Chemistry and Apparent Quality of Surface Water and Ground Water Associated with Coal Basins

Personnel of the Arkansas Mining and Mineral Resources Research Institute conducted preliminary investigations on the chemistry and quality of surface and ground water associated with 12 coal-bearing sub-basins in the Arkansas Valley coal field. The coal field is approximately 60 miles long and 33 miles wide but only in 12 areas coal is thick enough and has proper quality to be termed commercial. Both surface and underground sample sites were established in each of the sub-basins with some minor variations in four areas where not all types of sites could be located. Water was collected from 19 surface points and 19 underground points in the established areas. Both field and laboratory analyses were made and elemental contents are reported herein. In the main, the chemistry and water quality suggests that all water is suitable for agricultural and industrial uses. To obtain potable water, treatment must be made to reduce calcium, magnesium, sodium sulfate and iron. The mineral content of the water is due to its contact with coal-bearing zones and, as such, reflects the mineral content of the coal. However, it is recommended that additional studies on the petrography and geochemistry of the coal, overburden and underburden is in order. Also, it is recommended that at least one detailed study be made of one of the coal sub-basins where geologic parameters can be completely established with regard to hydrogeology. This report is an important first step in determining the character and quality of Arkansas coal which must be fully understood to fully utilize this important mineral resource

Beyond Instructions to Disregard: When Objections Backfire and Interruptions Distract

Researchers have proposed many explanations for the replicated finding that jurors often fail to disregard evidence when instructed by a judge to do so. We propose a novel explanation: that the act of objecting may cause the effect because an objection (a) draws attention to the testimony and (b) heightens the perceived importance of the testimony (because of the implication that the objecting party wants to prevent jurors from using it). In previous studies, the act of objecting has always been confounded with the presence of the critical (objected-to) testimony. We devised two new experimental conditions that unconfound these factors. We found that whereas objections increase the use of objected-to (incriminating) testimony, random (non-objection) interruptions decrease use of this testimony. We conclude that, unlike random interruptions, an objection communicates to the jurors that an attorney is concerned about the objected-to testimony, increasing the perceived importance of that testimony

Dynamics of gene expression and the regulatory inference problem

From the response to external stimuli to cell division and death, the dynamics of living cells is based on the expression of specific genes at specific times. The decision when to express a gene is implemented by the binding and unbinding of transcription factor molecules to regulatory DNA. Here, we construct stochastic models of gene expression dynamics and test them on experimental time-series data of messenger-RNA concentrations. The models are used to infer biophysical parameters of gene transcription, including the statistics of transcription factor-DNA binding and the target genes controlled by a given transcription factor.Comment: revised version to appear in Europhys. Lett., new titl

Treatment of tumours with the combination of WR-2721 and cis-dichlorodiammineplatinum (II) or cyclophosphamide.

The ability of WR-2721 [S-2(3-aminopropylamino)ethyl-phosporothioic acid] to selectively protect the host against the toxic effects of multiple doses of cis-dichlorodiammineplatinum [cis-Pt] or cyclophosphamide [CY] has been studied in mice and rats bearing 3 different tumours. Selective protection against cis-Pt induced nephrotoxicity has been demonstrated under all conditions studied, with the extent of protection being inversely related to the size of the cis-Pt dose. For example, pre-treatment with 200 mg/kg of WR-2721 30 min before each weekly dose of 2 mg/kg of cis-Pt allows the administration of this cytotoxic agent for 3 times longer before nephrotoxic injury. In none of these studies was there tumour protection. The same pattern was observed with CY, but quantitation of the extent of marrow protection was not possible for the multiple treatment studies, due to the longer latent period between induced and observed death with this drug. We conclude, therefore, that for both of these drugs, selective protection of the kidney and marrow is not only maintained under conditions of multiple treatment, but actually enhanced due to the need for smaller doses of cytotoxic agents in these protocols

Skills and competences needed by nurses to allow them to deliver a safe nurse-led oral and maxillofacial oncology clinic: the Leeds experience

In Leeds, nurse-led oral and maxillofacial oncology clinics are a vital part of the care of patients who are undergoing treatment for head and neck cancer. 1 Although our service continues to evolve, it has taken a considerable amount of preparation and around six years to develop the credible, efficient, and quality service that exists today. The time it takes to implement a nurse-led clinic should not be underestimated

Early experience of a nurse-led clinic in a tertiary centre

A busy head and neck or oral and maxillofacial (OMFS) National Health Service (NHS) clinic treats patients with many different conditions. A large proportion will have cancer of the head and neck, and they will be at different stages of their treatment. Their clinical needs may be different from a larger group of patients who have been referred through the “two-week wait” referral pathway, and who are present in the same clinic for their biopsy results. We present our early experience of “fast-track” referrals and their potential effect on the overall volume of work. They are only a small number of the patients who are typically seen in a nurse-led clinic

WEATHER RELATED VARIABILITY OF CALORIMETERY PERFORMANCE IN A POORLY CONTROLLED ENVIRONMENT

Four Antech airbath calorimeters at the Hanford site were studied for three summers and two winters in a location not well-shielded from outside temperature changes. All calorimeters showed significant increases in variability of standard measurements during hot weather. The increased variability is postulated to be due to a low setting of the Peltier cold face temperature, which doesn't allow the instrument to drain heat fast enough in a hot environment. A higher setting of the Peltier cold face might lead to better performance in environments subjected to a broad range of temperatures

Progress toward curing HIV infection with hematopoietic cell transplantation.

HIV-1 infection afflicts more than 35 million people worldwide, according to 2014 estimates from the World Health Organization. For those individuals who have access to antiretroviral therapy, these drugs can effectively suppress, but not cure, HIV-1 infection. Indeed, the only documented case for an HIV/AIDS cure was a patient with HIV-1 and acute myeloid leukemia who received allogeneic hematopoietic cell transplantation (HCT) from a graft that carried the HIV-resistant CCR5-∆32/∆32 mutation. Other attempts to establish a cure for HIV/AIDS using HCT in patients with HIV-1 and malignancy have yielded mixed results, as encouraging evidence for virus eradication in a few cases has been offset by poor clinical outcomes due to the underlying cancer or other complications. Such clinical strategies have relied on HIV-resistant hematopoietic stem and progenitor cells that harbor the natural CCR5-∆32/∆32 mutation or that have been genetically modified for HIV-resistance. Nevertheless, HCT with HIV-resistant cord blood remains a promising option, particularly with inventories of CCR5-∆32/∆32 units or with genetically modified, human leukocyte antigen-matched cord blood