412 research outputs found
Minimal Seesaw as an Ultraviolet Insensitive Cure for the Problems of Anomaly Mediation
We show that an intermediate scale supersymmetric left-right seesaw scenario
with automatic R-parity conservation can cure the problem of tachyonic slepton
masses that arises when supersymmetry is broken by anomaly mediation, while
preserving ultraviolet insensitivity. The reason for this is the existence of
light B - L = 2 higgses with yukawa couplings to the charged leptons. We find
these theories to have distinct predictions compared to the usual mSUGRA and
gauge mediated models as well as the minimal AMSB models. Such predictions
include a condensed gaugino mass spectrum and possibly a correspondingly
condensed sfermion spectrum.Comment: 19 pages, 1 figur
Running with Triplets: How Slepton Masses Change With Doubly-Charged Higgses
We examine the slepton masses of SUSYLR models and how they change due the
presence of light-doubly charged higgs bosons. We discover that the measurement
of the slepton masses could bound and even predict the value of the third
generation Yukawa coupling of leptons to the SU(2)_R Triplets. We also consider
the unification prospects for this model with the addition of left-handed, B -
L = 0 triplets--a model we call the Triplet Extended Supersymmetric Standard
Model (TESSM). Finally, we discuss the changes in the slepton masses due to the
presence of the SU(2)_L triplets.Comment: 20 pages, 6 figures, 4 table
When Anomaly Mediation is UV Sensitive
Despite its successes---such as solving the supersymmetric flavor
problem---anomaly mediated supersymmetry breaking is untenable because of its
prediction of tachyonic sleptons. An appealing solution to this problem was
proposed by Pomarol and Rattazzi where a threshold controlled by a light field
deflects the anomaly mediated supersymmetry breaking trajectory, thus evading
tachyonic sleptons. In this paper we examine an alternate class of deflection
models where the non-supersymmetric threshold is accompanied by a heavy,
instead of light, singlet. The low energy form of this model is the so-called
extended anomaly mediation proposed by Nelson and Weiner, but with potential
for a much higher deflection threshold. The existence of this high deflection
threshold implies that the space of anomaly mediated supersymmetry breaking
deflecting models is larger than previously thought.Comment: 14 pages, 1 figure (version to appear in JHEP
Seesaw Extended MSSM and Anomaly Mediation without Tachyonic Sleptons
Superconformal anomalies provide an elegant and economical way to understand
the soft breaking parameters in SUSY models; however, implementing them leads
to the several undesirable features including: tachyonic sleptons and
electroweak symmetry breaking problems in both the MSSM and the NMSSM. Since
these two theories also have the additonal problem of massless neutrinos, we
have reconsidered the AMSB problems in a class of models that extends the NMSSM
to explain small neutrino masses via the seesaw mechanism. In a recent paper,
we showed that for a class of minimal left-right extensions, a built-in
mechanism exists which naturally solves the tachyonic slepton problem and
provides new alternatives to the MSSM that also have automatic R-parity
conservation. In this paper, we discuss how electroweak symmetry breaking
arises in this model through an NMSSM-like low energy theory with a singlet
VEV, induced by the structure of the left-right extension and of the right
magnitude. We then study the phenomenological issues and find: the LSP is an
Higgsino-wino mix, new phenomenology for chargino decays to the LSP, degenerate
same generation sleptons and a potential for a mild squark-slepton degeneracy.
We also discuss possible collider signatures and the feasibility of dark matter
in this model.Comment: 40 pages, 10 figures, 5 tables; v3: Added addendum and three new
references; v4: Added reference that was inadvertently omitte
Fiber Acoustic Waveguide : A Sensor Candidate
Sensor development plays a key role in the field of nondestructive evaluation and process control. The annual fiber optic sensor market alone is a multimillion dollar business (1). Acoustic waves are about five orders of magnitude slower than optical waves and can also be guided in cladded glass fibers, similar to optical fibers, with low loss and low dispersion (2–7). Fiber acoustic waveguides are believed to be a very attractive and basic component for further sensor development (8). In this paper a brief theoretical description of a weakly guiding acoustic fiber (7) is given. The material selection criteria for the core and the cladding of the fiber guide, the properties of single-mode operation, and some sensing mechanisms for temperature and pressure variations are discussed. The acoustic waveguide with a liquid core is also considered
Fibrous Monolithic Ceramics: III, Mechanical Properties and Oxidation Behavior of the Silicon Carbide/Boron Nitride System
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66176/1/j.1151-2916.1994.tb05399.x.pd
An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders
Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of major mental disorders (MMDs),
which should be considered the result of an evolutionary downside trade off. Temperamental/trait variability, by facilitating choices
for individual and group responses, confers robustness flexibility and resilience crucial to success of our species. Extreme temperamental variants, originating evolutionarily from the asocial aspect of human nature, also constitute the premorbid personality
of the disorders. The latter create vulnerable individuals out of whom some will develop MMDs but at much higher rate to that of the general population. Significantly, similar temperamental “lopsidedness� enables many of these vulnerable individuals, if intelligent, tenacious, and curious, to be creative and contribute to our survival while some may also develop MMDs. All have a common neural-developmental origin and share characteristics in their clinical expression and pharmacological responses also expressed as mixed syndromes or alternating ones over time. Over-pruning of synaptic neurons may be considered the trigger of such occurrences
or conversely, the failure to prevent them in spite of it. The symptoms of the major mental disorders are made up of antithetical substitutes as an expression of a disturbed over-all synchronizing property of brain function for all higher faculties previously unconsidered in their modeling. The concomitant presence of psychosis is a generic common occurrence
Action spectroscopy of gas-phase carboxylate anions by multiple photon IR electron detachment/attachment
We report on a form of gas-phase anion action spectroscopy based on infrared
multiple photon electron detachment and subsequent capture of the free
electrons by a neutral electron scavenger in a Fourier Transform Ion Cyclotron
Resonance (FTICR) mass spectrometer. This method allows one to obtain
background-free spectra of strongly bound anions, for which no dissociation
channels are observed. The first gas-phase spectra of acetate and propionate
are presented using SF6 as electron scavenger and a free electron laser as
source of intense and tunable infrared radiation. To validate the method, we
compare infrared spectra obtained through multiple photon electron
detachment/attachment and multiple photon dissociation for the benzoate anion.
