1,038 research outputs found
Single-Shot Electron Diffraction using a Cold Atom Electron Source
Cold atom electron sources are a promising alternative to traditional
photocathode sources for use in ultrafast electron diffraction due to greatly
reduced electron temperature at creation, and the potential for a corresponding
increase in brightness. Here we demonstrate single-shot, nanosecond electron
diffraction from monocrystalline gold using cold electron bunches generated in
a cold atom electron source. The diffraction patterns have sufficient signal to
allow registration of multiple single-shot images, generating an averaged image
with significantly higher signal-to-noise ratio than obtained with unregistered
averaging. Reflection high-energy electron diffraction (RHEED) was also
demonstrated, showing that cold atom electron sources may be useful in
resolving nanosecond dynamics of nanometre scale near-surface structures.Comment: This is an author-created, un-copyedited version of an article
published in Journal of Physics B: Atomic, Molecular and Optical Physics. IOP
Publishing Ltd is not responsible for any errors or omissions in this version
of the manuscript or any version derived from it. The Version of Record is
available online at http://dx.doi.org/10.1088/0953-4075/48/21/21400
Intergenerational Implications of Ritual in Art Education
This article introduces the concept of ritual and the role it can play in art education across generations from PK-12 schools to community collaborations. Three authors elaborate on research, personal experiences, and applications of ritual in their art education practice. The first introduces ritual within personal, historical, cultural, psychological, and sociological contexts. Then, relates these to art education curriculum and an intergenerational community collaboration. Author 2 shares experience with ritual-based artists using performance, body adornment and modification to communicate creative sacred/secular expression. Author 3 describes her hesitancy and eventual success in engaging preadolescents in ritual-based discussions. All of these perspectives hope to inspire readersâ ritual research and practice across generations
PET/MRI of Hepatic 90Y Microsphere Deposition Determines Individual Tumor Response.
PurposeThe purpose of our study is to determine if there is a relationship between dose deposition measured by PET/MRI and individual lesion response to yttrium-90 ((90)Y) microsphere radioembolization.Materials and methods26 patients undergoing lobar treatment with (90)Y microspheres underwent PET/MRI within 66 h of treatment and had follow-up imaging available. Adequate visualization of tumor was available in 24 patients, and contours were drawn on simultaneously acquired PET/MRI data. Dose volume histograms (DVHs) were extracted from dose maps, which were generated using a voxelized dose kernel. Similar contours to capture dimensional and volumetric change of tumors were drawn on follow-up imaging. Response was analyzed using both RECIST and volumetric RECIST (vRECIST) criteria.ResultsA total of 8 hepatocellular carcinoma (HCC), 4 neuroendocrine tumor (NET), 9 colorectal metastases (CRC) patients, and 3 patients with other metastatic disease met inclusion criteria. Average dose was useful in predicting response between responders and non-responders for all lesion types and for CRC lesions alone using both response criteria (p < 0.05). D70 (minimum dose to 70 % of volume) was also useful in predicting response when using vRECIST. No significant trend was seen in the other tumor types. For CRC lesions, an average dose of 29.8 Gy offered 76.9 % sensitivity and 75.9 % specificity for response.ConclusionsPET/MRI of (90)Y microsphere distribution showed significantly higher DVH values for responders than non-responders in patients with CRC. DVH analysis of (90)Y microsphere distribution following treatment may be an important predictor of response and could be used to guide future adaptive therapy trials
Management of breast cancer in an Asian man with post-traumatic stress disorder : a case report
Peer reviewedPublisher PD
Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion
The CUB and sushi multiple domains 1 (CSMD1) gene maps to chromosome 8p23, a region deleted in many cancers. Loss of CSMD1 expression is associated with poor prognosis in breast cancer suggesting that it acts as a tumour suppressor in this cancer. However, the function of CSMD1 is largely unknown. Herein, we investigated CSMD1 functions in cell line models. CSMD1 expression was suppressed in MCF10A and LNCaP cells using short hairpin RNA. Functional assays were performed focusing on the 'normal' MCF10A cell line. Suppression of CSMD1 significantly increased the proliferation, cell migration and invasiveness of MCF10A cells compared to shcontrols. shCSMD1 cells also showed significantly reduced adhesion to Matrigel and fibronectin. In a three-dimensional Matrigel model of MCF10A cells, reduced CSMD1 expression resulted in the development of larger and more poorly differentiated breast acini-like structures that displayed impaired lumen formation. Loss of CSMD1 expression disrupts a model of mammary duct formation while enhancing proliferation, migration and invasion. Our data suggest that CSMD1 is involved in the suppression of a transformed phenotype
Water Entry of a Simple Harmonic Oscillator
When a blunt body impacts an air-water interface, large hydrodynamic forces
often arise, a phenomenon many of us have unfortunately experienced in a failed
dive or "belly flop." Beyond assessing risk to biological divers, an
understanding and methods for remediation of such slamming forces are critical
to the design of numerous engineered naval and aerospace structures. Herein we
systematically investigate the role of impactor elasticity on the resultant
structural loads in perhaps the simplest possible scenario: the water entry of
a simple harmonic oscillator. Contrary to conventional intuition, we find that
"softening" the impactor does not always reduce the peak impact force, but may
also increase the force as compared to a fully rigid counterpart. Through our
combined experimental and theoretical investigation, we demonstrate that the
transition from force reduction to force amplification is delineated by a
critical "hydroelastic" factor that relates the hydrodynamic and elastic
timescales of the problem
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