9,593 research outputs found
Crossing Troubled Waters: Joining Non-Signatories in Maritime Arbitration - The Co-Optation and Containment of Consent in United States and British Law
Disrupting Digital Monolingualism: A report on multilingualism in digital theory and practice
This report is about the Disrupting Digital Monolingualism virtual workshop in June 2020. The DDM workshop sought to draw together a wide range of stakeholders active in confronting the current language bias in most of the digital platforms, tools, algorithms, methods, and datasets which we use in our study or practice, and to reverse the powerful impact this bias has on geocultural knowledge dynamics in the wider world. The workshop aimed to describe the state of the art across different academic disciplines and professional fields, and foster collaboration across diverse perspectives around four points of focus: Linguistic and geocultural diversity in digital knowledge infrastructures; Working with multilingual methods and data; Transcultural and translingual approaches to digital study; and Artificial intelligence, machine learning and NLP in language worlds.
Event website https://languageacts.org/digital-mediations/event/disrupting-digital-monolingualism/
This report forms part of a series of reports produced by the Digital Mediations strand of the Language Acts & Worldmaking project, in this case in collaboration with the translingual strand of the Cross-Language Dynamics project (based at the Institute of Modern Languages Research), both funded by the UK Arts and Humanities Research Council’s Open World Research Initiative. Digital Mediations explores interactions and tensions between digital culture, multilingualism and language fields including the Modern Languages
Raised serum transaminases during treatment with pegylated interferon for chronic hepatiti C
Introduction : Serum transaminases rose significantly in 7 patients with chronic hepatitis C, genotypes 2 and 3, who were treated with pegylated interferon and ribavirin.
Methods : 219 patients with chronic hepatitis C, genotypes 2 and 3, were treated between 2005 and 2011 following the same protocol. For the 7 patients presented in this paper, the initial liver screen revealed chronic hepatitis C infection only. The same liver screen was repeated following the transaminase rise during the treatment period and failed to reveal additional comorbidity.
Results : 5 male and 2 female patients with chronic hepatitis C experienced a rise in serum transaminases after commencement on treatment with pegylated interferon and ribavirin. They all achieved rapid and end of treatment virological responses. 3 of the patients achieved sustained virological response and 4 relapsed. There was no evidence to suggest that steatosis, development of autoimmunity or intercurrent illness was the cause of the liver injury. In 3 out of 7 patients, the level of transaminases exhibited a downward trend after pegylated interferon was changed to non pegylated interferon. Additionally, it is evident that in those patients whose treatment was temporarily or permanently aborted, the rise in transaminases rapidly improved and returned to baseline.
Conclusion : Our experience suggests the possibility of a toxic reaction to polyethylene glycol in a small number of patients being treated with pegylated interferon, resulting in an acute hepatitic response which resolved when therapy was stopped or switched to non-pegylated interferon
Critical Digital Pedagogies in Modern Languages – a Tutorial Collection
This introduction sets out the context for this special collection of self-learning online tutorials exploring critical pedagogies in Modern Languages. Previous research has demonstrated that, while some areas within the Modern Languages (such as language pedagogy) have a long history of engagement with digital mediation through approaches such as CALL, MALL and TELL, broader experience with digital culture and technology within the field is characterised by uncertainty, scepticism and sometimes anxiety. This is particularly apparent in the area of digital literacy acquisition – a survey we carried out in 2019 demonstrated significant interest in acquiring digital literacies appropriate to Modern Languages education and research, but also doubts about which literacies needed to be acquired and how to acquire them.