In addition, different electron acceptors are used, comparing both associative
and dissociative electron capture. The relative energies of dissociation (by
CO2 loss) and electron detachment are investigated for all three anions by DFT
and CCSD(T) methods. DFT calculations are also employed to predict vibrational
frequencies, which provide a good fit to the infrared spectra observed. The
frequencies of the symmetric and antisymmetric carboxylate stretching modes for
the aliphatic carboxylates are compared to those previously observed in
condensed-phase IR spectra and to those reported for gas-phase benzoate,
showing a strong influence of the solution environment and a slight substituent
effect on the antisymmetric stretch.Comment: Revised version, Submitted to J Phys Chem
Longitudinal Outcomes of Gender Identity in Children (LOGIC): study protocol for a retrospective analysis of the characteristics and outcomes of children referred to specialist gender services in the UK and the Netherlands
INTRODUCTION: Specialist gender services for children and young people (CYP) worldwide have experienced a significant increase in referrals in recent years. As rates of referrals increase, it is important to understand the characteristics and profile of CYP attending these services in order to inform treatment pathways and to ensure optimal outcomes. METHODS AND ANALYSIS: A retrospective observational study of clinical health records from specialist gender services for CYP in the UK and the Netherlands. The retrospective analysis will examine routinely collected clinical and outcome measures data including demographic, clinical, gender identity-related and healthcare resource use information. Data will be reported for each service and also compared between services. This study forms part of a wider programme of research investigating outcomes of gender identity in children (the Longitudinal Outcomes of Gender Identity in Children study). ETHICS AND DISSEMINATION: The proposed study has been approved by the Health Research Authority and London-Hampstead Research Ethics Committee as application 19/LO/0181. The study findings will be published in peer-reviewed journals and presented at both conferences and stakeholder events
Identification of PKD1L1 Gene Variants in Children with the Biliary Atresia Splenic Malformation Syndrome
Biliary atresia (BA) is the most common cause of end‐stage liver disease in children and the primary indication for pediatric liver transplantation, yet underlying etiologies remain unknown. Approximately 10% of infants affected by BA exhibit various laterality defects (heterotaxy) including splenic abnormalities and complex cardiac malformations — a distinctive subgroup commonly referred to as the biliary atresia splenic malformation (BASM) syndrome. We hypothesized that genetic factors linking laterality features with the etiopathogenesis of BA in BASM patients could be identified through whole exome sequencing (WES) of an affected cohort. DNA specimens from 67 BASM subjects, including 58 patient‐parent trios, from the NIDDK‐supported Childhood Liver Disease Research Network (ChiLDReN) underwent WES. Candidate gene variants derived from a pre‐specified set of 2,016 genes associated with ciliary dysgenesis and/or dysfunction or cholestasis were prioritized according to pathogenicity, population frequency, and mode of inheritance. Five BASM subjects harbored rare and potentially deleterious bi‐allelic variants in polycystin 1‐like 1, PKD1L1, a gene associated with ciliary calcium signaling and embryonic laterality determination in fish, mice and humans. Heterozygous PKD1L1 variants were found in 3 additional subjects. Immunohistochemical analysis of liver from the one BASM subject available revealed decreased PKD1L1 expression in bile duct epithelium when compared to normal livers and livers affected by other non‐cholestatic diseases. Conclusion WES identified bi‐allelic and heterozygous PKD1L1 variants of interest in 8 BASM subjects from the ChiLDReN dataset. The dual roles for PKD1L1 in laterality determination and ciliary function suggest that PKD1L1 is a new, biologically plausible, cholangiocyte‐expressed candidate gene for the BASM syndrome
- …