reaction in mixed lymphocyte cultures and retained in vitro differentiation potential. Moreover, comparative genomic hybridization analysis revealed chromosomal stability of the cultured MSC. Our data indicate that adequate numbers of pure MSC suitable for clinical applications can be generated within a short time using enriched BM-CD105(+) cells