This collection consists of practical and open educational resources for use in the Modern Languages, but it also represents an interrogation of the affordances and limitations generated by digital mediation. In this introduction we highlight some of the challenges that the collection had to overcome, and in so doing, we hope to foster wider discussion about how digital learning resources can be better integrated into Modern Languages education and research across languages, across educational levels and across digital platforms
The separation of the East Australian Current: A Lagrangian approach to potential vorticity and upstream control
The East Australian Current (EAC) is the western boundary current flowing along the east coast of Australia separating from the coast at approximately 34°S. After the separation two main pathways can be distinguished, the eastward flowing Tasman Front and the extension of the EAC flowing southward. The area south of the separation latitude is eddy-rich and the separation latitude of the EAC is variable. Little is known of the properties of the water masses that separate at the bifurcation of the EAC. This paper presents new insights from the Lagrangian perspective, where the water masses that veer east and those that continue south are tracked in an eddy-permitting numerical model. The transport along the two pathways is computed, and a 1:3 ratio between transport in the EAC extension and transport in the Tasman Front is found. The results show that the "fate" of the particles is to first order already determined by the particle distribution within the EAC current upstream of the separation latitude, where 85% of the particles following the EAC extension originate from below 460 m and 90% of the particles following the Tasman Front originate from the top 460 m depth at 28°S. The separation and pathways are controlled by the structure of the isopycnals in this region. Analysis of anomalies in potential vorticity show that in the region where the two water masses overlap, the fate of the water depends on the presence of anticyclonic eddies that push isopycnals down and therefore enable particles to travel further south
Inference of Population History using Coalescent HMMs: Review and Outlook
Studying how diverse human populations are related is of historical and
anthropological interest, in addition to providing a realistic null model for
testing for signatures of natural selection or disease associations.
Furthermore, understanding the demographic histories of other species is
playing an increasingly important role in conservation genetics. A number of
statistical methods have been developed to infer population demographic
histories using whole-genome sequence data, with recent advances focusing on
allowing for more flexible modeling choices, scaling to larger data sets, and
increasing statistical power. Here we review coalescent hidden Markov models, a
powerful class of population genetic inference methods that can effectively
utilize linkage disequilibrium information. We highlight recent advances, give
advice for practitioners, point out potential pitfalls, and present possible
future research directions.Comment: 12 pages, 2 figure
Empirical modeling of the quiet time nightside magnetosphere
Empirical modeling of plasma pressure and magnetic field for the quiet time nightside magnetosphere is investigated. Two models are constructed for this study. One model, referred to here as T89R, is basically the magnetic field model of Tsyganenko (1989) but is modified by the addition of an inner eastward ring current at a radial distance of ∼3 RE as suggested by observation. The other is a combination of the T89R model and the long version of the magnetic field model of Tsyganenko (1987) such that the former dominates the magnetic field in the inner magnetosphere, whereas the latter prevails in the distant tail. The distribution of plasma pressure, which is required to balance the magnetic force for each of these two field models, is computed along the tail axis in the midnight meridian. The occurrence of pressure anisotropy in the inner magnetospheric region is also taken into account by determining an empirical fit to the observed plasma pressure anisotropy. This effort is the first attempt to obtain the plasma pressure distribution in force equilibrium with magnetic stresses from an empirical field model with the inclusion of pressure anisotropy. The inclusion of pressure anisotropy alters the plasma pressure by as much as a factor of ∼3 in the inner magnetosphere. The deduced plasma pressure profile along the tail axis is found to be in good agreement with the observed quiet time plasma pressure for geocentric distances between ∼2 and ∼35 RE
Revision of empirical electric field modeling in the inner magnetosphere using Cluster data
Using Cluster data from the Electron Drift (EDI) and the Electric Field and Wave (EFW) instruments, we revise our empirically-based, inner-magnetospheric electric field (UNH-IMEF) model at 22.662 mV/m; K-p\u3c1, 1K(p)\u3c2, 2K(p)\u3c3, 3K(p)\u3c4, 4K(p)\u3c5, and K(p)4(+). Patterns consist of one set of data and processing for smaller activities, and another for higher activities. As activity increases, the skewed potential contour related to the partial ring current appears on the nightside. With the revised analysis, we find that the skewed potential contours get clearer and potential contours get denser on the nightside and morningside. Since the fluctuating components are not negligible, standard deviations from the modeled values are included in the model. In this study, we perform validation of the derived model more extensively. We find experimentally that the skewed contours are located close to the last closed equipotential, consistent with previous theories. This gives physical context to our model and serves as one validation effort. As another validation effort, the derived results are compared with other models/measurements. From these comparisons, we conclude that our model has some clear advantages over the others
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