297 research outputs found
A Kerr-microresonator optical clockwork
Kerr microresonators generate interesting and useful fundamental states of
electromagnetic radiation through nonlinear interactions of continuous-wave
(CW) laser light. Using photonic-integration techniques, functional devices
with low noise, small size, low-power consumption, scalable fabrication, and
heterogeneous combinations of photonics and electronics can be realized. Kerr
solitons, which stably circulate in a Kerr microresonator, have emerged as a
source of coherent, ultrafast pulse trains and ultra-broadband
optical-frequency combs. Using the f-2f technique, Kerr combs support
carrier-envelope-offset phase stabilization for optical synthesis and
metrology. In this paper, we introduce a Kerr-microresonator optical clockwork
based on optical-frequency division (OFD), which is a powerful technique to
transfer the fractional-frequency stability of an optical clock to a lower
frequency electronic clock signal. The clockwork presented here is based on a
silicon-nitride (SiN) microresonator that supports an optical-frequency
comb composed of soliton pulses at 1 THz repetition rate. By electro-optic
phase modulation of the entire SiN comb, we arbitrarily generate
additional CW modes between the SiN comb modes; operationally, this
reduces the pulse train repetition frequency and can be used to implement OFD
to the microwave domain. Our experiments characterize the residual frequency
noise of this Kerr-microresonator clockwork to one part in , which
opens the possibility of using Kerr combs with high performance optical clocks.
In addition, the photonic integration and 1 THz resolution of the SiN
frequency comb makes it appealing for broadband, low-resolution liquid-phase
absorption spectroscopy, which we demonstrate with near infrared measurements
of water, lipids, and organic solvents
In-beam internal conversion electron spectroscopy with the SPICE detector
The SPectrometer for Internal Conversion Electrons (SPICE) has been
commissioned for use in conjunction with the TIGRESS -ray spectrometer
at TRIUMF's ISAC-II facility. SPICE features a permanent rare-earth magnetic
lens to collect and direct internal conversion electrons emitted from nuclear
reactions to a thick, highly segmented, lithium-drifted silicon detector. This
arrangement, combined with TIGRESS, enables in-beam -ray and internal
conversion electron spectroscopy to be performed with stable and radioactive
ion beams. Technical aspects of the device, capabilities, and initial
performance are presented
Radio-Excess IRAS Galaxies: PMN/FSC Sample Selection
A sample of 178 extragalactic objects is defined by correlating the 60 micron
IRAS FSC with the 5 GHz PMN catalog. Of these, 98 objects lie above the
radio/far-infrared relation for radio-quiet objects. These radio-excess
galaxies and quasars have a uniform distribution of radio excesses and appear
to be a new population of active galaxies not present in previous
radio/far-infrared samples. The radio-excess objects extend over the full range
of far-infrared luminosities seen in extragalactic objects. Objects with small
radio excesses are more likely to have far-infrared colors similar to
starbursts, while objects with large radio excesses have far-infrared colors
typical of pure AGN. Some of the most far-infrared luminous radio-excess
objects have the highest far-infrared optical depths. These are good candidates
to search for hidden broad line regions in polarized light or via near-infrared
spectroscopy. Some low far-infrared luminosity radio-excess objects appear to
derive a dominant fraction of their far-infrared emission from star formation,
despite the dominance of the AGN at radio wavelengths. Many of the radio-excess
objects have sizes likely to be smaller than the optical host, but show
optically thin radio emission. We draw parallels between these objects and high
radio luminosity Compact Steep-Spectrum (CSS) and GigaHertz Peaked-Spectrum
(GPS) objects. Radio sources with these characteristics may be young AGN in
which the radio activity has begun only recently. Alternatively, high central
densities in the host galaxies may be confining the radio sources to compact
sizes. We discuss future observations required to distinguish between these
possibilities and determine the nature of radio-excess objects.Comment: Submitted to AJ. 44 pages, 11 figures. A version of the paper with
higher quality figures is available from
http://www.mso.anu.edu.au/~cdrake/PMNFSC/paperI
Radiation Reveal: Moving from research engagement to involvement.
Here, we report on the process of a highly impactful and successful creative, collaborative, and multi-partner public engagement project, Radiation Reveal. It brought together ten young adults aged 17-25-year-olds with experience of radiotherapy with researchers at Cancer Research UK RadNet City of London across three 2-hour online workshops. Our aims were to 1) initiate discussions between young adults and radiation researchers, and 2) identify what people wish they had known about radiotherapy before or during treatment. These aims were surpassed; other benefits included peer support, participants' continued involvement in subsequent engagement projects, lasting friendships, creation of support groups for others, and creation and national dissemination of top ten tips for medical professionals and social media resources. A key learning was that this project required a dedicated and (com)passionate person with connections to national cancer charities. When designing the project, constant feedback is also needed from charities and young adults with and without radiotherapy experience. Finally, visually capturing discussions and keeping the door open beyond workshops further enhanced impact. Here, we hope to inform and inspire people to help project the patient voice in all we do
An Integrated-Photonics Optical-Frequency Synthesizer
Integrated-photonics microchips now enable a range of advanced
functionalities for high-coherence applications such as data transmission,
highly optimized physical sensors, and harnessing quantum states, but with
cost, efficiency, and portability much beyond tabletop experiments. Through
high-volume semiconductor processing built around advanced materials there
exists an opportunity for integrated devices to impact applications cutting
across disciplines of basic science and technology. Here we show how to
synthesize the absolute frequency of a lightwave signal, using integrated
photonics to implement lasers, system interconnects, and nonlinear frequency
comb generation. The laser frequency output of our synthesizer is programmed by
a microwave clock across 4 THz near 1550 nm with 1 Hz resolution and
traceability to the SI second. This is accomplished with a heterogeneously
integrated III/V-Si tunable laser, which is guided by dual
dissipative-Kerr-soliton frequency combs fabricated on silicon chips. Through
out-of-loop measurements of the phase-coherent, microwave-to-optical link, we
verify that the fractional-frequency instability of the integrated photonics
synthesizer matches the reference-clock instability for a 1
second acquisition, and constrain any synthesis error to while
stepping the synthesizer across the telecommunication C band. Any application
of an optical frequency source would be enabled by the precision optical
synthesis presented here. Building on the ubiquitous capability in the
microwave domain, our results demonstrate a first path to synthesis with
integrated photonics, leveraging low-cost, low-power, and compact features that
will be critical for its widespread use.Comment: 10 pages, 6 figure
Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study.
