On the radical cure of reducible inguinal hernia

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Why Take Both Boxes?

The crucial premise of the standard argument for two‐boxing in Newcomb's problem, a causal dominance principle, is false. We present some counterexamples. We then offer a metaethical explanation for why the counterexamples arise. Our explanation reveals a new and superior argument for two‐boxing, one that eschews the causal dominance principle in favor of a principle linking rational choice to guidance and actual value maximization

Social Learning Theory and the Influence of Male Role Models on African American Children in PROJECT 2000

This study is an assessment of observational learning commonly known as social learning theory of a group of 55 African American students who are participants in a mentoring program known as PROJECT 2000. From first through sixth grades male role models, who were largely African American, were in the classroom as teacher assistants. At the time of the study all student participants were in fifth grade. An interview was conducted featuring a short open-ended questionnaire. Students in PROJECT 2000 had an opportunity to express their feelings about the male role models that worked with them in their classroom. These interviews assisted the researcher towards understanding, how the bonding relationship between the children and the male role models in the classroom, may impact social learning

Cellular and biochemical analyses of TDP1 mediated chromosomal break repair

Tyrosyl DNA phosphodiesterase 1 (TDP1) is an end- rocessing enzyme involved in the repair of abortive topoisomerase I (Top1) complexes. Although not essential for survival, a hypomorphic mutation in TDP1 is linked to the autosomal recessive ataxia, spinocerebellar ataxia with axonal neuropathy 1 (SCAN1). SCAN1 is a rare human condition linked with neurodegeneration and ataxic gait and patients are usually wheel chair bound by their early teens. TDP1 primarily cleaves lesions at the 3’-end of DNA breaks and its most prominent substrate is stalled Top1 linked to the 3’-terminus of DNA. The enzymatic mechanism by which TDP1 functions are well understood and inhibitors are now being investigated for treatment of cancer. In contrast, the processes involved in TDP1 recruitment, localisation and regulation during the DNA damage response remain unclear. This thesis investigates how the evolutionarily driven N-terminus of TDP1, not conserved in lower Eukaryotes, is required for optimal cellular protection against genotoxic stress. I also characterise how post-translational modifications of TDP1 allow for efficient repair of transcriptionally associated, chromosomal single-strand breaks and uncover new protein interacting partners of TDP1 and their role in TDP1 mediated repair

Solvent Exfoliation of Electronic-Grade, Two-Dimensional Black Phosphorus

Solution dispersions of two-dimensional (2D) black phosphorus (BP), often referred to as phosphorene, are achieved by solvent exfoliation. These pristine, electronic-grade BP dispersions are produced with anhydrous, organic solvents in a sealed tip ultrasonication system, which circumvents BP degradation that would otherwise occur via solvated oxygen or water. Among conventional solvents, n-methyl-pyrrolidone (NMP) is found to provide stable, highly concentrated (~0.4 mg/mL) BP dispersions. Atomic force microscopy, scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy show that the structure and chemistry of solvent-exfoliated BP nanosheets are comparable to mechanically exfoliated BP flakes. Additionally, residual NMP from the liquid-phase processing suppresses the rate of BP oxidation in ambient conditions. Solvent-exfoliated BP nanosheet field-effect transistors (FETs) exhibit ambipolar behavior with current on/off ratios and mobilities up to ~10000 and ~50 cm^2/(V*s), respectively. Overall, this study shows that stable, highly concentrated, electronic-grade 2D BP dispersions can be realized by scalable solvent exfoliation, thereby presenting opportunities for large-area, high-performance BP device applications.Comment: 6 figures, 31 pages, including supporting informatio

The University of Utah\u27s Integrated Core: A case study from a commuter campus

This paper describes the Integrated Core (IC), the University of Utah’s version of integrated curricula. We begin with a rationale for the IC, providing a background on the unique student demographics, and University-wide requirements that propelled our design. Our IC focuses specifically on active living, sustainability, and social justice as target outcomes of parks, recreation, and tourism services and experiences. This rationale is followed by an outline of both the structure and implementation of the IC, including a discussion of sample assignments (incorporating both experiential learning and community engagement). Following a discussion of feedback after two years of delivering the IC, relaying benefits as well as challenges, we end with suggestions for future improvements

Endotracheal tube cuff pressure in three hospitals, and the volume required to produce an appropriate cuff pressure

BACKGROUND: Cuff pressure in endotracheal (ET) tubes should be in the range of 20–30 cm H(2)O. We tested the hypothesis that the tube cuff is inadequately inflated when manometers are not used. METHODS: With IRB approval, we studied 93 patients under general anesthesia with an ET tube in place in one teaching and two private hospitals. Anesthetists were blinded to study purpose. Cuff pressure in tube sizes 7.0 to 8.5 mm was evaluated 60 min after induction of general anesthesia using a manometer connected to the cuff pilot balloon. Nitrous oxide was disallowed. After deflating the cuff, we reinflated it in 0.5-ml increments until pressure was 20 cmH(2)O. RESULTS: Neither patient morphometrics, institution, experience of anesthesia provider, nor tube size influenced measured cuff pressure (35.3 ± 21.6 cmH(2)O). Only 27% of pressures were within 20–30 cmH(2)O; 27% exceeded 40 cmH(2)O. Although it varied considerably, the amount of air required to achieve a cuff pressure of 20 cmH(2)O was similar with each tube size. CONCLUSION: We recommend that ET cuff pressure be set and monitored with a manometer