75 research outputs found
cluster structure in B
The cluster structures of the excited states in B are studied by
analyzing the isoscalar monopole and quadrupole strengths in the
B(,) reaction at MeV. The excitation strengths are
compared with the predictions by the shell-model and antisymmetrized
molecular-dynamics (AMD) calculations. It is found that the large monopole
strength for the state at MeV is well described by the AMD
calculation and is an evidence for a developed cluster structure.Comment: Revised according to the referees' comment
Effect of Cryogrinding on Chemical Stability of the Sparingly Water-Soluble Drug Furosemide
Purpose To investigate the effect of cryogrinding on chemical
stability of the diuretic agent furosemide and its mixtures with
selected excipients.
Methods Furosemide was ground at liquid nitrogen temperature
for 30, 60, 120 and 180 min. Mixtures of furosemide-PVP
and furosemide-inulin (1:1) were milled under cryogenic conditions.
Materials were analyzed by XRD, UPLC, MS and NMR.
Results Upon increasing the milling time, a significant build-up
of an unidentified impurity 1, probably the main degradation
product, was noticed. Cogrinding of furosemide with PVP and
inulin worsened chemical stabilization of the pharmaceutical.
The main degradation product formed upon cryomilling was
subsequently identified as 4-chloro-5-sulfamoylanthranilic acid
(CSA). Based on some theoretical considerations involving
specific milling conditions, the milling intensity and an expected
specific milling dose have been calculated. Results indicate that
cryogenic grinding is capable to initiate mechanically induced
decomposition of furosemide.Conclusions Cryogenic grinding can activate and accelerate
not only structural changes (solid state amorphization) but also
chemical decomposition of pharmaceuticals. A cryogenic
milling device should be considered as a chemical reactor,
where under favourable conditions chemical reactions could be
mechanically initiated
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Volume: 48Start Page: 240End Page: 24
Knowledge of final-year medical students at the University of the Free State of hand hygiene as a basic infection control measure
Background: One of the main reasons for the spread of infection in the healthcare environment is inadequate hand hygiene. Poor knowledge of hand hygiene techniques leads to poor compliance. This study aimed to determine Free State University finalyear medical students’ knowledge of hand hygiene as a basic infection control measure. Methods: This was a cross-sectional study using self-administered anonymous questionnaires. The questions and memorandum were based on an extensive literature review with WHO documentation on the guidelines for hand hygiene in health care. Each participant received an envelope with an optical computer card, questionnaire and information document during a pre-arranged class. Participants recorded their answers on the card by shading in the squares corresponding to their responses.Results: The average score of the 107 participants was 46.8% (range 10.1–73.6%). Participants who felt that they had basic knowledge of hand hygiene (n = 32, 30.5%) had an average score of 47.9%. Participants with a self-reported knowledge level of more than basic but less than advanced (n = 56, 53.3%) had an average score of 44.9% while those who reported advanced knowledge (n = 17, 16.2%) had an average score of 50.8%. Three-quarters (n = 81, 77.1%) felt that their training was sufficient. Only 53.3% knew that the most important way to prevent the spread of infection is good hand hygiene. Only 10.5% of the students knew that hands should not be rinsed with water after using alcohol-based sanitisers.Conclusion: Medical students have a poor level of knowledge regarding hand hygiene as a basic measure of infection control
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