BACKGROUND: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on June 16, 2020, and to identify discrepancies in care. METHODS: We did an audit of clinical implementation of corticosteroids in a prospective, observational, cohort study in 237 UK acute care hospitals between March 16, 2020, and April 14, 2021, restricted to patients aged 18 years or older with proven or high likelihood of COVID-19, who received supplementary oxygen. The primary outcome was administration of dexamethasone, prednisolone, hydrocortisone, or methylprednisolone. This study is registered with ISRCTN, ISRCTN66726260. FINDINGS: Between June 17, 2020, and April 14, 2021, 47 795 (75·2%) of 63 525 of patients on supplementary oxygen received corticosteroids, higher among patients requiring critical care than in those who received ward care (11 185 [86·6%] of 12 909 vs 36 415 [72·4%] of 50 278). Patients 50 years or older were significantly less likely to receive corticosteroids than those younger than 50 years (adjusted odds ratio 0·79 [95% CI 0·70-0·89], p=0·0001, for 70-79 years; 0·52 [0·46-0·58], p80 years), independent of patient demographics and illness severity. 84 (54·2%) of 155 pregnant women received corticosteroids. Rates of corticosteroid administration increased from 27·5% in the week before June 16, 2020, to 75-80% in January, 2021. INTERPRETATION: Implementation of corticosteroids into clinical practice in the UK for patients with COVID-19 has been successful, but not universal. Patients older than 70 years, independent of illness severity, chronic neurological disease, and dementia, were less likely to receive corticosteroids than those who were younger, as were pregnant women. This could reflect appropriate clinical decision making, but the possibility of inequitable access to life-saving care should be considered. FUNDING: UK National Institute for Health Research and UK Medical Research Council
Low NO and variable CH fluxes from tropical forest soils of the Congo Basin
Globally, tropical forests are assumed to be an important source of atmospheric nitrous oxide (NO) and sink for methane (CH). Yet, although the Congo Basin comprises the second largest tropical forest and is considered the most pristine large basin left on Earth, in situ NO and CH flux measurements are scarce. Here, we provide multi-year data derived from on-ground soil flux (n = 1558) and riverine dissolved gas concentration (n = 332) measurements spanning montane, swamp, and lowland forests. Each forest type core monitoring site was sampled at least for one hydrological year between 2016 - 2020 at a frequency of 7-14 days. We estimate a terrestrial CH uptake (in kg CH-C ha yr) for montane (−4.28) and lowland forests (−3.52) and a massive CH release from swamp forests (non-inundated 2.68; inundated 341). All investigated forest types were a NO source (except for inundated swamp forest) with 0.93, 1.56, 3.5, and −0.19 kg NO-N ha yr for montane, lowland, non-inundated swamp, and inundated swamp forests, respectively
Long Covid in adults discharged from UK hospitals after Covid-19: A prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol.
Background: This study sought to establish the long-term effects of Covid-19 following hospitalisation. Methods: 327 hospitalised participants, with SARS-CoV-2 infection were recruited into a prospective multicentre cohort study at least 3 months post-discharge. The primary outcome was self-reported recovery at least ninety days after initial Covid-19 symptom onset. Secondary outcomes included new symptoms, disability (Washington group short scale), breathlessness (MRC Dyspnoea scale) and quality of life (EQ5D-5L). Findings: 55% of participants reported not feeling fully recovered. 93% reported persistent symptoms, with fatigue the most common (83%), followed by breathlessness (54%). 47% reported an increase in MRC dyspnoea scale of at least one grade. New or worse disability was reported by 24% of participants. The EQ5D-5L summary index was significantly worse following acute illness (median difference 0.1 points on a scale of 0 to 1, IQR: -0.2 to 0.0). Females under the age of 50 years were five times less likely to report feeling recovered (adjusted OR 5.09, 95% CI 1.64 to 15.74), were more likely to have greater disability (adjusted OR 4.22, 95% CI 1.12 to 15.94), twice as likely to report worse fatigue (adjusted OR 2.06, 95% CI 0.81 to 3.31) and seven times more likely to become more breathless (adjusted OR 7.15, 95% CI 2.24 to 22.83) than men of the same age. Interpretation: Survivors of Covid-19 experienced long-term symptoms, new disability, increased breathlessness, and reduced quality of life. These findings were present in young, previously healthy working age adults, and were most common in younger females. Funding: National Institute for Health Research, UK Medical Research Council, Wellcome Trust, Department for International Development and the Bill and Melinda Gates Foundation
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