Development and application of a three dimensional numerical model for predicting pollutant and sediment transport using an Eulerian-Lagrangian marker particle technique

A computer coded Lagrangian marker particle in Eulerian finite difference cell solution to the three dimensional incompressible mass transport equation, Water Advective Particle in Cell Technique, WAPIC, was developed, verified against analytic solutions, and subsequently applied in the prediction of long term transport of a suspended sediment cloud resulting from an instantaneous dredge spoil release. Numerical results from WAPIC were verified against analytic solutions to the three dimensional incompressible mass transport equation for turbulent diffusion and advection of Gaussian dye releases in unbounded uniform and uniformly sheared uni-directional flow, and for steady-uniform plug channel flow. WAPIC was utilized to simulate an analytic solution for non-equilibrium sediment dropout from an initially vertically uniform particle distribution in one dimensional turbulent channel flow

London Bridge Is Falling Down : March

https://digitalcommons.library.umaine.edu/mmb-ps/3046/thumbnail.jp

The Globe Trotters March

Globe with people walking around rim while carrying suitcases, walking dogs, and holding handshttps://scholarsjunction.msstate.edu/cht-sheet-music/11446/thumbnail.jp

The Star Of The Night : Reverie

https://digitalcommons.library.umaine.edu/mmb-ps/1207/thumbnail.jp

Field Flowers : Waltz

https://digitalcommons.library.umaine.edu/mmb-ps/3013/thumbnail.jp

Love\u27s Consolation : A Meditation for Piano or Organ

https://digitalcommons.library.umaine.edu/mmb-ps/1196/thumbnail.jp

Towards a Unified Disease Mechanism for tRNA Synthetase-Mediated Peripheral Neuropathy

Charcot-Marie-Tooth disease (CMT) is a debilitating inherited peripheral neuropathy resulting in progressive distal muscle atrophy and loss of sensation. CMT is genetically heterogeneous, with mutations in over 80 different genes leading to demyelinating or axonal forms. There are genetically similar subgroups, including the largest protein family implicated in the disease, the tRNA synthetases (ARSs). ARSs are responsible for aminoacylation of tRNAs during translation and are therefore ubiquitously expressed and essential proteins. Dominant mutations in at least five ARSs cause axonal forms of CMT. How mutations in ARSs cause CMT is unclear, however, the similar clinical presentation of patients suggests shared disease mechanisms. To investigate peripheral axon sensitivity to dominant mutations in ARSs, we first performed an extensive examination of motor axon terminals in two mouse models of CMT type 2D, caused by mutations in glycyl-ARS (GARS). Our findings reveal a progressive, presynaptic dysfunction at the mutant neuromuscular junction that correlates with fewer acetylcholine vesicles, release sites, and mitochondria. One of the proposed disease mechanisms of mutant ARSs is through gain-of-function impaiments in translation. Because all ARSs participate in translation, impairment in this process is an attractive disease mechanism to test in mammalian models of ARS-associated CMT. To this end we have profiled translation and transcription in motor neurons of three CMT2D mouse models. This profiling has revealed global impairments in translation in mutant Gars motor neurons. Identification of the integrated stress response (ISR) only in the largest motor and sensory peripheral neurons has further refined our understanding of the cell type-specificity of CMT2D. Activation of the ISR occurs in these cells through the translational homeostasis-sensing kinase, GCN2, indicating that GCN2 is responding to impairments in translation. Genetic removal of GCN2 alleviates mutant Gars neuropathy, suggesting that chronic activation of the ISR contributes to CMT2D. The ISR is also activated in motor neurons of mice with dominant mutations in Yars, a model of CMT type C. These data support impairments in translation as a disease mechanism in mice with dominant mutations in Gars and Yars and have increased our understanding of the cellular and molecular pathways leading to motor axon degeneration

The screwworm eradication data system archives

The archives accumulated during 1 year of operation of the Satellite Temperature-Monitoring System during development of the Screwworm Eradication Data System are reported. Brief descriptions of all the kinds of tapes, as well as their potential uses, are presented. Reference is made to other documents that explain the generation of these data

Affect and Inference in Bayesian Knowledge Tracing with a Robot Tutor

In this paper, we present work to construct a robotic tutoring system that can assess student knowledge in real time during an educational interaction. Like a good human teacher, the robot draws on multimodal data sources to infer whether students have mastered language skills. Specifically, the model extends the standard Bayesian Knowledge Tracing algorithm to incorporate an estimate of the student's affective state (whether he/she is confused, bored, engaged, smiling, etc.) in order to predict future educational performance. We propose research to answer two questions: First, does augmenting the model with affective information improve the computational quality of inference? Second, do humans display more prominent affective signals in an interaction with a robot, compared to a screen-based agent? By answering these questions, this work has the potential to provide both algorithmic and human-centered motivations for further development of robotic systems that tightly integrate affect understanding and complex models of inference with interactive, educational robots.National Science Foundation (U.S.) (Grant CCF-1138986)National Science Foundation (U.S.). Graduate Research Fellowship Program (Grant No. 1122374

Veterinary Hygiene

The late Charles Henry Stange. said, During the past fifteen years, the prevention and control of the infectious diseases of animals has become a state and national problem, the work being organized on the basis of state and national cooperation. Livestock owners have available to them much information concerning animal diseases and the public is becoming increasingly conscious of the possibilities of disease transmission from animals to man. At present, there is little information available in the epidemiology of the contagious diseases of animals which would make their successful control and eradication very much easier. In the midst of the transition period in which we now find ourselves, it is apparent that veterinarians need considerable information, much of which may seem of a diverse nature, but all having a significant bearing on the most important problem confronting the veterinary profession today viz., disease prevention and control