24 research outputs found

    The Protestant Ethic Thesis: An Internal Critque

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    Max Weber's thesis of a relation between a Protestant ethic and a spirit of capitalism is examined. The Calvinist calling is taken as the central notion of Weber's thesis. Weber fails to demonstrate that the doctrine of the calling would channel the motivational force of religious interests into ascetic, economic activity that could be innovative in the face of traditional patterns ofbehavior. He fails in two ways: (1) he does not demonstrate a strict logical, meaningful relation between these elements; and (2) he does not account for the changing historical dynamics of Calvinism itself. If the configuration of events occurred as Weber argued, then nonreligious factors would be crucial in bringing it about. Yet, such factors take us outside of the framework in which Weber was working and, more seriously, they contest the very basis of his argument: the influence ofreligious forces on the capitalistic spirit

    Aging and the negative geotaxis response (NGR) of adult Drosophila.

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    <p>The NGR of outcrossed wild-type control male and female flies (<i>w<sup>1118</sup>/+</i>) was used to determining changes in average climbing index (CI, distance traveled within 5 seconds) between the ages of 1 and 4-weeks. *** P ≤ 0.001. See <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0132768#pone.0132768.s001" target="_blank">S1 Fig</a></b> for the design of the NGR apparatus and additional details.</p

    Aging and Autophagic Function Influences the Progressive Decline of Adult Drosophila Behaviors

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    <div><p>Multiple neurological disorders are characterized by the abnormal accumulation of protein aggregates and the progressive impairment of complex behaviors. Our Drosophila studies demonstrate that middle-aged wild-type flies (WT, ~4-weeks) exhibit a marked accumulation of neural aggregates that is commensurate with the decline of the autophagy pathway. However, enhancing autophagy via neuronal over-expression of <i>Atg8a</i> (Atg8a-OE) reduces the age-dependent accumulation of aggregates. Here we assess basal locomotor activity profiles for single- and group-housed male and female WT flies and observed that only modest behavioral changes occurred by 4-weeks of age, with the noted exception of group-housed male flies. Male flies in same-sex social groups exhibit a progressive increase in nighttime activity. Infrared videos show aged group-housed males (4-weeks) are engaged in extensive bouts of courtship during periods of darkness, which is partly repressed during lighted conditions. Together, these nighttime courtship behaviors were nearly absent in young WT flies and aged Atg8a-OE flies. Previous studies have indicated a regulatory role for olfaction in male courtship partner choice. Coincidently, the mRNA expression profiles of several olfactory genes decline with age in WT flies; however, they are maintained in age-matched Atg8a-OE flies. Together, these results suggest that middle-aged male flies develop impairments in olfaction, which could contribute to the dysregulation of courtship behaviors during dark time periods. Combined, our results demonstrate that as Drosophila age, they develop early behavior defects that are coordinate with protein aggregate accumulation in the nervous system. In addition, the nighttime activity behavior is preserved when neuronal autophagy is maintained (Atg8a-OE flies). Thus, environmental or genetic factors that modify autophagic capacity could have a positive impact on neuronal aging and complex behaviors.</p></div

    Progressive accumulation of neural aggregates in normal aged Drosophila.

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    <p>Sequential protein extracts were prepared from adult male fly heads at different ages (1-day to 4-weeks) and used for Western blot analyses of Ref(2)P and ubiquitinated proteins. The Triton-X Fraction contains the Triton X-100 soluble proteins, while the SDS Fraction identifies the Triton X-100 insoluble/SDS-soluble proteins that have taken on aggregate-like characteristics.</p
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